Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143720746> ?p ?o ?g. }
- W2143720746 endingPage "2813" @default.
- W2143720746 startingPage "2805" @default.
- W2143720746 abstract "Abstract Although several groups have investigated the role of SHIP in macrophage (Mϕ) development and function, SHIP’s contribution to the generation, maturation, and innate immune activation of dendritic cells (DCs) is poorly understood. We show herein that SHIP negatively regulates the generation of DCs from bone marrow precursors in vitro and in vivo, as illustrated by the enhanced expansion of DCs from SHIP−/− GM-CSF cultures, as well as increased numbers of DCs in the spleens of SHIP-deficient mice. Interestingly, however, these SHIP−/− DCs display a relatively immature phenotype and secrete substantially lower levels of IL-12 after TLR ligand stimulation than wild type DCs. This, in turn, leads to a dramatically reduced stimulation of Ag-specific T cell proliferation and Th1 cell responses in vitro and in vivo. This immature phenotype of SHIP−/− DCs could be reversed with the PI3K inhibitors LY294002 and wortmannin, suggesting that SHIP promotes DC maturation by reducing the levels of the PI3K second messenger phosphatidylinositol-3,4,5-trisphosphate. These results are consistent with SHIP being a negative regulator of GM-CSF–derived DC generation but a positive regulator of GM-CSF–derived DC maturation and function." @default.
- W2143720746 created "2016-06-24" @default.
- W2143720746 creator A5004129459 @default.
- W2143720746 creator A5017180599 @default.
- W2143720746 creator A5025412358 @default.
- W2143720746 creator A5034788128 @default.
- W2143720746 creator A5041280601 @default.
- W2143720746 creator A5079926315 @default.
- W2143720746 creator A5090967006 @default.
- W2143720746 date "2010-03-15" @default.
- W2143720746 modified "2023-10-01" @default.
- W2143720746 title "SHIP Is Required for Dendritic Cell Maturation" @default.
- W2143720746 cites W124239641 @default.
- W2143720746 cites W1557103043 @default.
- W2143720746 cites W1560991329 @default.
- W2143720746 cites W1590680361 @default.
- W2143720746 cites W1606072873 @default.
- W2143720746 cites W1831625328 @default.
- W2143720746 cites W1871385741 @default.
- W2143720746 cites W1967945803 @default.
- W2143720746 cites W1972758309 @default.
- W2143720746 cites W1980547319 @default.
- W2143720746 cites W1984683131 @default.
- W2143720746 cites W1985898120 @default.
- W2143720746 cites W1986058380 @default.
- W2143720746 cites W1995744610 @default.
- W2143720746 cites W2010419832 @default.
- W2143720746 cites W2026145775 @default.
- W2143720746 cites W2034988351 @default.
- W2143720746 cites W2037678644 @default.
- W2143720746 cites W2039358381 @default.
- W2143720746 cites W2042629891 @default.
- W2143720746 cites W2046783872 @default.
- W2143720746 cites W2051118426 @default.
- W2143720746 cites W2051141212 @default.
- W2143720746 cites W2051731494 @default.
- W2143720746 cites W2052721892 @default.
- W2143720746 cites W2054004157 @default.
- W2143720746 cites W2060671799 @default.
- W2143720746 cites W2069089745 @default.
- W2143720746 cites W2075078512 @default.
- W2143720746 cites W2075256814 @default.
- W2143720746 cites W2080503511 @default.
- W2143720746 cites W2082263327 @default.
- W2143720746 cites W2089937309 @default.
- W2143720746 cites W2090640877 @default.
- W2143720746 cites W2107425729 @default.
- W2143720746 cites W2111220263 @default.
- W2143720746 cites W2112251628 @default.
- W2143720746 cites W2126397566 @default.
- W2143720746 cites W2140430241 @default.
- W2143720746 cites W2148044949 @default.
- W2143720746 cites W2150927114 @default.
- W2143720746 cites W2151313755 @default.
- W2143720746 cites W2159886660 @default.
- W2143720746 cites W2161152489 @default.
- W2143720746 cites W2162332365 @default.
- W2143720746 cites W2164139183 @default.
- W2143720746 cites W2170966854 @default.
- W2143720746 doi "https://doi.org/10.4049/jimmunol.0903170" @default.
- W2143720746 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20154203" @default.
- W2143720746 hasPublicationYear "2010" @default.
- W2143720746 type Work @default.
- W2143720746 sameAs 2143720746 @default.
- W2143720746 citedByCount "39" @default.
- W2143720746 countsByYear W21437207462012 @default.
- W2143720746 countsByYear W21437207462013 @default.
- W2143720746 countsByYear W21437207462014 @default.
- W2143720746 countsByYear W21437207462015 @default.
- W2143720746 countsByYear W21437207462016 @default.
- W2143720746 countsByYear W21437207462017 @default.
- W2143720746 countsByYear W21437207462018 @default.
- W2143720746 countsByYear W21437207462020 @default.
- W2143720746 countsByYear W21437207462021 @default.
- W2143720746 countsByYear W21437207462022 @default.
- W2143720746 crossrefType "journal-article" @default.
- W2143720746 hasAuthorship W2143720746A5004129459 @default.
- W2143720746 hasAuthorship W2143720746A5017180599 @default.
- W2143720746 hasAuthorship W2143720746A5025412358 @default.
- W2143720746 hasAuthorship W2143720746A5034788128 @default.
- W2143720746 hasAuthorship W2143720746A5041280601 @default.
- W2143720746 hasAuthorship W2143720746A5079926315 @default.
- W2143720746 hasAuthorship W2143720746A5090967006 @default.
- W2143720746 hasBestOaLocation W21437207461 @default.
- W2143720746 hasConcept C104317684 @default.
- W2143720746 hasConcept C134018914 @default.
- W2143720746 hasConcept C150903083 @default.
- W2143720746 hasConcept C203014093 @default.
- W2143720746 hasConcept C207001950 @default.
- W2143720746 hasConcept C24998067 @default.
- W2143720746 hasConcept C2778170410 @default.
- W2143720746 hasConcept C2778308172 @default.
- W2143720746 hasConcept C55493867 @default.
- W2143720746 hasConcept C62478195 @default.
- W2143720746 hasConcept C6929976 @default.
- W2143720746 hasConcept C86554907 @default.
- W2143720746 hasConcept C86803240 @default.
- W2143720746 hasConcept C8891405 @default.