Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143744733> ?p ?o ?g. }
- W2143744733 endingPage "5161" @default.
- W2143744733 startingPage "5150" @default.
- W2143744733 abstract "Based on studies of sheep, ileal Peyer's patches (IPP) have been regarded as a type of primary lymphoid tissue similar to the bursa of Fabricius in chicken. Because bursectomy results in B cell deficiency, we wondered whether resection of the IPP of piglets would have a similar effect. Comparison of IPP-resected, surgical shams and untreated germ-free piglets, all of which were later colonized with a defined commensal flora, demonstrated that resection of the IPP did not alter the level and phenotype of B and T cells in lymphoid tissues and the blood 10 wk after surgery. Additionally, colonization of IPP caused a shift from the fetal type of lymphocyte distribution to the adult type that is characterized by prevalence of B cells, with many of them representing IgA(+) switched B cells or displaying a more mature CD2(-)CD21(+) and CD2(-)CD21(-) phenotype. Moreover, colonization leads to appearance of effector CD4(+)CD8(+) αβ T helper and CD2(+)CD8(-) γδ T cells. Comparison of germ-free with colonized pigs and experiments utilizing surgical transposition of jejunal Peyer's patch into terminal ileum or construction of isolated ileal loops indicated that lymphocyte development in IPP is dependent on colonization. Although our studies confirmed higher mitotic and apoptotic rates in IPP, they failed to identify any cell populations that resemble developing B lineage cells in the bone marrow. These results indicate that porcine IPP are not required for systemic B cell generation or maintenance, but they are secondary lymphoid tissue that appears important in immune responses to colonizing bacteria." @default.
- W2143744733 created "2016-06-24" @default.
- W2143744733 creator A5004484104 @default.
- W2143744733 creator A5022337460 @default.
- W2143744733 creator A5025520471 @default.
- W2143744733 creator A5027273015 @default.
- W2143744733 creator A5049242615 @default.
- W2143744733 creator A5049807663 @default.
- W2143744733 creator A5069985236 @default.
- W2143744733 creator A5073359386 @default.
- W2143744733 date "2011-10-17" @default.
- W2143744733 modified "2023-10-13" @default.
- W2143744733 title "Ileal Peyer’s Patches Are Not Necessary for Systemic B Cell Development and Maintenance and Do Not Contribute Significantly to the Overall B Cell Pool in Swine" @default.
- W2143744733 cites W1504136545 @default.
- W2143744733 cites W1531803131 @default.
- W2143744733 cites W1574153591 @default.
- W2143744733 cites W1601559584 @default.
- W2143744733 cites W1605244573 @default.
- W2143744733 cites W1648713449 @default.
- W2143744733 cites W1676995254 @default.
- W2143744733 cites W1967255685 @default.
- W2143744733 cites W1974202095 @default.
- W2143744733 cites W1975344153 @default.
- W2143744733 cites W1986945574 @default.
- W2143744733 cites W1998382801 @default.
- W2143744733 cites W1998635307 @default.
- W2143744733 cites W1999627881 @default.
- W2143744733 cites W1999885426 @default.
- W2143744733 cites W2001760797 @default.
- W2143744733 cites W2010755343 @default.
- W2143744733 cites W2013734898 @default.
- W2143744733 cites W2017533703 @default.
- W2143744733 cites W2018732756 @default.
- W2143744733 cites W2021225863 @default.
- W2143744733 cites W2023315327 @default.
- W2143744733 cites W2025805828 @default.
- W2143744733 cites W2035965693 @default.
- W2143744733 cites W2036287577 @default.
- W2143744733 cites W2040058005 @default.
- W2143744733 cites W2043819541 @default.
- W2143744733 cites W2046699444 @default.
- W2143744733 cites W2047539257 @default.
- W2143744733 cites W2049910116 @default.
- W2143744733 cites W2052182226 @default.
- W2143744733 cites W2052452765 @default.
- W2143744733 cites W2053569911 @default.
- W2143744733 cites W2056558184 @default.
- W2143744733 cites W2056954651 @default.
- W2143744733 cites W2057065295 @default.
- W2143744733 cites W2057902325 @default.
- W2143744733 cites W2063512883 @default.
- W2143744733 cites W2071082533 @default.
- W2143744733 cites W2071475899 @default.
- W2143744733 cites W2080444258 @default.
- W2143744733 cites W2095384546 @default.
- W2143744733 cites W2107679818 @default.
- W2143744733 cites W2110696892 @default.
- W2143744733 cites W2113949567 @default.
- W2143744733 cites W2125844057 @default.
- W2143744733 cites W2140917057 @default.
- W2143744733 cites W2145407859 @default.
- W2143744733 cites W2161285087 @default.
- W2143744733 doi "https://doi.org/10.4049/jimmunol.1101879" @default.
- W2143744733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22013120" @default.
- W2143744733 hasPublicationYear "2011" @default.
- W2143744733 type Work @default.
- W2143744733 sameAs 2143744733 @default.
- W2143744733 citedByCount "50" @default.
- W2143744733 countsByYear W21437447332012 @default.
- W2143744733 countsByYear W21437447332013 @default.
- W2143744733 countsByYear W21437447332014 @default.
- W2143744733 countsByYear W21437447332015 @default.
- W2143744733 countsByYear W21437447332016 @default.
- W2143744733 countsByYear W21437447332017 @default.
- W2143744733 countsByYear W21437447332018 @default.
- W2143744733 countsByYear W21437447332019 @default.
- W2143744733 countsByYear W21437447332020 @default.
- W2143744733 countsByYear W21437447332021 @default.
- W2143744733 countsByYear W21437447332022 @default.
- W2143744733 countsByYear W21437447332023 @default.
- W2143744733 crossrefType "journal-article" @default.
- W2143744733 hasAuthorship W2143744733A5004484104 @default.
- W2143744733 hasAuthorship W2143744733A5022337460 @default.
- W2143744733 hasAuthorship W2143744733A5025520471 @default.
- W2143744733 hasAuthorship W2143744733A5027273015 @default.
- W2143744733 hasAuthorship W2143744733A5049242615 @default.
- W2143744733 hasAuthorship W2143744733A5049807663 @default.
- W2143744733 hasAuthorship W2143744733A5069985236 @default.
- W2143744733 hasAuthorship W2143744733A5073359386 @default.
- W2143744733 hasBestOaLocation W21437447331 @default.
- W2143744733 hasConcept C134018914 @default.
- W2143744733 hasConcept C159654299 @default.
- W2143744733 hasConcept C167672396 @default.
- W2143744733 hasConcept C181152851 @default.
- W2143744733 hasConcept C196978929 @default.
- W2143744733 hasConcept C203014093 @default.
- W2143744733 hasConcept C2777226302 @default.
- W2143744733 hasConcept C2777761686 @default.