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• W2143746096 abstract "There is by no means a clear-cut pattern of mutations contributing to gastric cancers, and gastric cancer research can be hampered by the diversity of factors that can induce gastric cancer, such as Helicobacter pylori infection, diet, ageing and other environmental factors. Tumours are unquestionably riddled with genetic changes yet we are faced with an unsolvable puzzle with respect to a temporal relationship. It is postulated that inherited genetic factors may be more important in early-onset gastric cancer (EOGC) than in gastric cancers found in older patients as they have less exposure to environmental carcinogens. EOGC, therefore, could provide a key to unravelling the genetic changes in gastric carcinogenesis. Gastric cancers occurring in young patients provide an ideal background on which to try and uncover the initiating stages of gastric carcinogenesis. This review summarizes the literature regarding EOGC and also presents evidence that these cancers have a unique molecular-genetic phenotype, distinct from conventional gastric cancer." @default.
• W2143746096 created "2016-06-24" @default.
• W2143746096 creator A5063002715 @default.
• W2143746096 creator A5072234764 @default.
• W2143746096 date "2010-01-01" @default.
• W2143746096 modified "2023-10-09" @default.
• W2143746096 title "Early-onset gastric cancer: Learning lessons from the young" @default.
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• W2143746096 doi "https://doi.org/10.4251/wjgo.v2.i2.59" @default.
• W2143746096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2998932" @default.
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