Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143755862> ?p ?o ?g. }
- W2143755862 endingPage "3314" @default.
- W2143755862 startingPage "3305" @default.
- W2143755862 abstract "Abstract Acute and chronic graft-versus-host disease (GVHD) remain the major complications limiting the efficacy of allogeneic hemopoietic stem cell transplantation. Chronic GVHD can evolve from acute GVHD, or in some cases may overlap with acute GVHD, but how acute GVHD evolves to chronic GVHD is unknown. In this study, in a classical CD8+ T cell-dependent mouse model, we found that pathogenic donor CD4+ T cells developed from engrafted hemopoietic stem cells (HSCs) in C57BL/6SJL(B6/SJL, H-2b) mice suffering from acute GVHD after receiving donor CD8+ T cells and HSCs from C3H.SW mice (H-2b). These CD4+ T cells were activated, infiltrated into GVHD target tissues, and produced high levels of IFN-γ. These in vivo-generated CD4+ T cells caused lesions characteristic of chronic GVHD when adoptively transferred into secondary allogeneic recipients and also caused GVHD when administered into autologous C3H.SW recipients. The in vivo generation of pathogenic CD4+ T cells from engrafted donor HSCs was thymopoiesis dependent. Keratinocyte growth factor treatment improved the reconstitution of recipient thymic dendritic cells in CD8+ T cell-repleted allogeneic hemopoietic stem cell transplantation and prevented the development of pathogenic donor CD4+ T cells. These results suggest that de novo-generated donor CD4+ T cells, arising during acute graft-versus-host reactions, are key contributors to the evolution from acute to chronic GVHD. Preventing or limiting thymic damage may directly ameliorate chronic GVHD." @default.
- W2143755862 created "2016-06-24" @default.
- W2143755862 creator A5001556956 @default.
- W2143755862 creator A5030528219 @default.
- W2143755862 creator A5042225479 @default.
- W2143755862 creator A5091612581 @default.
- W2143755862 date "2007-09-01" @default.
- W2143755862 modified "2023-10-04" @default.
- W2143755862 title "CD4+ T Cells Generated De Novo from Donor Hemopoietic Stem Cells Mediate the Evolution from Acute to Chronic Graft-versus-Host Disease" @default.
- W2143755862 cites W1490032473 @default.
- W2143755862 cites W1511607328 @default.
- W2143755862 cites W1535594612 @default.
- W2143755862 cites W1537503588 @default.
- W2143755862 cites W1544331058 @default.
- W2143755862 cites W1666992241 @default.
- W2143755862 cites W1930627543 @default.
- W2143755862 cites W1944382470 @default.
- W2143755862 cites W1963674865 @default.
- W2143755862 cites W1964687178 @default.
- W2143755862 cites W1971103070 @default.
- W2143755862 cites W1976460197 @default.
- W2143755862 cites W1980927128 @default.
- W2143755862 cites W1984893754 @default.
- W2143755862 cites W1985513262 @default.
- W2143755862 cites W1988200269 @default.
- W2143755862 cites W1991504720 @default.
- W2143755862 cites W2001457611 @default.
- W2143755862 cites W2002690240 @default.
- W2143755862 cites W2002910367 @default.
- W2143755862 cites W2018718597 @default.
- W2143755862 cites W2020169030 @default.
- W2143755862 cites W2030761613 @default.
- W2143755862 cites W2031139135 @default.
- W2143755862 cites W2036872637 @default.
- W2143755862 cites W2040547822 @default.
- W2143755862 cites W2041434453 @default.
- W2143755862 cites W2041438140 @default.
- W2143755862 cites W2042961427 @default.
- W2143755862 cites W2043966655 @default.
- W2143755862 cites W2054405406 @default.
- W2143755862 cites W2068765603 @default.
- W2143755862 cites W2073292917 @default.
- W2143755862 cites W2073474757 @default.
- W2143755862 cites W2074717114 @default.
- W2143755862 cites W2076937813 @default.
- W2143755862 cites W2077453377 @default.
- W2143755862 cites W2078016443 @default.
- W2143755862 cites W2080716137 @default.
- W2143755862 cites W2081703273 @default.
- W2143755862 cites W2087363277 @default.
- W2143755862 cites W2090810530 @default.
- W2143755862 cites W2091886117 @default.
- W2143755862 cites W2094173132 @default.
- W2143755862 cites W2098159645 @default.
- W2143755862 cites W2105604650 @default.
- W2143755862 cites W2110881834 @default.
- W2143755862 cites W2113919882 @default.
- W2143755862 cites W2114521050 @default.
- W2143755862 cites W2118063672 @default.
- W2143755862 cites W2122722718 @default.
- W2143755862 cites W2134781215 @default.
- W2143755862 cites W2137007247 @default.
- W2143755862 cites W2144897379 @default.
- W2143755862 cites W2146821812 @default.
- W2143755862 cites W2152345008 @default.
- W2143755862 cites W2163733482 @default.
- W2143755862 cites W2411848158 @default.
- W2143755862 cites W4235525435 @default.
- W2143755862 cites W4238511341 @default.
- W2143755862 cites W4239112493 @default.
- W2143755862 cites W4256235973 @default.
- W2143755862 cites W70404253 @default.
- W2143755862 doi "https://doi.org/10.4049/jimmunol.179.5.3305" @default.
- W2143755862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17709547" @default.
- W2143755862 hasPublicationYear "2007" @default.
- W2143755862 type Work @default.
- W2143755862 sameAs 2143755862 @default.
- W2143755862 citedByCount "77" @default.
- W2143755862 countsByYear W21437558622012 @default.
- W2143755862 countsByYear W21437558622013 @default.
- W2143755862 countsByYear W21437558622014 @default.
- W2143755862 countsByYear W21437558622015 @default.
- W2143755862 countsByYear W21437558622016 @default.
- W2143755862 countsByYear W21437558622017 @default.
- W2143755862 countsByYear W21437558622018 @default.
- W2143755862 countsByYear W21437558622019 @default.
- W2143755862 countsByYear W21437558622020 @default.
- W2143755862 countsByYear W21437558622021 @default.
- W2143755862 countsByYear W21437558622022 @default.
- W2143755862 countsByYear W21437558622023 @default.
- W2143755862 crossrefType "journal-article" @default.
- W2143755862 hasAuthorship W2143755862A5001556956 @default.
- W2143755862 hasAuthorship W2143755862A5030528219 @default.
- W2143755862 hasAuthorship W2143755862A5042225479 @default.
- W2143755862 hasAuthorship W2143755862A5091612581 @default.
- W2143755862 hasBestOaLocation W21437558621 @default.
- W2143755862 hasConcept C109159458 @default.
- W2143755862 hasConcept C126322002 @default.