FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143758758> ?p ?o ?g. }

• W2143758758 endingPage "110" @default.
• W2143758758 startingPage "103" @default.
• W2143758758 abstract "Urinary tract infections (UTIs) cause end-stage renal disease (ESRD) but the molecular mechanisms have remained unclear. Recently, the interleukin (IL)-8 receptor was shown to control disease susceptibility in mice and low IL-8 receptor expression was observed in pyelonephritis-prone patients.Intravesical Escherichia coli infection was established in mIL-8Rh-/- or Balb/c control mice. Survival, bacterial persistence, and histology were used as measurements of disease severity.Within 2 days, 19/30 mIL-8Rh-/- mice developed lethal infection with bacteremia. Surviving mice remained infected and developed progressive renal damage with pathologic neutrophil accumulation and abscess formation first under the pelvic epithelium and then throughout the tissue. Recruited immune effector cells were unable to remove the dying neutrophils and frustrated macrophages formed foam cell aggregates. As a result, there was successive destruction of the mucosal barrier, medulla and cortex and necrosis of the renal papilla. The mIL-8Rh+/+ mice all survived and infection was cleared within a few days without symptoms or tissue pathology.mIL-8Rh-/- mice develop acute bacteremic pyelonephritis and renal scarring due to a dysfunctional neutrophil response. The tissue damage resembles human disease, and these mice offer a model system to study the molecular mechanisms of renal scarring." @default.
• W2143758758 created "2016-06-24" @default.
• W2143758758 creator A5006413469 @default.
• W2143758758 creator A5025353214 @default.
• W2143758758 creator A5056152719 @default.
• W2143758758 creator A5062746910 @default.
• W2143758758 creator A5075750865 @default.
• W2143758758 creator A5076553442 @default.
• W2143758758 date "2005-01-01" @default.
• W2143758758 modified "2023-10-13" @default.
• W2143758758 title "Natural history of renal scarring in susceptible mIL-8Rh-/- mice" @default.
• W2143758758 cites W1776935265 @default.
• W2143758758 cites W1936763432 @default.
• W2143758758 cites W1958230690 @default.
• W2143758758 cites W1992057102 @default.
• W2143758758 cites W1994845843 @default.
• W2143758758 cites W1999823179 @default.
• W2143758758 cites W2005365259 @default.
• W2143758758 cites W2006619880 @default.
• W2143758758 cites W2010745090 @default.
• W2143758758 cites W2014897406 @default.
• W2143758758 cites W2021443768 @default.
• W2143758758 cites W2025968135 @default.
• W2143758758 cites W2040037959 @default.
• W2143758758 cites W2040268763 @default.
• W2143758758 cites W2059526871 @default.
• W2143758758 cites W2066770452 @default.
• W2143758758 cites W2076482357 @default.
• W2143758758 cites W2083099843 @default.
• W2143758758 cites W2086281512 @default.
• W2143758758 cites W2087044185 @default.
• W2143758758 cites W2099877214 @default.
• W2143758758 cites W2115536580 @default.
• W2143758758 cites W2134125629 @default.
• W2143758758 cites W2141770040 @default.
• W2143758758 cites W2144498842 @default.
• W2143758758 cites W2147594065 @default.
• W2143758758 cites W2150412000 @default.
• W2143758758 doi "https://doi.org/10.1111/j.1523-1755.2005.00060.x" @default.
• W2143758758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15610233" @default.
• W2143758758 hasPublicationYear "2005" @default.
• W2143758758 type Work @default.
• W2143758758 sameAs 2143758758 @default.
• W2143758758 citedByCount "37" @default.
• W2143758758 countsByYear W21437587582012 @default.
• W2143758758 countsByYear W21437587582014 @default.
• W2143758758 countsByYear W21437587582015 @default.
• W2143758758 countsByYear W21437587582016 @default.
• W2143758758 countsByYear W21437587582017 @default.
• W2143758758 countsByYear W21437587582020 @default.
• W2143758758 countsByYear W21437587582021 @default.
• W2143758758 countsByYear W21437587582022 @default.
• W2143758758 crossrefType "journal-article" @default.
• W2143758758 hasAuthorship W2143758758A5006413469 @default.
• W2143758758 hasAuthorship W2143758758A5025353214 @default.
• W2143758758 hasAuthorship W2143758758A5056152719 @default.
• W2143758758 hasAuthorship W2143758758A5062746910 @default.
• W2143758758 hasAuthorship W2143758758A5075750865 @default.
• W2143758758 hasAuthorship W2143758758A5076553442 @default.
• W2143758758 hasBestOaLocation W21437587581 @default.
• W2143758758 hasConcept C126322002 @default.
• W2143758758 hasConcept C142724271 @default.
• W2143758758 hasConcept C203014093 @default.
• W2143758758 hasConcept C2776914184 @default.
• W2143758758 hasConcept C2779443120 @default.
• W2143758758 hasConcept C2780091579 @default.
• W2143758758 hasConcept C2780371755 @default.
• W2143758758 hasConcept C2781231759 @default.
• W2143758758 hasConcept C501593827 @default.
• W2143758758 hasConcept C71924100 @default.
• W2143758758 hasConcept C77411442 @default.
• W2143758758 hasConcept C86803240 @default.
• W2143758758 hasConcept C89423630 @default.
• W2143758758 hasConceptScore W2143758758C126322002 @default.
• W2143758758 hasConceptScore W2143758758C142724271 @default.
• W2143758758 hasConceptScore W2143758758C203014093 @default.
• W2143758758 hasConceptScore W2143758758C2776914184 @default.
• W2143758758 hasConceptScore W2143758758C2779443120 @default.
• W2143758758 hasConceptScore W2143758758C2780091579 @default.
• W2143758758 hasConceptScore W2143758758C2780371755 @default.
• W2143758758 hasConceptScore W2143758758C2781231759 @default.
• W2143758758 hasConceptScore W2143758758C501593827 @default.
• W2143758758 hasConceptScore W2143758758C71924100 @default.
• W2143758758 hasConceptScore W2143758758C77411442 @default.
• W2143758758 hasConceptScore W2143758758C86803240 @default.
• W2143758758 hasConceptScore W2143758758C89423630 @default.
• W2143758758 hasIssue "1" @default.
• W2143758758 hasLocation W21437587581 @default.
• W2143758758 hasLocation W21437587582 @default.
• W2143758758 hasLocation W21437587583 @default.
• W2143758758 hasLocation W21437587584 @default.
• W2143758758 hasOpenAccess W2143758758 @default.
• W2143758758 hasPrimaryLocation W21437587581 @default.
• W2143758758 hasRelatedWork W1486019900 @default.
• W2143758758 hasRelatedWork W1568223466 @default.
• W2143758758 hasRelatedWork W2017205529 @default.
• W2143758758 hasRelatedWork W2084602852 @default.
• W2143758758 hasRelatedWork W2152046643 @default.

• next