Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143765931> ?p ?o ?g. }
- W2143765931 endingPage "155" @default.
- W2143765931 startingPage "145" @default.
- W2143765931 abstract "Visceral leishmaniasis is characterized by severe immunosuppression of the host cell, resulting in loss of the proinflammatory response. Toll-like receptor 2 (TLR2) is involved in myriad disease forms, including visceral leishmaniasis. During Leishmania donovani infection, the parasite modulates TLR2 to suppress interleukin 12 production, indicating the possible involvement of TLR2 in regulation of the immune response against L. donovani infection. Arabinosylated lipoarabinomannan (Ara-LAM) possesses immunomodulatory properties and induces proinflammatory responses via induction of TLR2-mediated signaling. Here, we found that pretreatment of L. donovani-infected macrophages with Ara-LAM caused a significant increase in TLR2 expression along with the activation of TLR2-mediated downstream signaling, facilitating active nuclear translocation of nuclear factor κB. These events culminated in up-regulation of the proinflammatory response, which was abrogated by treatment with TLR2-specific small interfering RNA. In vivo experiments were also suggestive of Ara-LAM playing a long-term protective role. This study demonstrates that Ara-LAM confers protection against leishmanial pathogenesis via TLR2 signaling-mediated induction of the proinflammatory response." @default.
- W2143765931 created "2016-06-24" @default.
- W2143765931 creator A5006550633 @default.
- W2143765931 creator A5007896564 @default.
- W2143765931 creator A5024742527 @default.
- W2143765931 creator A5027477987 @default.
- W2143765931 creator A5042030122 @default.
- W2143765931 creator A5044782800 @default.
- W2143765931 creator A5049740675 @default.
- W2143765931 creator A5083535637 @default.
- W2143765931 creator A5088484714 @default.
- W2143765931 date "2010-07-01" @default.
- W2143765931 modified "2023-09-27" @default.
- W2143765931 title "Arabinosylated Lipoarabinomannan–Mediated Protection in Visceral Leishmaniasis through Up‐Regulation of Toll‐Like Receptor 2 Signaling: An Immunoprophylactic Approach" @default.
- W2143765931 cites W1490664191 @default.
- W2143765931 cites W1538916715 @default.
- W2143765931 cites W1569382726 @default.
- W2143765931 cites W1601816956 @default.
- W2143765931 cites W1830570844 @default.
- W2143765931 cites W1972261522 @default.
- W2143765931 cites W1972349011 @default.
- W2143765931 cites W1980139593 @default.
- W2143765931 cites W1984616248 @default.
- W2143765931 cites W1985622878 @default.
- W2143765931 cites W1990802251 @default.
- W2143765931 cites W1991943713 @default.
- W2143765931 cites W1994662946 @default.
- W2143765931 cites W2002026230 @default.
- W2143765931 cites W2018665009 @default.
- W2143765931 cites W2022607188 @default.
- W2143765931 cites W2057516079 @default.
- W2143765931 cites W2057618822 @default.
- W2143765931 cites W2060098125 @default.
- W2143765931 cites W2068592961 @default.
- W2143765931 cites W2078278171 @default.
- W2143765931 cites W2090110342 @default.
- W2143765931 cites W2092713838 @default.
- W2143765931 cites W2098083707 @default.
- W2143765931 cites W2101108802 @default.
- W2143765931 cites W2129087217 @default.
- W2143765931 cites W2138067578 @default.
- W2143765931 cites W2141710041 @default.
- W2143765931 cites W2146213573 @default.
- W2143765931 cites W2153095504 @default.
- W2143765931 cites W2156575228 @default.
- W2143765931 cites W2162726394 @default.
- W2143765931 cites W2164561211 @default.
- W2143765931 cites W2168930459 @default.
- W2143765931 cites W2406339952 @default.
- W2143765931 cites W39542338 @default.
- W2143765931 cites W2127642399 @default.
- W2143765931 doi "https://doi.org/10.1086/653210" @default.
- W2143765931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20500089" @default.
- W2143765931 hasPublicationYear "2010" @default.
- W2143765931 type Work @default.
- W2143765931 sameAs 2143765931 @default.
- W2143765931 citedByCount "38" @default.
- W2143765931 countsByYear W21437659312012 @default.
- W2143765931 countsByYear W21437659312013 @default.
- W2143765931 countsByYear W21437659312014 @default.
- W2143765931 countsByYear W21437659312015 @default.
- W2143765931 countsByYear W21437659312016 @default.
- W2143765931 countsByYear W21437659312017 @default.
- W2143765931 countsByYear W21437659312018 @default.
- W2143765931 countsByYear W21437659312019 @default.
- W2143765931 countsByYear W21437659312020 @default.
- W2143765931 countsByYear W21437659312022 @default.
- W2143765931 countsByYear W21437659312023 @default.
- W2143765931 crossrefType "journal-article" @default.
- W2143765931 hasAuthorship W2143765931A5006550633 @default.
- W2143765931 hasAuthorship W2143765931A5007896564 @default.
- W2143765931 hasAuthorship W2143765931A5024742527 @default.
- W2143765931 hasAuthorship W2143765931A5027477987 @default.
- W2143765931 hasAuthorship W2143765931A5042030122 @default.
- W2143765931 hasAuthorship W2143765931A5044782800 @default.
- W2143765931 hasAuthorship W2143765931A5049740675 @default.
- W2143765931 hasAuthorship W2143765931A5083535637 @default.
- W2143765931 hasAuthorship W2143765931A5088484714 @default.
- W2143765931 hasBestOaLocation W21437659311 @default.
- W2143765931 hasConcept C136449434 @default.
- W2143765931 hasConcept C142724271 @default.
- W2143765931 hasConcept C164027704 @default.
- W2143765931 hasConcept C203014093 @default.
- W2143765931 hasConcept C2776056871 @default.
- W2143765931 hasConcept C2776070231 @default.
- W2143765931 hasConcept C2776555147 @default.
- W2143765931 hasConcept C2776709828 @default.
- W2143765931 hasConcept C2776914184 @default.
- W2143765931 hasConcept C2777975735 @default.
- W2143765931 hasConcept C2778689377 @default.
- W2143765931 hasConcept C2781069245 @default.
- W2143765931 hasConcept C2781236682 @default.
- W2143765931 hasConcept C2781333301 @default.
- W2143765931 hasConcept C62478195 @default.
- W2143765931 hasConcept C71924100 @default.
- W2143765931 hasConcept C86803240 @default.
- W2143765931 hasConcept C8891405 @default.
- W2143765931 hasConcept C95444343 @default.