FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143781569> ?p ?o ?g. }

• W2143781569 endingPage "1722" @default.
• W2143781569 startingPage "1712" @default.
• W2143781569 abstract "OBJECTIVE—We reported that Smad1 is a key transcriptional factor for mesangial matrix expansion in diabetic nephropathy. In this study, we examined whether urinary Smad1 in an early phase of diabetes can predict later development of glomerulosclerosis in diabetic nephropathy and how an angiotensin II type 1 receptor blocker (ARB) can modulate structural changes and urinary markers. RESEARCH DESIGN AND METHODS—Smad1 and albumin in the urine were examined 4 weeks after injection of streptozotocin in 48 rats or 6 weeks of diabetes in db/db mice. Their renal pathology was analyzed after 20 weeks in rats or 12 weeks in mice. Among 48 diabetic rats 7 rats were treated with olmesartan for 20 weeks. RESULTS—Urinary Smad1 of diabetic rats at 4 weeks was nicely correlated with mesangial matrix expansion at 24 weeks (r = 0.70, P &lt; 0.001), while albuminuria showed a weaker association (r = 0.31, P = 0.043). Olmesartan treatment significantly ameliorated glomerulosclerosis and dramatically decreased urinary Smad1 (from 3.9 ± 2.9 to 0.3 ± 0.3 ng/mg creatinine, P &lt; 0.05). In db/db mice, urinary Smad1 at 6 weeks was also significantly correlated with mesangial expansion at 18 weeks. In contrast, there was no change in urinary Smad1 in control diabetic rats or mice. CONCLUSIONS—The increase of urinary Smad1 in the early stages of diabetes is correlated with later development of glomerulosclerosis in two rodent models. These data indicate that urinary Smad1 could be a novel predictor for later onset of morphological changes and can be used to monitor the effect of ARBs in diabetic nephropathy." @default.
• W2143781569 created "2016-06-24" @default.
• W2143781569 creator A5006856862 @default.
• W2143781569 creator A5009867090 @default.
• W2143781569 creator A5019170168 @default.
• W2143781569 creator A5026581043 @default.
• W2143781569 creator A5026761290 @default.
• W2143781569 creator A5033052103 @default.
• W2143781569 creator A5042280577 @default.
• W2143781569 creator A5051021923 @default.
• W2143781569 creator A5065746061 @default.
• W2143781569 creator A5069412789 @default.
• W2143781569 creator A5069467740 @default.
• W2143781569 creator A5071091023 @default.
• W2143781569 creator A5073743759 @default.
• W2143781569 creator A5075736574 @default.
• W2143781569 creator A5075757403 @default.
• W2143781569 creator A5076061467 @default.
• W2143781569 date "2008-06-01" @default.
• W2143781569 modified "2023-09-23" @default.
• W2143781569 title "Urinary Smad1 Is a Novel Marker to Predict Later Onset of Mesangial Matrix Expansion in Diabetic Nephropathy" @default.
• W2143781569 cites W1985941010 @default.
• W2143781569 cites W1986349550 @default.
• W2143781569 cites W1986454739 @default.
• W2143781569 cites W2012096008 @default.
• W2143781569 cites W2031809504 @default.
• W2143781569 cites W2044276013 @default.
• W2143781569 cites W2044773944 @default.
• W2143781569 cites W2050843664 @default.
• W2143781569 cites W2052658828 @default.
• W2143781569 cites W2056976690 @default.
• W2143781569 cites W2059788781 @default.
• W2143781569 cites W2061033381 @default.
• W2143781569 cites W2063420622 @default.
• W2143781569 cites W2064741730 @default.
• W2143781569 cites W2074965221 @default.
• W2143781569 cites W2075269747 @default.
• W2143781569 cites W2081619890 @default.
• W2143781569 cites W2096120926 @default.
• W2143781569 cites W2100829428 @default.
• W2143781569 cites W2110245532 @default.
• W2143781569 cites W2116397122 @default.
• W2143781569 cites W2118281486 @default.
• W2143781569 cites W2123365090 @default.
• W2143781569 cites W2123465605 @default.
• W2143781569 cites W2125486836 @default.
• W2143781569 cites W2130791906 @default.
• W2143781569 cites W2140262159 @default.
• W2143781569 cites W2151788147 @default.
• W2143781569 cites W2157734027 @default.
• W2143781569 cites W2168176104 @default.
• W2143781569 cites W2170753465 @default.
• W2143781569 cites W2326216471 @default.
• W2143781569 cites W2409521209 @default.
• W2143781569 cites W2615684303 @default.
• W2143781569 cites W4234245694 @default.
• W2143781569 cites W4249227027 @default.
• W2143781569 cites W4322702037 @default.
• W2143781569 doi "https://doi.org/10.2337/db07-1726" @default.
• W2143781569 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18285555" @default.
• W2143781569 hasPublicationYear "2008" @default.
• W2143781569 type Work @default.
• W2143781569 sameAs 2143781569 @default.
• W2143781569 citedByCount "50" @default.
• W2143781569 countsByYear W21437815692012 @default.
• W2143781569 countsByYear W21437815692013 @default.
• W2143781569 countsByYear W21437815692014 @default.
• W2143781569 countsByYear W21437815692015 @default.
• W2143781569 countsByYear W21437815692016 @default.
• W2143781569 countsByYear W21437815692017 @default.
• W2143781569 countsByYear W21437815692018 @default.
• W2143781569 countsByYear W21437815692019 @default.
• W2143781569 countsByYear W21437815692020 @default.
• W2143781569 countsByYear W21437815692021 @default.
• W2143781569 countsByYear W21437815692022 @default.
• W2143781569 countsByYear W21437815692023 @default.
• W2143781569 crossrefType "journal-article" @default.
• W2143781569 hasAuthorship W2143781569A5006856862 @default.
• W2143781569 hasAuthorship W2143781569A5009867090 @default.
• W2143781569 hasAuthorship W2143781569A5019170168 @default.
• W2143781569 hasAuthorship W2143781569A5026581043 @default.
• W2143781569 hasAuthorship W2143781569A5026761290 @default.
• W2143781569 hasAuthorship W2143781569A5033052103 @default.
• W2143781569 hasAuthorship W2143781569A5042280577 @default.
• W2143781569 hasAuthorship W2143781569A5051021923 @default.
• W2143781569 hasAuthorship W2143781569A5065746061 @default.
• W2143781569 hasAuthorship W2143781569A5069412789 @default.
• W2143781569 hasAuthorship W2143781569A5069467740 @default.
• W2143781569 hasAuthorship W2143781569A5071091023 @default.
• W2143781569 hasAuthorship W2143781569A5073743759 @default.
• W2143781569 hasAuthorship W2143781569A5075736574 @default.
• W2143781569 hasAuthorship W2143781569A5075757403 @default.
• W2143781569 hasAuthorship W2143781569A5076061467 @default.
• W2143781569 hasBestOaLocation W21437815691 @default.
• W2143781569 hasConcept C126322002 @default.
• W2143781569 hasConcept C126894567 @default.
• W2143781569 hasConcept C134018914 @default.
• W2143781569 hasConcept C2776174234 @default.

• next