FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143785085> ?p ?o ?g. }

• W2143785085 endingPage "2676" @default.
• W2143785085 startingPage "2673" @default.
• W2143785085 abstract "Endocarditis is the major clinical manifestation of chronic Q fever. Although doxycycline along with hydroxychloroquine remains the mainstay of medical therapy for Q fever endocarditis, there are wide variations in the rapidity of the patient's decline of antibody levels during such therapy. We undertook a retrospective examination of whether there was any correlation between the ratio of serum concentration to MIC of doxycycline and response to treatment in patients with Q fever endocarditis. Included herein are 16 patients from whom Coxiella burnetii was isolated from cardiac valve materials. Serology and measurement of doxycycline and hydroxychloroquine serum levels were performed and recorded after 1 year of treatment. The MIC of doxycycline for C. burnetii isolates was determined using the shell vial assay in a real-time quantitative PCR assay. At the completion of a year-long therapy with doxycycline-hydroxychloroquine, all those that showed a low decline of antibody levels (n = 6) (i.e., <2-fold decrease in antibody titer to phase I C. burnetii antigen) had a ratio of serum doxycycline concentration to MIC between 0.5 and 1. In contrast, those having a ratio of > or =1 showed a rapid decline of phase I antibody levels (n = 9; P < 0.05). The only patient who died had a serum doxycycline-to-MIC ratio of <0.5, and the isolate of C. burnetii cultured from this patient was resistant to doxycycline (MIC = 8 microg/ml). The ratio of serum doxycycline concentration to MIC should be monitored during the course of therapy in patients with Q fever endocarditis." @default.
• W2143785085 created "2016-06-24" @default.
• W2143785085 creator A5012670349 @default.
• W2143785085 creator A5021468261 @default.
• W2143785085 creator A5066555422 @default.
• W2143785085 creator A5074730004 @default.
• W2143785085 date "2005-07-01" @default.
• W2143785085 modified "2023-09-30" @default.
• W2143785085 title "Correlation between Ratio of Serum Doxycycline Concentration to MIC and Rapid Decline of Antibody Levels during Treatment of Q Fever Endocarditis" @default.
• W2143785085 cites W1774760650 @default.
• W2143785085 cites W1840405578 @default.
• W2143785085 cites W1953639336 @default.
• W2143785085 cites W1990005290 @default.
• W2143785085 cites W1998465006 @default.
• W2143785085 cites W2010513968 @default.
• W2143785085 cites W2032166985 @default.
• W2143785085 cites W2065959583 @default.
• W2143785085 cites W2080287073 @default.
• W2143785085 cites W2101798664 @default.
• W2143785085 cites W2103451304 @default.
• W2143785085 cites W2114449759 @default.
• W2143785085 cites W2115140994 @default.
• W2143785085 cites W2127857908 @default.
• W2143785085 cites W2134903749 @default.
• W2143785085 cites W2143505109 @default.
• W2143785085 cites W2148217180 @default.
• W2143785085 cites W2149432595 @default.
• W2143785085 cites W2161183972 @default.
• W2143785085 cites W2164687312 @default.
• W2143785085 cites W2166504426 @default.
• W2143785085 cites W4211219679 @default.
• W2143785085 doi "https://doi.org/10.1128/aac.49.7.2673-2676.2005" @default.
• W2143785085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1168648" @default.
• W2143785085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15980335" @default.
• W2143785085 hasPublicationYear "2005" @default.
• W2143785085 type Work @default.
• W2143785085 sameAs 2143785085 @default.
• W2143785085 citedByCount "60" @default.
• W2143785085 countsByYear W21437850852012 @default.
• W2143785085 countsByYear W21437850852013 @default.
• W2143785085 countsByYear W21437850852014 @default.
• W2143785085 countsByYear W21437850852015 @default.
• W2143785085 countsByYear W21437850852016 @default.
• W2143785085 countsByYear W21437850852017 @default.
• W2143785085 countsByYear W21437850852018 @default.
• W2143785085 countsByYear W21437850852019 @default.
• W2143785085 countsByYear W21437850852020 @default.
• W2143785085 countsByYear W21437850852021 @default.
• W2143785085 countsByYear W21437850852022 @default.
• W2143785085 crossrefType "journal-article" @default.
• W2143785085 hasAuthorship W2143785085A5012670349 @default.
• W2143785085 hasAuthorship W2143785085A5021468261 @default.
• W2143785085 hasAuthorship W2143785085A5066555422 @default.
• W2143785085 hasAuthorship W2143785085A5074730004 @default.
• W2143785085 hasBestOaLocation W21437850851 @default.
• W2143785085 hasConcept C126322002 @default.
• W2143785085 hasConcept C159047783 @default.
• W2143785085 hasConcept C159654299 @default.
• W2143785085 hasConcept C203014093 @default.
• W2143785085 hasConcept C2775872228 @default.
• W2143785085 hasConcept C2776607032 @default.
• W2143785085 hasConcept C2777179404 @default.
• W2143785085 hasConcept C2779123688 @default.
• W2143785085 hasConcept C2779134260 @default.
• W2143785085 hasConcept C2780731870 @default.
• W2143785085 hasConcept C3008058167 @default.
• W2143785085 hasConcept C45189115 @default.
• W2143785085 hasConcept C501593827 @default.
• W2143785085 hasConcept C524204448 @default.
• W2143785085 hasConcept C71924100 @default.
• W2143785085 hasConcept C86803240 @default.
• W2143785085 hasConcept C89423630 @default.
• W2143785085 hasConcept C90924648 @default.
• W2143785085 hasConceptScore W2143785085C126322002 @default.
• W2143785085 hasConceptScore W2143785085C159047783 @default.
• W2143785085 hasConceptScore W2143785085C159654299 @default.
• W2143785085 hasConceptScore W2143785085C203014093 @default.
• W2143785085 hasConceptScore W2143785085C2775872228 @default.
• W2143785085 hasConceptScore W2143785085C2776607032 @default.
• W2143785085 hasConceptScore W2143785085C2777179404 @default.
• W2143785085 hasConceptScore W2143785085C2779123688 @default.
• W2143785085 hasConceptScore W2143785085C2779134260 @default.
• W2143785085 hasConceptScore W2143785085C2780731870 @default.
• W2143785085 hasConceptScore W2143785085C3008058167 @default.
• W2143785085 hasConceptScore W2143785085C45189115 @default.
• W2143785085 hasConceptScore W2143785085C501593827 @default.
• W2143785085 hasConceptScore W2143785085C524204448 @default.
• W2143785085 hasConceptScore W2143785085C71924100 @default.
• W2143785085 hasConceptScore W2143785085C86803240 @default.
• W2143785085 hasConceptScore W2143785085C89423630 @default.
• W2143785085 hasConceptScore W2143785085C90924648 @default.
• W2143785085 hasIssue "7" @default.
• W2143785085 hasLocation W21437850851 @default.
• W2143785085 hasLocation W21437850852 @default.
• W2143785085 hasLocation W21437850853 @default.
• W2143785085 hasLocation W21437850854 @default.
• W2143785085 hasOpenAccess W2143785085 @default.
• W2143785085 hasPrimaryLocation W21437850851 @default.

• next