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- W2143804584 abstract "Emerging evidence has displayed that oxygen free radicals especially ones promoted by free iron play an important role in the development of alcoholic liver disease (ALD). Naturally-occurring quercetin has been reported to prevent ALD and iron overload-induced damage aside from the free iron. The purpose was to explore the potential mechanisms by which quercetin arrests alcohol-induced free iron disorder. Chronic alcohol (30% of total calories) or iron (0.2%)-fed adult male C57BL/J mice for 15 weeks resulted in significantly elevated levels of hepatic iron, labile iron pool-Fe and serum non-transferrin bound iron, accompanied with sustained oxidative damage. The hepatotoxicity was further exacerbated by ethanol and iron. Quercetin (100 mg/kg. body weight) alleviated the detrimental effects induced by ethanol and/or iron. The expressions of divalent metal transporter 1, zinc transporter member 14, mucolipin 1, transferrin receptor 1 (TfR1) and ferritin were up-regulated by ethanol and/or iron, which were partially normalized by quercetin. Quercetin prevented ethanol-induced hepatotoxicity, which may be partially attributed to the alleviated disorder of bound iron and free iron. The significant suppression of ethanol-stimulated molecules for free iron uptake and release may contribute to the hepatoprotective effect of quercetin, although TfR1-mediated physiological pathway of iron uptake also played a role." @default.
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- W2143804584 date "2014-05-01" @default.
- W2143804584 modified "2023-10-07" @default.
- W2143804584 title "Quercetin attenuates chronic ethanol hepatotoxicity: Implication of “free” iron uptake and release" @default.
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- W2143804584 doi "https://doi.org/10.1016/j.fct.2014.02.022" @default.
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