FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143804678> ?p ?o ?g. }

• W2143804678 endingPage "684" @default.
• W2143804678 startingPage "676" @default.
• W2143804678 abstract "Abstract Background and Aim Most studies focus on gut‐derived factors like microbiota and its products and how they contribute to non‐alcoholic fatty liver disease (NAFLD) progression. This study investigated whether the gut‐derived lymphocytes could migrate to the liver and induce liver injury in NAFLD. Methods A high‐fat diet induced an NAFLD mouse model, and lymphocytes were labeled with 1,1‐dioctadecyl‐3,3,3,3 tetramethylindotricarbocyanine iodide and carboxy‐fluorescein succinimidyl ester, respectively, and intravenously injected to mice to monitor lymphocyte migration. Results Adoptive transfer model results indicated that compared with lymphocytes from the spleen, bone marrow and thymus of NAFLD donor mice, mesenteric lymph nodes (MLN) cells from NAFLD donor mice predominately accumulated in the livers of NAFLD recipient mice. The frequencies of central memory CD4 + T and CD8 + T cells in livers of NAFLD mice were significantly increased; however, the activated T cells were not significantly altered. After adoptively transferred MLN cells, the frequencies of the activated CD4 + T and CD8 + T cells increased in livers of NAFLD recipient mice. By contrast, the frequencies of central memory and naïve CD4 + T and CD8 + T cells decreased. MLN cells also induced liver injury in NAFLD recipient mice, as reflected by elevated serum alanine aminotransferase and glutamic oxaloacetic transaminase serums. Moreover, the chemotaxis assay showed that CCL5 mediated the MLN cell migration to the liver. Also, blocking the CCL5 inhibited MLN cell migration to the liver in vitro . Conclusions Gut‐derived lymphocytes from NAFLD mice could migrate to the liver and induce liver injury and hepatic CD4 + T and CD8 + T cells activation. The migration was associated with the upregulation of CCL5 in the liver." @default.
• W2143804678 created "2016-06-24" @default.
• W2143804678 creator A5005410370 @default.
• W2143804678 creator A5013169202 @default.
• W2143804678 creator A5015849886 @default.
• W2143804678 creator A5034012227 @default.
• W2143804678 creator A5043360958 @default.
• W2143804678 creator A5078004886 @default.
• W2143804678 creator A5083090268 @default.
• W2143804678 creator A5087443544 @default.
• W2143804678 date "2016-02-26" @default.
• W2143804678 modified "2023-10-03" @default.
• W2143804678 title "Gut-derived lymphocyte recruitment to liver and induce liver injury in non-alcoholic fatty liver disease mouse model" @default.
• W2143804678 cites W1572116485 @default.
• W2143804678 cites W1849406318 @default.
• W2143804678 cites W1963683487 @default.
• W2143804678 cites W1967221083 @default.
• W2143804678 cites W1967972402 @default.
• W2143804678 cites W1973826653 @default.
• W2143804678 cites W1977043587 @default.
• W2143804678 cites W1984916935 @default.
• W2143804678 cites W2005553679 @default.
• W2143804678 cites W2011709384 @default.
• W2143804678 cites W2020153444 @default.
• W2143804678 cites W2026781960 @default.
• W2143804678 cites W2030407395 @default.
• W2143804678 cites W2037271656 @default.
• W2143804678 cites W2062274484 @default.
• W2143804678 cites W2065612971 @default.
• W2143804678 cites W2080755877 @default.
• W2143804678 cites W2086648828 @default.
• W2143804678 cites W2131748930 @default.
• W2143804678 cites W2141158324 @default.
• W2143804678 cites W2144275312 @default.
• W2143804678 cites W2144499863 @default.
• W2143804678 cites W2167543058 @default.
• W2143804678 doi "https://doi.org/10.1111/jgh.13183" @default.
• W2143804678 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26430807" @default.
• W2143804678 hasPublicationYear "2016" @default.
• W2143804678 type Work @default.
• W2143804678 sameAs 2143804678 @default.
• W2143804678 citedByCount "28" @default.
• W2143804678 countsByYear W21438046782016 @default.
• W2143804678 countsByYear W21438046782017 @default.
• W2143804678 countsByYear W21438046782018 @default.
• W2143804678 countsByYear W21438046782019 @default.
• W2143804678 countsByYear W21438046782020 @default.
• W2143804678 countsByYear W21438046782021 @default.
• W2143804678 countsByYear W21438046782022 @default.
• W2143804678 countsByYear W21438046782023 @default.
• W2143804678 crossrefType "journal-article" @default.
• W2143804678 hasAuthorship W2143804678A5005410370 @default.
• W2143804678 hasAuthorship W2143804678A5013169202 @default.
• W2143804678 hasAuthorship W2143804678A5015849886 @default.
• W2143804678 hasAuthorship W2143804678A5034012227 @default.
• W2143804678 hasAuthorship W2143804678A5043360958 @default.
• W2143804678 hasAuthorship W2143804678A5078004886 @default.
• W2143804678 hasAuthorship W2143804678A5083090268 @default.
• W2143804678 hasAuthorship W2143804678A5087443544 @default.
• W2143804678 hasConcept C126322002 @default.
• W2143804678 hasConcept C134018914 @default.
• W2143804678 hasConcept C154317977 @default.
• W2143804678 hasConcept C167672396 @default.
• W2143804678 hasConcept C202751555 @default.
• W2143804678 hasConcept C203014093 @default.
• W2143804678 hasConcept C2776090121 @default.
• W2143804678 hasConcept C2776637226 @default.
• W2143804678 hasConcept C2777761686 @default.
• W2143804678 hasConcept C2778772119 @default.
• W2143804678 hasConcept C2779134260 @default.
• W2143804678 hasConcept C2779478299 @default.
• W2143804678 hasConcept C2780931953 @default.
• W2143804678 hasConcept C55493867 @default.
• W2143804678 hasConcept C71924100 @default.
• W2143804678 hasConcept C86803240 @default.
• W2143804678 hasConcept C8891405 @default.
• W2143804678 hasConcept C90375314 @default.
• W2143804678 hasConceptScore W2143804678C126322002 @default.
• W2143804678 hasConceptScore W2143804678C134018914 @default.
• W2143804678 hasConceptScore W2143804678C154317977 @default.
• W2143804678 hasConceptScore W2143804678C167672396 @default.
• W2143804678 hasConceptScore W2143804678C202751555 @default.
• W2143804678 hasConceptScore W2143804678C203014093 @default.
• W2143804678 hasConceptScore W2143804678C2776090121 @default.
• W2143804678 hasConceptScore W2143804678C2776637226 @default.
• W2143804678 hasConceptScore W2143804678C2777761686 @default.
• W2143804678 hasConceptScore W2143804678C2778772119 @default.
• W2143804678 hasConceptScore W2143804678C2779134260 @default.
• W2143804678 hasConceptScore W2143804678C2779478299 @default.
• W2143804678 hasConceptScore W2143804678C2780931953 @default.
• W2143804678 hasConceptScore W2143804678C55493867 @default.
• W2143804678 hasConceptScore W2143804678C71924100 @default.
• W2143804678 hasConceptScore W2143804678C86803240 @default.
• W2143804678 hasConceptScore W2143804678C8891405 @default.
• W2143804678 hasConceptScore W2143804678C90375314 @default.
• W2143804678 hasFunder F4320321001 @default.
• W2143804678 hasIssue "3" @default.
• W2143804678 hasLocation W21438046781 @default.

• next