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• W2143805188 abstract "Protein tyrosine kinase Pyk2 and multifunctional adaptor protein Cbl are implicated in the regulation of the cytoskeleton in several cell types. We report that Pyk2 and Cbl form a signaling complex that is translocated to lipid rafts and is enriched in growth cones of differentiating PC12 cells following growth factor stimulation. We found that Pyk2 and Cbl interacted with the adaptor protein ArgBP2, which also bound to flotillin-1, a component of lipid raft microdomains. These interactions contributed to recruitment of the Pyk2/Cbl complex to lipid raft compartments. In addition, Pyk2, Cbl and ArgBP2 were found co-localized with actin in axons and growth cones of differentiated PC12 cells. Moreover, co-expression of Pyk2, ArgBP2 and Cbl facilitated growth factor-induced formation of lamellipodia at the tip of neurites. Formation of these growth cone lamellipodia was dependent on intact lipid rafts and the Cbl-associated effectors Crk and phosphatidylinositol 3 (PI 3)-kinase. Our results indicate that recruitment of Pyk2/Cbl complexes to lipid rafts participates in growth factor-induced regulation of the actin cytoskeleton in growing neurites." @default.
• W2143805188 created "2016-06-24" @default.
• W2143805188 creator A5052435188 @default.
• W2143805188 date "2004-01-01" @default.
• W2143805188 modified "2023-09-27" @default.
• W2143805188 title "Ubiquitination and Receptor Endocytosis" @default.
• W2143805188 cites W1494477854 @default.
• W2143805188 cites W1497941038 @default.
• W2143805188 cites W1499176799 @default.
• W2143805188 cites W1509361070 @default.
• W2143805188 cites W1510287295 @default.
• W2143805188 cites W1513014113 @default.
• W2143805188 cites W1523314824 @default.
• W2143805188 cites W1527673674 @default.
• W2143805188 cites W1535731511 @default.
• W2143805188 cites W1538471627 @default.
• W2143805188 cites W1548893012 @default.
• W2143805188 cites W1550712876 @default.
• W2143805188 cites W1553799143 @default.
• W2143805188 cites W1564784444 @default.
• W2143805188 cites W1564861448 @default.
• W2143805188 cites W1565398585 @default.
• W2143805188 cites W1571287379 @default.
• W2143805188 cites W1577573926 @default.
• W2143805188 cites W1585236678 @default.
• W2143805188 cites W1591503704 @default.
• W2143805188 cites W1595083713 @default.
• W2143805188 cites W1596079370 @default.
• W2143805188 cites W1598659248 @default.
• W2143805188 cites W1599518523 @default.
• W2143805188 cites W1608914198 @default.
• W2143805188 cites W1612998887 @default.
• W2143805188 cites W1614056212 @default.
• W2143805188 cites W1634344740 @default.
• W2143805188 cites W1639582946 @default.
• W2143805188 cites W164994551 @default.
• W2143805188 cites W1665419471 @default.
• W2143805188 cites W1666806163 @default.
• W2143805188 cites W170428794 @default.
• W2143805188 cites W1709099666 @default.
• W2143805188 cites W1753563681 @default.
• W2143805188 cites W1780544763 @default.
• W2143805188 cites W1832030339 @default.
• W2143805188 cites W1854589240 @default.
• W2143805188 cites W1874958320 @default.
• W2143805188 cites W1875616293 @default.
• W2143805188 cites W1896542943 @default.
• W2143805188 cites W1930762285 @default.
• W2143805188 cites W1931780528 @default.
• W2143805188 cites W1938129101 @default.
• W2143805188 cites W1960171220 @default.
• W2143805188 cites W1964021682 @default.
• W2143805188 cites W1964149678 @default.
• W2143805188 cites W1964261321 @default.
• W2143805188 cites W1964321121 @default.
• W2143805188 cites W1964504843 @default.
• W2143805188 cites W1965028987 @default.
• W2143805188 cites W1965283067 @default.
• W2143805188 cites W1965476757 @default.
• W2143805188 cites W1965951015 @default.
• W2143805188 cites W1966658428 @default.
• W2143805188 cites W1967343277 @default.
• W2143805188 cites W1969309483 @default.
• W2143805188 cites W1969958451 @default.
• W2143805188 cites W1970920351 @default.
• W2143805188 cites W1972242729 @default.
• W2143805188 cites W1975510716 @default.
• W2143805188 cites W1976860461 @default.
• W2143805188 cites W1977178070 @default.
• W2143805188 cites W1977253956 @default.
• W2143805188 cites W1978002465 @default.
• W2143805188 cites W1978994762 @default.
• W2143805188 cites W1979171720 @default.
• W2143805188 cites W1979274256 @default.
• W2143805188 cites W1981096579 @default.
• W2143805188 cites W1981228379 @default.
• W2143805188 cites W1982178099 @default.
• W2143805188 cites W1982186905 @default.
• W2143805188 cites W1982210988 @default.
• W2143805188 cites W1983089513 @default.
• W2143805188 cites W1983523339 @default.
• W2143805188 cites W1984168124 @default.
• W2143805188 cites W1984318054 @default.
• W2143805188 cites W1984375602 @default.
• W2143805188 cites W1984872320 @default.
• W2143805188 cites W1987219070 @default.
• W2143805188 cites W1987736310 @default.
• W2143805188 cites W1988681657 @default.
• W2143805188 cites W1988873174 @default.
• W2143805188 cites W1989642116 @default.
• W2143805188 cites W1989740989 @default.
• W2143805188 cites W1989970319 @default.
• W2143805188 cites W1990641591 @default.
• W2143805188 cites W1991691364 @default.
• W2143805188 cites W1992139451 @default.
• W2143805188 cites W1994993681 @default.
• W2143805188 cites W1995223052 @default.
• W2143805188 cites W1995574514 @default.
• W2143805188 cites W1995819749 @default.
• W2143805188 cites W1996204979 @default.

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