FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143893513> ?p ?o ?g. }

• W2143893513 endingPage "1744" @default.
• W2143893513 startingPage "1735" @default.
• W2143893513 abstract "Domain swapping is a type of oligomerization in which monomeric proteins exchange a structural element, resulting in oligomers whose subunits recapitulate the native, monomeric fold. It has been implicated as a potential mechanism for protein aggregation, which provides a strong impetus to understand the structural determinants and folding mechanisms that trigger domain swapping. Bovine pancreatic ribonuclease A (RNase A) is a well-studied protein known to domain swap under extreme conditions, such as lyophilization from acetic acid. The major domain-swapped dimer form of RNase A exchanges a β-strand at its C-terminus to form a C-terminal domain-swapped dimer. To study the mechanism by which C-terminal swapping occurs, we used a variant of RNase A containing a P114G mutation that readily domain swaps under physiological conditions. Using NMR and hydrogen-deuterium exchange, we find that the P114G variant has decreased protection from hydrogen exchange compared to the wild-type protein near the C-terminal hinge region. Our results suggest that domain swapping occurs via a local high-energy fluctuation at the C-terminus." @default.
• W2143893513 created "2016-06-24" @default.
• W2143893513 creator A5043858304 @default.
• W2143893513 creator A5053849238 @default.
• W2143893513 date "2011-09-12" @default.
• W2143893513 modified "2023-10-14" @default.
• W2143893513 title "Propensity for C-terminal domain swapping correlates with increased regional flexibility in the C-terminus of RNase A" @default.
• W2143893513 cites W1499408335 @default.
• W2143893513 cites W1537264614 @default.
• W2143893513 cites W1590313270 @default.
• W2143893513 cites W1964356199 @default.
• W2143893513 cites W1981168662 @default.
• W2143893513 cites W1995543945 @default.
• W2143893513 cites W2009639101 @default.
• W2143893513 cites W2026132887 @default.
• W2143893513 cites W2030910935 @default.
• W2143893513 cites W2038263678 @default.
• W2143893513 cites W2045820581 @default.
• W2143893513 cites W2050323921 @default.
• W2143893513 cites W2055501963 @default.
• W2143893513 cites W2061107874 @default.
• W2143893513 cites W2062093594 @default.
• W2143893513 cites W2067509872 @default.
• W2143893513 cites W2069478089 @default.
• W2143893513 cites W2074410056 @default.
• W2143893513 cites W2076619122 @default.
• W2143893513 cites W2078344160 @default.
• W2143893513 cites W2089642129 @default.
• W2143893513 cites W2092594677 @default.
• W2143893513 cites W2103598875 @default.
• W2143893513 cites W2109939279 @default.
• W2143893513 cites W2114320763 @default.
• W2143893513 cites W2128780962 @default.
• W2143893513 cites W2155976983 @default.
• W2143893513 cites W2169821755 @default.
• W2143893513 doi "https://doi.org/10.1002/pro.708" @default.
• W2143893513 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3218367" @default.
• W2143893513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21805524" @default.
• W2143893513 hasPublicationYear "2011" @default.
• W2143893513 type Work @default.
• W2143893513 sameAs 2143893513 @default.
• W2143893513 citedByCount "7" @default.
• W2143893513 countsByYear W21438935132012 @default.
• W2143893513 countsByYear W21438935132013 @default.
• W2143893513 countsByYear W21438935132016 @default.
• W2143893513 countsByYear W21438935132019 @default.
• W2143893513 countsByYear W21438935132020 @default.
• W2143893513 countsByYear W21438935132022 @default.
• W2143893513 crossrefType "journal-article" @default.
• W2143893513 hasAuthorship W2143893513A5043858304 @default.
• W2143893513 hasAuthorship W2143893513A5053849238 @default.
• W2143893513 hasBestOaLocation W21438935131 @default.
• W2143893513 hasConcept C104317684 @default.
• W2143893513 hasConcept C10879258 @default.
• W2143893513 hasConcept C12554922 @default.
• W2143893513 hasConcept C167569220 @default.
• W2143893513 hasConcept C178790620 @default.
• W2143893513 hasConcept C185592680 @default.
• W2143893513 hasConcept C204328495 @default.
• W2143893513 hasConcept C2778976237 @default.
• W2143893513 hasConcept C2779546866 @default.
• W2143893513 hasConcept C47701112 @default.
• W2143893513 hasConcept C512968161 @default.
• W2143893513 hasConcept C515207424 @default.
• W2143893513 hasConcept C55493867 @default.
• W2143893513 hasConcept C57711820 @default.
• W2143893513 hasConcept C67705224 @default.
• W2143893513 hasConcept C69766542 @default.
• W2143893513 hasConcept C71240020 @default.
• W2143893513 hasConcept C86803240 @default.
• W2143893513 hasConceptScore W2143893513C104317684 @default.
• W2143893513 hasConceptScore W2143893513C10879258 @default.
• W2143893513 hasConceptScore W2143893513C12554922 @default.
• W2143893513 hasConceptScore W2143893513C167569220 @default.
• W2143893513 hasConceptScore W2143893513C178790620 @default.
• W2143893513 hasConceptScore W2143893513C185592680 @default.
• W2143893513 hasConceptScore W2143893513C204328495 @default.
• W2143893513 hasConceptScore W2143893513C2778976237 @default.
• W2143893513 hasConceptScore W2143893513C2779546866 @default.
• W2143893513 hasConceptScore W2143893513C47701112 @default.
• W2143893513 hasConceptScore W2143893513C512968161 @default.
• W2143893513 hasConceptScore W2143893513C515207424 @default.
• W2143893513 hasConceptScore W2143893513C55493867 @default.
• W2143893513 hasConceptScore W2143893513C57711820 @default.
• W2143893513 hasConceptScore W2143893513C67705224 @default.
• W2143893513 hasConceptScore W2143893513C69766542 @default.
• W2143893513 hasConceptScore W2143893513C71240020 @default.
• W2143893513 hasConceptScore W2143893513C86803240 @default.
• W2143893513 hasIssue "10" @default.
• W2143893513 hasLocation W21438935131 @default.
• W2143893513 hasLocation W21438935132 @default.
• W2143893513 hasLocation W21438935133 @default.
• W2143893513 hasLocation W21438935134 @default.
• W2143893513 hasOpenAccess W2143893513 @default.
• W2143893513 hasPrimaryLocation W21438935131 @default.
• W2143893513 hasRelatedWork W1983545735 @default.
• W2143893513 hasRelatedWork W2036911034 @default.
• W2143893513 hasRelatedWork W2061976424 @default.

• next