FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143898155> ?p ?o ?g. }

• W2143898155 endingPage "203" @default.
• W2143898155 startingPage "202" @default.
• W2143898155 abstract "An important minority of patients (19–44%) with gastro-oesophageal reflux disease (GERD) remain symptomatic, and/or have demonstrable reflux, despite high-dose antisecretory therapy.1-5 Baclofen, used off label for refractory reflux treatment,6, 7 has side effects limiting long-term use, and development of other reflux inhibitors has been curtailed. So, few pharmacological options are available to treat refractory patients. Sweis and colleagues8 have employed a modern technological approach to revisit, study and compare two long available agents: an alginate–antacid preparation (Gaviscon Advance [GA]; Reckitt Benckiser, Slough, UK) to a simple antacid (Milk of Magnesia; Boots, Nottingham, UK; Alucol). They used magnetic resonance imaging (MRI) in healthy volunteers, 30 min following ingestion of a standardised meal, and elegantly demonstrated that the alginate–antacid preparation, GA, forms a ‘mass’ between the gastro-oesophageal junction (GEJ) and the solid meal, while the simple antacid, ‘sinks’ to the bottom of the stomach. In addition, intragastric GA volume was greater (53 vs. 19 mL P < 0.03) and the centre of the GA mass was closer to the GEJ than the simple antacid (3 vs. 10 cm P < 0.001). High-resolution manometry demonstrated, by common cavity, fewer reflux events with GA than the simple antacid in the post-prandial period (2 vs. 5, P < 0.035). The authors then performed a randomised cross-over study of symptomatic patients using 28 h of impedance/pH monitoring (with a 20-h ambulatory and two 4-h stationary periods) and standardised provocative meals. Other than a trend towards a decrease in the number of proximal reflux events in the GA group (10.5 vs. 13.9 P = 0.07), there were no differences between the two agents in reflux control. What is missing from the analysis is specific attention to the post-prandial periods (with and without provocation) where GA is likely to be most effective. Perhaps, the authors will consider a post hoc analysis of those periods. This study definitively shows by MRI imaging that an alginate–antacid preparation GA can provide a barrier to meal stimulated acid reflux, and offer superior acid control in the important region of the GEJ than a simple antacid alone. The trend towards decrease in proximal reflux episodes, which are more likely to produce symptoms in patients with incomplete relief on PPIs,9 offers hope that a product like this inexpensive and safe over the counter agent may offer symptom relief in patients with post-prandial heartburn and regurgitation. The GA sold in the United States is not identical to that the authors studied. The US brand of GA contains less sodium alginate, which may affect these results. We look forward to further studies in larger numbers of refractory GERD patients to better substantiate these findings. Declaration of personal and funding interests: None." @default.
• W2143898155 created "2016-06-24" @default.
• W2143898155 creator A5016023883 @default.
• W2143898155 creator A5071897060 @default.
• W2143898155 date "2013-06-17" @default.
• W2143898155 modified "2023-10-16" @default.
• W2143898155 title "Commentary: revisiting the past - does it hold the key to the future treatment of refractory GERD?" @default.
• W2143898155 cites W1493398797 @default.
• W2143898155 cites W1727558214 @default.
• W2143898155 cites W1998052119 @default.
• W2143898155 cites W1999600314 @default.
• W2143898155 cites W2017554369 @default.
• W2143898155 cites W2072925621 @default.
• W2143898155 cites W2094149744 @default.
• W2143898155 cites W2110322996 @default.
• W2143898155 cites W2143285572 @default.
• W2143898155 doi "https://doi.org/10.1111/apt.12346" @default.
• W2143898155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23772900" @default.
• W2143898155 hasPublicationYear "2013" @default.
• W2143898155 type Work @default.
• W2143898155 sameAs 2143898155 @default.
• W2143898155 citedByCount "1" @default.
• W2143898155 countsByYear W21438981552013 @default.
• W2143898155 crossrefType "journal-article" @default.
• W2143898155 hasAuthorship W2143898155A5016023883 @default.
• W2143898155 hasAuthorship W2143898155A5071897060 @default.
• W2143898155 hasBestOaLocation W21438981551 @default.
• W2143898155 hasConcept C121332964 @default.
• W2143898155 hasConcept C126322002 @default.
• W2143898155 hasConcept C142424586 @default.
• W2143898155 hasConcept C2777014526 @default.
• W2143898155 hasConcept C2779134260 @default.
• W2143898155 hasConcept C2779422922 @default.
• W2143898155 hasConcept C2780590083 @default.
• W2143898155 hasConcept C2781025758 @default.
• W2143898155 hasConcept C3020479747 @default.
• W2143898155 hasConcept C43270747 @default.
• W2143898155 hasConcept C71924100 @default.
• W2143898155 hasConcept C87355193 @default.
• W2143898155 hasConcept C90924648 @default.
• W2143898155 hasConceptScore W2143898155C121332964 @default.
• W2143898155 hasConceptScore W2143898155C126322002 @default.
• W2143898155 hasConceptScore W2143898155C142424586 @default.
• W2143898155 hasConceptScore W2143898155C2777014526 @default.
• W2143898155 hasConceptScore W2143898155C2779134260 @default.
• W2143898155 hasConceptScore W2143898155C2779422922 @default.
• W2143898155 hasConceptScore W2143898155C2780590083 @default.
• W2143898155 hasConceptScore W2143898155C2781025758 @default.
• W2143898155 hasConceptScore W2143898155C3020479747 @default.
• W2143898155 hasConceptScore W2143898155C43270747 @default.
• W2143898155 hasConceptScore W2143898155C71924100 @default.
• W2143898155 hasConceptScore W2143898155C87355193 @default.
• W2143898155 hasConceptScore W2143898155C90924648 @default.
• W2143898155 hasIssue "2" @default.
• W2143898155 hasLocation W21438981551 @default.
• W2143898155 hasLocation W21438981552 @default.
• W2143898155 hasOpenAccess W2143898155 @default.
• W2143898155 hasPrimaryLocation W21438981551 @default.
• W2143898155 hasRelatedWork W1972259282 @default.
• W2143898155 hasRelatedWork W1977139604 @default.
• W2143898155 hasRelatedWork W1995948735 @default.
• W2143898155 hasRelatedWork W2002764668 @default.
• W2143898155 hasRelatedWork W2015661160 @default.
• W2143898155 hasRelatedWork W2029987021 @default.
• W2143898155 hasRelatedWork W2050363796 @default.
• W2143898155 hasRelatedWork W2051086238 @default.
• W2143898155 hasRelatedWork W2473723399 @default.
• W2143898155 hasRelatedWork W3141404013 @default.
• W2143898155 hasVolume "38" @default.
• W2143898155 isParatext "false" @default.
• W2143898155 isRetracted "false" @default.
• W2143898155 magId "2143898155" @default.
• W2143898155 workType "article" @default.