FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143899076> ?p ?o ?g. }

• W2143899076 endingPage "2343" @default.
• W2143899076 startingPage "2333" @default.
• W2143899076 abstract "We have investigated the molecular mechanisms involved in 17 beta-estradiol-induced angiogenic pathway. We show here that 17 beta-estradiol promoted a 6-fold increase in Jagged1 expression and an 8-fold increase in Notch1 expression by cDNA arrays in breast cancer MCF7 cells. Interestingly, Jagged1 was abrogated by incubation with the estrogen antagonist, ICI182,780. A similar up-regulation of both Notch1 receptor and Jagged1 ligand was found in endothelial cells. Additionally, imperfect estrogen-responsive elements were found in the 5' untranslated region of Notch1 and Jagged1 genes. Treatment with 17 beta-estradiol also led to an activation of Notch signaling in MCF7 cells expressing Notch1 reporter gene or by promoting Jagged1-induced Notch signaling in coculture assays. Inoculation of MCF7 cells in 17 beta-estradiol-treated nude mice resulted in up-regulation of Notch1 expression as well as increased number of tumor microvessels in comparison to placebo-treated mice. Notch1-expressing endothelial cell cultures formed cord-like structures on Matrigel in contrast to cells expressing a dominant-negative form of Notch1, emphasizing the relevance of Notch1 pathway in vessel assembly. Finally, Notch1-expressing MCF7 cells up-regulated hypoxia-inducible factor 1 alpha gene, a well-known angiogenic factor that clustered with Notch1 gene. This study implicates Notch signaling in the cross talk between 17 beta-estradiol and angiogenesis." @default.
• W2143899076 created "2016-06-24" @default.
• W2143899076 creator A5001917541 @default.
• W2143899076 creator A5028767906 @default.
• W2143899076 creator A5039216989 @default.
• W2143899076 creator A5040560862 @default.
• W2143899076 creator A5046511241 @default.
• W2143899076 creator A5049513875 @default.
• W2143899076 date "2004-09-01" @default.
• W2143899076 modified "2023-10-13" @default.
• W2143899076 title "Evidence for the Notch Signaling Pathway on the Role of Estrogen in Angiogenesis" @default.
• W2143899076 cites W109501640 @default.
• W2143899076 cites W1515648506 @default.
• W2143899076 cites W1656339735 @default.
• W2143899076 cites W1921041263 @default.
• W2143899076 cites W1965963514 @default.
• W2143899076 cites W1968068296 @default.
• W2143899076 cites W1970832400 @default.
• W2143899076 cites W1970846841 @default.
• W2143899076 cites W1973038628 @default.
• W2143899076 cites W1996910230 @default.
• W2143899076 cites W1997098009 @default.
• W2143899076 cites W1997118698 @default.
• W2143899076 cites W2007704060 @default.
• W2143899076 cites W2011723510 @default.
• W2143899076 cites W2018527149 @default.
• W2143899076 cites W2022018022 @default.
• W2143899076 cites W2028162650 @default.
• W2143899076 cites W2028817453 @default.
• W2143899076 cites W2029253199 @default.
• W2143899076 cites W2030437674 @default.
• W2143899076 cites W2031380629 @default.
• W2143899076 cites W2042240304 @default.
• W2143899076 cites W2051109788 @default.
• W2143899076 cites W2051319925 @default.
• W2143899076 cites W2054962905 @default.
• W2143899076 cites W2058733797 @default.
• W2143899076 cites W2075238507 @default.
• W2143899076 cites W2082839004 @default.
• W2143899076 cites W2084597093 @default.
• W2143899076 cites W2086645076 @default.
• W2143899076 cites W2091096050 @default.
• W2143899076 cites W2093395873 @default.
• W2143899076 cites W2094838095 @default.
• W2143899076 cites W2097625541 @default.
• W2143899076 cites W2111513247 @default.
• W2143899076 cites W2114868315 @default.
• W2143899076 cites W2123478725 @default.
• W2143899076 cites W2129124160 @default.
• W2143899076 cites W2133469704 @default.
• W2143899076 cites W2140583698 @default.
• W2143899076 cites W2147315723 @default.
• W2143899076 cites W2154861644 @default.
• W2143899076 cites W2159206513 @default.
• W2143899076 cites W2161672871 @default.
• W2143899076 cites W2167582537 @default.
• W2143899076 cites W2330560210 @default.
• W2143899076 cites W2428876759 @default.
• W2143899076 cites W2615633554 @default.
• W2143899076 doi "https://doi.org/10.1210/me.2003-0362" @default.
• W2143899076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15192074" @default.
• W2143899076 hasPublicationYear "2004" @default.
• W2143899076 type Work @default.
• W2143899076 sameAs 2143899076 @default.
• W2143899076 citedByCount "130" @default.
• W2143899076 countsByYear W21438990762012 @default.
• W2143899076 countsByYear W21438990762013 @default.
• W2143899076 countsByYear W21438990762014 @default.
• W2143899076 countsByYear W21438990762015 @default.
• W2143899076 countsByYear W21438990762016 @default.
• W2143899076 countsByYear W21438990762017 @default.
• W2143899076 countsByYear W21438990762018 @default.
• W2143899076 countsByYear W21438990762019 @default.
• W2143899076 countsByYear W21438990762020 @default.
• W2143899076 countsByYear W21438990762021 @default.
• W2143899076 countsByYear W21438990762022 @default.
• W2143899076 countsByYear W21438990762023 @default.
• W2143899076 crossrefType "journal-article" @default.
• W2143899076 hasAuthorship W2143899076A5001917541 @default.
• W2143899076 hasAuthorship W2143899076A5028767906 @default.
• W2143899076 hasAuthorship W2143899076A5039216989 @default.
• W2143899076 hasAuthorship W2143899076A5040560862 @default.
• W2143899076 hasAuthorship W2143899076A5046511241 @default.
• W2143899076 hasAuthorship W2143899076A5049513875 @default.
• W2143899076 hasBestOaLocation W21438990761 @default.
• W2143899076 hasConcept C121608353 @default.
• W2143899076 hasConcept C134018914 @default.
• W2143899076 hasConcept C161879069 @default.
• W2143899076 hasConcept C2778608917 @default.
• W2143899076 hasConcept C2780394083 @default.
• W2143899076 hasConcept C502942594 @default.
• W2143899076 hasConcept C530470458 @default.
• W2143899076 hasConcept C54355233 @default.
• W2143899076 hasConcept C62478195 @default.
• W2143899076 hasConcept C65114990 @default.
• W2143899076 hasConcept C84606932 @default.
• W2143899076 hasConcept C86803240 @default.
• W2143899076 hasConcept C95444343 @default.

• next