FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143946875> ?p ?o ?g. }

• W2143946875 endingPage "3237" @default.
• W2143946875 startingPage "3233" @default.
• W2143946875 abstract "The present study aimed to investigate the effects of blocking nuclear factor (NF)-κB and/or extracellular signal-regulated kinase (ERK) signaling pathways on proliferation and apoptosis of melanoma cells in vitro. A375 Human melanoma cells were treated with U0126 (ERK signaling pathway inhibitor) and BMS-345541 (NF-κB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and Bcl-2 protein content was determined by western blot analysis. BMS-345541 and U0126 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41±1.38% for BMS-345541 alone, 30.64±2.86% for U0126 alone, and 77.27±2.70% for BMS-345541 and U0126 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with BMS-345541, U0126, and BMS-345541 and U0126 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98±1.03% in the BMS-345541 group, 13.96±0.96% in the U0126 group and 38.91±1.46% in the combination group; all significantly increased compared with the control group (P<0.01). Bcl-2 protein content in A375 cells was significantly increased following treatment with BMS-345541 and U0126, alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-κB and ERK signaling pathway inhibitors may serve as potential therapeutic targets for melanoma." @default.
• W2143946875 created "2016-06-24" @default.
• W2143946875 creator A5018889780 @default.
• W2143946875 creator A5019172340 @default.
• W2143946875 creator A5037240976 @default.
• W2143946875 creator A5053034522 @default.
• W2143946875 creator A5054767778 @default.
• W2143946875 date "2015-09-03" @default.
• W2143946875 modified "2023-09-25" @default.
• W2143946875 title "Effects of nuclear factor-κB and ERK signaling transduction pathway inhibitors on human melanoma cell proliferation in vitro" @default.
• W2143946875 cites W1572483109 @default.
• W2143946875 cites W1803959510 @default.
• W2143946875 cites W1952779226 @default.
• W2143946875 cites W1964445245 @default.
• W2143946875 cites W1965480120 @default.
• W2143946875 cites W1987328311 @default.
• W2143946875 cites W1991959249 @default.
• W2143946875 cites W2009637980 @default.
• W2143946875 cites W2018711510 @default.
• W2143946875 cites W2021309474 @default.
• W2143946875 cites W2037723110 @default.
• W2143946875 cites W2042513120 @default.
• W2143946875 cites W2066137841 @default.
• W2143946875 cites W2067276223 @default.
• W2143946875 cites W2086707191 @default.
• W2143946875 cites W2086778602 @default.
• W2143946875 cites W2088876286 @default.
• W2143946875 cites W2095217092 @default.
• W2143946875 cites W2100370559 @default.
• W2143946875 cites W2103027896 @default.
• W2143946875 cites W2123611729 @default.
• W2143946875 cites W2134167837 @default.
• W2143946875 cites W2157364557 @default.
• W2143946875 cites W2158036992 @default.
• W2143946875 cites W224323360 @default.
• W2143946875 doi "https://doi.org/10.3892/ol.2015.3672" @default.
• W2143946875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4665854" @default.
• W2143946875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26722318" @default.
• W2143946875 hasPublicationYear "2015" @default.
• W2143946875 type Work @default.
• W2143946875 sameAs 2143946875 @default.
• W2143946875 citedByCount "4" @default.
• W2143946875 countsByYear W21439468752016 @default.
• W2143946875 countsByYear W21439468752019 @default.
• W2143946875 countsByYear W21439468752020 @default.
• W2143946875 countsByYear W21439468752022 @default.
• W2143946875 crossrefType "journal-article" @default.
• W2143946875 hasAuthorship W2143946875A5018889780 @default.
• W2143946875 hasAuthorship W2143946875A5019172340 @default.
• W2143946875 hasAuthorship W2143946875A5037240976 @default.
• W2143946875 hasAuthorship W2143946875A5053034522 @default.
• W2143946875 hasAuthorship W2143946875A5054767778 @default.
• W2143946875 hasBestOaLocation W21439468752 @default.
• W2143946875 hasConcept C153911025 @default.
• W2143946875 hasConcept C184235292 @default.
• W2143946875 hasConcept C185592680 @default.
• W2143946875 hasConcept C190283241 @default.
• W2143946875 hasConcept C2781018059 @default.
• W2143946875 hasConcept C29537977 @default.
• W2143946875 hasConcept C502942594 @default.
• W2143946875 hasConcept C53227056 @default.
• W2143946875 hasConcept C55493867 @default.
• W2143946875 hasConcept C57074206 @default.
• W2143946875 hasConcept C62112901 @default.
• W2143946875 hasConcept C62478195 @default.
• W2143946875 hasConcept C71924100 @default.
• W2143946875 hasConcept C86803240 @default.
• W2143946875 hasConcept C95444343 @default.
• W2143946875 hasConcept C98274493 @default.
• W2143946875 hasConceptScore W2143946875C153911025 @default.
• W2143946875 hasConceptScore W2143946875C184235292 @default.
• W2143946875 hasConceptScore W2143946875C185592680 @default.
• W2143946875 hasConceptScore W2143946875C190283241 @default.
• W2143946875 hasConceptScore W2143946875C2781018059 @default.
• W2143946875 hasConceptScore W2143946875C29537977 @default.
• W2143946875 hasConceptScore W2143946875C502942594 @default.
• W2143946875 hasConceptScore W2143946875C53227056 @default.
• W2143946875 hasConceptScore W2143946875C55493867 @default.
• W2143946875 hasConceptScore W2143946875C57074206 @default.
• W2143946875 hasConceptScore W2143946875C62112901 @default.
• W2143946875 hasConceptScore W2143946875C62478195 @default.
• W2143946875 hasConceptScore W2143946875C71924100 @default.
• W2143946875 hasConceptScore W2143946875C86803240 @default.
• W2143946875 hasConceptScore W2143946875C95444343 @default.
• W2143946875 hasConceptScore W2143946875C98274493 @default.
• W2143946875 hasIssue "5" @default.
• W2143946875 hasLocation W21439468751 @default.
• W2143946875 hasLocation W21439468752 @default.
• W2143946875 hasLocation W21439468753 @default.
• W2143946875 hasLocation W21439468754 @default.
• W2143946875 hasOpenAccess W2143946875 @default.
• W2143946875 hasPrimaryLocation W21439468751 @default.
• W2143946875 hasRelatedWork W2023126270 @default.
• W2143946875 hasRelatedWork W2340428416 @default.
• W2143946875 hasRelatedWork W2348417465 @default.
• W2143946875 hasRelatedWork W2376964596 @default.
• W2143946875 hasRelatedWork W2387887448 @default.
• W2143946875 hasRelatedWork W2410520497 @default.

• next