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- W2143955128 abstract "Caffeine is thought to affect excitation-contraction coupling in cardiac muscle by activating the sarcoplasmic reticulum (SR) Ca2+-release channel. The effect of caffeine at the single channel level was studied by incorporating canine cardiac SR vesicles into planar lipid bilayers. Cardiac Ca2+-release channels were activated in a steady-state manner by millimolar cis-caffeine and displayed a unitary conductance (77 pS in 50 mM Ca2+ trans) similar to that previously observed for the Ca2+-activated cardiac channel. The caffeine-activated channel was moderately sensitive to the voltage applied across the bilayer, was sensitive to further activation by ATP, and was inhibited by Mg2+ and ruthenium red. Kinetic analysis showed that at low Ca2+ concentration, caffeine activated the channel by increasing the frequency and the duration of open events." @default.
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- W2143955128 date "1989-02-01" @default.
- W2143955128 modified "2023-09-27" @default.
- W2143955128 title "Single cardiac sarcoplasmic reticulum Ca2+-release channel: activation by caffeine" @default.
- W2143955128 doi "https://doi.org/10.1152/ajpheart.1989.256.2.h328" @default.
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