FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2143970281> ?p ?o ?g. }

• W2143970281 endingPage "1597" @default.
• W2143970281 startingPage "1587" @default.
• W2143970281 abstract "Upstream stimulatory factor 1 (USF 1), is a transcription factor controlling expression of several genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type 2 diabetes on chromosome 1q22-23. We sequenced USF1 in 24 UK FCHL probands, but found no rare or common cSNPs. Three common intronic single nucleotide ploymorphisms (SNP), 306A>G, 475C>T and 1748C>T, were identified and their association was examined with fasting and postprandial lipids and after an oral glucose tolerance test (OGTT) in the European Atherosclerosis Research Study II offspring study. There were no significant differences in allelic frequencies of the SNPs between cases and controls. Individually none of the SNPs showed significant associations with any parameter. In haplotype analysis, compared with other haplotypes, 475C/1748T showed significantly higher and 475T/1748T showed lower peak glucose (P=0.004 and 0.07, respectively) during the OGTT. There was significant case-control heterogeneity in the interaction of genotype with body mass index, on fasting low density lipoprotein with 306A>G and 1748C>T, and on borderline significance with fasting glucose with 475C>T (P=0.002, 0.0007 and 0.015, respectively). Furthermore, 475C>T showed interaction with both HSL-60C>G (case-control heterogeneity P=0.0002) on AUC TG and APOC3 -482C>T on plasma apoE levels (P=0.0012). Thus, in these healthy young men, variation in USF1 was the influencing feature of both glucose and lipid homeostasis showing case-control heterogeneity." @default.
• W2143970281 created "2016-06-24" @default.
• W2143970281 creator A5007875460 @default.
• W2143970281 creator A5019939363 @default.
• W2143970281 creator A5021254466 @default.
• W2143970281 creator A5030608525 @default.
• W2143970281 creator A5058425010 @default.
• W2143970281 creator A5064235722 @default.
• W2143970281 creator A5074465771 @default.
• W2143970281 creator A5078336145 @default.
• W2143970281 date "2004-06-02" @default.
• W2143970281 modified "2023-10-17" @default.
• W2143970281 title "Variation in USF1 shows haplotype effects, gene : gene and gene : environment associations with glucose and lipid parameters in the European Atherosclerosis Research Study II" @default.
• W2143970281 cites W1863562568 @default.
• W2143970281 cites W1971185974 @default.
• W2143970281 cites W1973754795 @default.
• W2143970281 cites W1975494488 @default.
• W2143970281 cites W1976717707 @default.
• W2143970281 cites W1984486655 @default.
• W2143970281 cites W1988205944 @default.
• W2143970281 cites W1990043097 @default.
• W2143970281 cites W2002345850 @default.
• W2143970281 cites W2008276973 @default.
• W2143970281 cites W2008363902 @default.
• W2143970281 cites W2013001651 @default.
• W2143970281 cites W2023329576 @default.
• W2143970281 cites W2034574098 @default.
• W2143970281 cites W2035126508 @default.
• W2143970281 cites W2037421625 @default.
• W2143970281 cites W2045384225 @default.
• W2143970281 cites W2046868406 @default.
• W2143970281 cites W2053452972 @default.
• W2143970281 cites W2066572517 @default.
• W2143970281 cites W2070445328 @default.
• W2143970281 cites W2074998760 @default.
• W2143970281 cites W2077991668 @default.
• W2143970281 cites W2079181092 @default.
• W2143970281 cites W2086947816 @default.
• W2143970281 cites W2100812380 @default.
• W2143970281 cites W2108150427 @default.
• W2143970281 cites W2123782138 @default.
• W2143970281 cites W2127958304 @default.
• W2143970281 cites W2129741326 @default.
• W2143970281 cites W2132198142 @default.
• W2143970281 cites W2142802148 @default.
• W2143970281 cites W2154730509 @default.
• W2143970281 cites W2155303688 @default.
• W2143970281 cites W2157712434 @default.
• W2143970281 cites W2160623613 @default.
• W2143970281 cites W2160942744 @default.
• W2143970281 cites W2164468903 @default.
• W2143970281 cites W2165896010 @default.
• W2143970281 cites W2404506793 @default.
• W2143970281 cites W4236974090 @default.
• W2143970281 cites W4240231573 @default.
• W2143970281 cites W93588716 @default.
• W2143970281 doi "https://doi.org/10.1093/hmg/ddh168" @default.
• W2143970281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15175273" @default.
• W2143970281 hasPublicationYear "2004" @default.
• W2143970281 type Work @default.
• W2143970281 sameAs 2143970281 @default.
• W2143970281 citedByCount "83" @default.
• W2143970281 countsByYear W21439702812012 @default.
• W2143970281 countsByYear W21439702812013 @default.
• W2143970281 countsByYear W21439702812014 @default.
• W2143970281 countsByYear W21439702812015 @default.
• W2143970281 countsByYear W21439702812016 @default.
• W2143970281 countsByYear W21439702812018 @default.
• W2143970281 countsByYear W21439702812019 @default.
• W2143970281 countsByYear W21439702812021 @default.
• W2143970281 countsByYear W21439702812023 @default.
• W2143970281 crossrefType "journal-article" @default.
• W2143970281 hasAuthorship W2143970281A5007875460 @default.
• W2143970281 hasAuthorship W2143970281A5019939363 @default.
• W2143970281 hasAuthorship W2143970281A5021254466 @default.
• W2143970281 hasAuthorship W2143970281A5030608525 @default.
• W2143970281 hasAuthorship W2143970281A5058425010 @default.
• W2143970281 hasAuthorship W2143970281A5064235722 @default.
• W2143970281 hasAuthorship W2143970281A5074465771 @default.
• W2143970281 hasAuthorship W2143970281A5078336145 @default.
• W2143970281 hasBestOaLocation W21439702811 @default.
• W2143970281 hasConcept C104317684 @default.
• W2143970281 hasConcept C126322002 @default.
• W2143970281 hasConcept C134018914 @default.
• W2143970281 hasConcept C135763542 @default.
• W2143970281 hasConcept C139275648 @default.
• W2143970281 hasConcept C153209595 @default.
• W2143970281 hasConcept C197754878 @default.
• W2143970281 hasConcept C2777180221 @default.
• W2143970281 hasConcept C2777391703 @default.
• W2143970281 hasConcept C2778199505 @default.
• W2143970281 hasConcept C3018667095 @default.
• W2143970281 hasConcept C54355233 @default.
• W2143970281 hasConcept C555293320 @default.
• W2143970281 hasConcept C71924100 @default.
• W2143970281 hasConcept C86803240 @default.
• W2143970281 hasConceptScore W2143970281C104317684 @default.
• W2143970281 hasConceptScore W2143970281C126322002 @default.

• next