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• W2143973670 abstract "Background Depressive disorders are common in young people and are associated with significant negative impacts. Newer generation antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs), are often used, however evidence of their effectiveness in children and adolescents is not clear. Furthermore, there have been warnings against their use in this population due to concerns about increased risk of suicidal ideation and behaviour. Objectives To determine the efficacy and adverse outcomes, including definitive suicidal behaviour and suicidal ideation, of newer generation antidepressants compared with placebo in the treatment of depressive disorders in children and adolescents. Search methods For this update of the review, we searched the Cochrane Depression, Anxiety and Neurosis Review Group's Specialised Register (CCDANCTR) to October 2011. The CCDANCTR includes relevant randomised controlled trials from the following bibliographic databases: CENTRAL (the Cochrane Central Register of Controlled Trials) (all years), EMBASE (1974 ‐), MEDLINE (1950 ‐) and PsycINFO (1967 ‐). We searched clinical trial registries and pharmaceutical company websites. We checked reference lists of included trials and other reviews, and sent letters to key researchers and the pharmaceutical companies of included trials from January to August 2011. Selection criteria Published and unpublished randomised controlled trials (RCTs), cross‐over trials and cluster trials comparing a newer generation antidepressant with a placebo in children and adolescents aged 6 to 18 years old and diagnosed with a depressive disorder were eligible for inclusion. In this update, we amended the selection criteria to include newer generation antidepressants rather than SSRIs only. Data collection and analysis Two or three review authors selected the trials, assessed their quality, and extracted trial and outcome data. We used a random‐effects meta‐analysis. We used risk ratio (RR) to summarise dichotomous outcomes and mean difference (MD) to summarise continuous measures. Main results Nineteen trials of a range of newer antidepressants compared with placebo, containing 3335 participants, were included. The trials excluded young people at high risk of suicide and many co‐morbid conditions and the participants are likely to be less unwell than those seen in clinical practice. We judged none of these trials to be at low risk of bias, with limited information about many aspects of risk of bias, high drop out rates and issues regarding measurement instruments and the clinical usefulness of outcomes, which were often variously defined across trials. Overall, there was evidence that those treated with an antidepressant had lower depression severity scores and higher rates of response/remission than those on placebo. However, the size of these effects was small with a reduction in depression symptoms of 3.51 on a scale from 17 to 113 (14 trials; N = 2490; MD ‐3.51; 95% confidence interval (CI) ‐4.55 to ‐2.47). Remission rates increased from 380 per 1000 to 448 per 1000 for those treated with an antidepressant. There was evidence of an increased risk (58%) of suicide‐related outcome for those on antidepressants compared with a placebo (17 trials; N = 3229; RR 1.58; 95% CI 1.02 to 2.45). This equates to an increased risk in a group with a median baseline risk from 25 in 1000 to 40 in 1000. Where rates of adverse events were reported, this was higher for those prescribed an antidepressant. There was no evidence that the magnitude of intervention effects (compared with placebo) were modified by individual drug class. Authors' conclusions Caution is required in interpreting the results given the methodological limitations of the included trials in terms of internal and external validity. Further, the size and clinical meaningfulness of statistically significant results are uncertain. However, given the risks of untreated depression in terms of completed suicide and impacts on functioning, if a decision to use medication is agreed, then fluoxetine might be the medication of first choice given guideline recommendations. Clinicians need to keep in mind that there is evidence of an increased risk of suicide‐related outcomes in those treated with antidepressant medications." @default.
• W2143973670 created "2016-06-24" @default.
• W2143973670 creator A5015844348 @default.
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• W2143973670 date "2012-11-14" @default.
• W2143973670 modified "2023-10-18" @default.
• W2143973670 title "Newer generation antidepressants for depressive disorders in children and adolescents" @default.
• W2143973670 cites W1215075678 @default.
• W2143973670 cites W1219424976 @default.
• W2143973670 cites W1498649466 @default.
• W2143973670 cites W1508951126 @default.
• W2143973670 cites W1516838546 @default.
• W2143973670 cites W1520036360 @default.
• W2143973670 cites W1540256881 @default.
• W2143973670 cites W1566635326 @default.
• W2143973670 cites W1592653824 @default.
• W2143973670 cites W1598602811 @default.
• W2143973670 cites W1736508677 @default.
• W2143973670 cites W1839280266 @default.
• W2143973670 cites W1868235462 @default.
• W2143973670 cites W1868973324 @default.
• W2143973670 cites W1904816587 @default.
• W2143973670 cites W1935785240 @default.
• W2143973670 cites W1963602813 @default.
• W2143973670 cites W1963712950 @default.
• W2143973670 cites W1968094206 @default.
• W2143973670 cites W1969298821 @default.
• W2143973670 cites W1970440127 @default.
• W2143973670 cites W1971572368 @default.
• W2143973670 cites W1972489980 @default.
• W2143973670 cites W1974273367 @default.
• W2143973670 cites W1977866915 @default.
• W2143973670 cites W1978667014 @default.
• W2143973670 cites W1979796529 @default.
• W2143973670 cites W1983244111 @default.
• W2143973670 cites W1984052453 @default.
• W2143973670 cites W1984249564 @default.
• W2143973670 cites W1985237413 @default.
• W2143973670 cites W1987445108 @default.
• W2143973670 cites W1991056345 @default.
• W2143973670 cites W1991536770 @default.
• W2143973670 cites W1993085080 @default.
• W2143973670 cites W1994816237 @default.
• W2143973670 cites W1994910887 @default.
• W2143973670 cites W1996184629 @default.
• W2143973670 cites W1997645413 @default.
• W2143973670 cites W1998149933 @default.
• W2143973670 cites W2000931689 @default.
• W2143973670 cites W2001006634 @default.
• W2143973670 cites W2001735507 @default.
• W2143973670 cites W2002633232 @default.
• W2143973670 cites W2002852004 @default.
• W2143973670 cites W2003027810 @default.
• W2143973670 cites W2004078469 @default.
• W2143973670 cites W2004288616 @default.
• W2143973670 cites W2005759468 @default.
• W2143973670 cites W2005900887 @default.
• W2143973670 cites W2007068998 @default.
• W2143973670 cites W2007328738 @default.
• W2143973670 cites W2007759334 @default.
• W2143973670 cites W2008578843 @default.
• W2143973670 cites W2008693468 @default.
• W2143973670 cites W2013337297 @default.
• W2143973670 cites W2013933708 @default.
• W2143973670 cites W2014644708 @default.
• W2143973670 cites W2015709747 @default.
• W2143973670 cites W2016667558 @default.
• W2143973670 cites W2026828867 @default.
• W2143973670 cites W2030488846 @default.
• W2143973670 cites W2032541700 @default.
• W2143973670 cites W2035277845 @default.
• W2143973670 cites W2038806907 @default.
• W2143973670 cites W2039418122 @default.
• W2143973670 cites W2040053981 @default.
• W2143973670 cites W2041273044 @default.
• W2143973670 cites W2045896666 @default.
• W2143973670 cites W2046264373 @default.
• W2143973670 cites W2046787764 @default.
• W2143973670 cites W2048117306 @default.
• W2143973670 cites W2049618851 @default.
• W2143973670 cites W2052183675 @default.
• W2143973670 cites W2053676871 @default.
• W2143973670 cites W2053767485 @default.
• W2143973670 cites W2054206271 @default.
• W2143973670 cites W2056273564 @default.
• W2143973670 cites W2056788294 @default.
• W2143973670 cites W2060559501 @default.
• W2143973670 cites W2065657098 @default.
• W2143973670 cites W2065974896 @default.
• W2143973670 cites W2067495470 @default.
• W2143973670 cites W2067632420 @default.
• W2143973670 cites W2068211542 @default.
• W2143973670 cites W2068681332 @default.
• W2143973670 cites W2074020937 @default.
• W2143973670 cites W2075049994 @default.
• W2143973670 cites W2075247345 @default.
• W2143973670 cites W2075766739 @default.

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