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• W2143977369 abstract "It has been known for sometime that thrombopoietin acts on megakaryocytic progenitor cells to stimulate platelet production. It has recently been discovered that it also stimulates the self-renewal and expansion of normal murine and human haematopoietic stem cells (HSCs) by acting on its cognate receptor, the product of the myeloproliferative leukaemia (c-MPL) proto-oncogene. The c-MPL receptor may also play an important role in the development of human myeloproliferative disorders, essential thrombocythemia, myelofibrosis and polycythemia vera, cooperating with the dysregulated Janus kinase JAK2V617F." @default.
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• W2143977369 date "2009-12-01" @default.
• W2143977369 modified "2023-09-24" @default.
• W2143977369 title "Thrombopoietin in normal and neoplastic stem cell development" @default.
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• W2143977369 doi "https://doi.org/10.1016/j.beha.2009.08.004" @default.
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