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• W2143989957 startingPage "141" @default.
• W2143989957 abstract "Despite many decades of research, the reasons why only a relatively small proportion of individuals who consume excessive quantities of alcohol develop clinically significant liver disease remain unknown. The association with features of autoimmune diseases, including hypergammaglobulinaemia, circulating autoantibodies, inheritance of certain immunogenetic (HLA) markers and response to corticosteroid therapy in some patients has led to a persistent impression that altered immune regulation with a relative loss of self-tolerance underlies susceptibility to the development of the more severe forms of alcoholic liver disease (alcoholic hepatitis and/or cirrhosis). However, review of the data from the numerous studies that have been conducted over the past 30 years fails to reveal sufficiently convincing evidence that autoimmunity plays a primary role in alcohol-related liver damage. In particular, most of the wide range of circulating autoantibodies that have been reported in patients are found mainly at low titres, are not confined to those with severe liver injury, and are probably more likely to be a response to the hepatic insult than causally related to liver damage. Additionally, an association with various HLA phenotypes has not been confirmed by meta-analysis. Interpretation is complicated by evidence that alcohol may have direct effects on some components of the immune system but, if there is an immunogenetic basis for alcoholic liver disease, the present evidence suggests that this might be related more to cytokine gene polymorphisms than to a predisposition to autoimmunity per se." @default.
• W2143989957 created "2016-06-24" @default.
• W2143989957 creator A5022401547 @default.
• W2143989957 date "2000-04-01" @default.
• W2143989957 modified "2023-10-16" @default.
• W2143989957 title "Autoantibodies in alcoholic liver disease" @default.
• W2143989957 cites W1425488162 @default.
• W2143989957 cites W1597929292 @default.
• W2143989957 cites W1934611678 @default.
• W2143989957 cites W1968137318 @default.
• W2143989957 cites W1972706775 @default.
• W2143989957 cites W1972798426 @default.
• W2143989957 cites W1974737594 @default.
• W2143989957 cites W1974753768 @default.
• W2143989957 cites W1975058568 @default.
• W2143989957 cites W1979454312 @default.
• W2143989957 cites W1984599257 @default.
• W2143989957 cites W1990413063 @default.
• W2143989957 cites W1994932951 @default.
• W2143989957 cites W1997622569 @default.
• W2143989957 cites W2000314587 @default.
• W2143989957 cites W2003238954 @default.
• W2143989957 cites W2004200672 @default.
• W2143989957 cites W2004286600 @default.
• W2143989957 cites W2006848760 @default.
• W2143989957 cites W2008649252 @default.
• W2143989957 cites W2010643478 @default.
• W2143989957 cites W2013632260 @default.
• W2143989957 cites W2014758403 @default.
• W2143989957 cites W2014881201 @default.
• W2143989957 cites W2015343906 @default.
• W2143989957 cites W2020830101 @default.
• W2143989957 cites W2023544956 @default.
• W2143989957 cites W2024541597 @default.
• W2143989957 cites W2031178654 @default.
• W2143989957 cites W2031688967 @default.
• W2143989957 cites W2040078568 @default.
• W2143989957 cites W2041686217 @default.
• W2143989957 cites W2044585955 @default.
• W2143989957 cites W2044720356 @default.
• W2143989957 cites W2048737273 @default.
• W2143989957 cites W2057594695 @default.
• W2143989957 cites W2057641970 @default.
• W2143989957 cites W2060834775 @default.
• W2143989957 cites W2063414191 @default.
• W2143989957 cites W2063924895 @default.
• W2143989957 cites W2064188549 @default.
• W2143989957 cites W2065157394 @default.
• W2143989957 cites W2066164212 @default.
• W2143989957 cites W2070490665 @default.
• W2143989957 cites W2073723779 @default.
• W2143989957 cites W2073854004 @default.
• W2143989957 cites W2073886527 @default.
• W2143989957 cites W2075379439 @default.
• W2143989957 cites W2075526365 @default.
• W2143989957 cites W2076594178 @default.
• W2143989957 cites W2078144327 @default.
• W2143989957 cites W2078955844 @default.
• W2143989957 cites W2080277464 @default.
• W2143989957 cites W2081989384 @default.
• W2143989957 cites W2092483753 @default.
• W2143989957 cites W2092810383 @default.
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• W2143989957 cites W2108028209 @default.
• W2143989957 cites W2111528062 @default.
• W2143989957 cites W2114918842 @default.
• W2143989957 cites W2117970905 @default.
• W2143989957 cites W2119515381 @default.
• W2143989957 cites W2121913685 @default.
• W2143989957 cites W2125942737 @default.
• W2143989957 cites W2134193741 @default.
• W2143989957 cites W2136800150 @default.
• W2143989957 cites W2137054468 @default.
• W2143989957 cites W2139825247 @default.
• W2143989957 cites W2146576023 @default.
• W2143989957 cites W2154230025 @default.
• W2143989957 cites W2155674048 @default.
• W2143989957 cites W2163448632 @default.
• W2143989957 cites W2170705556 @default.
• W2143989957 cites W2180226000 @default.
• W2143989957 cites W2181398244 @default.
• W2143989957 cites W2329053149 @default.
• W2143989957 cites W2329563581 @default.
• W2143989957 cites W2403678579 @default.
• W2143989957 cites W2414855126 @default.
• W2143989957 cites W2440252934 @default.
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• W2143989957 doi "https://doi.org/10.1080/13556210050003720" @default.
• W2143989957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20575828" @default.
• W2143989957 hasPublicationYear "2000" @default.
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