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• W2143999360 abstract "The toxicity of green tea extract (GTE) was evaluated in 14-week gavage studies in male and female F344/NTac rats and B6C3F1 mice at doses up to 1,000 mg/kg. In the rats, no treatment-related mortality was noted. In the mice, treatment-related mortality occurred in male and female mice in the 1,000 mg/kg dose groups. The cause of early deaths was likely related to liver necrosis. Treatment-related histopathological changes were seen in both species in the liver, nose, mesenteric lymph nodes, and thymus. In addition, in mice, changes were seen in the Peyer’s patches, spleen, and mandibular lymph nodes. The no adverse effect level (NOAEL) for the liver in both species was 500 mg/kg. In the nose of rats, the NOAEL in males was 62.5 mg/kg, and in females no NOAEL was found. No NOAEL was found in the nose of female or male mice. The changes in the liver and nose were considered primary toxic effects of GTE, while the changes in other organs were considered to be secondary effects. The nose and liver are organs with high metabolic enzyme activity. The increased susceptibility of the nose and liver suggests a role for GTE metabolites in toxicity induction." @default.
• W2143999360 created "2016-06-24" @default.
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• W2143999360 date "2010-09-30" @default.
• W2143999360 modified "2023-10-17" @default.
• W2143999360 title "Fourteen-Week Toxicity Study of Green Tea Extract in Rats and Mice" @default.
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• W2143999360 doi "https://doi.org/10.1177/0192623310382437" @default.
• W2143999360 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3175604" @default.
• W2143999360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20884815" @default.
• W2143999360 hasPublicationYear "2010" @default.
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