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- W2144014710 abstract "To the Editor: Vesprini et al ( 1 Vesprini D. Catton C. Jacks L. et al. Inverse relationship between biochemical outcome and acute toxicity after image-guided radiotherapy for prostate cancer. Int J Radiat Oncol Biol Phys. 2012; 83: 608-616 PubMed Scopus (7) Google Scholar ) recently analyzed biochemical failure-free rate (BFFR; American Society for Radiation Oncology definition) and acute toxicity in 362 patients with localized prostate cancer treated with image guided radiation therapy. At 5 years, 76% of patients who reported acute toxicity scores <2 were failure free. In contrast, only 53% of those who reported worse acute toxicity (defined as “sensitive” by the authors) were failure free. Comparable findings were reported when using the Phoenix definition of BFFR. Maybe we should borrow the term “double trouble” to describe this inverse relationship? The difference remained significant when controlled for radiation dose, prognostic stratification, and prostate volume. The authors discussed potential explanations (of note, this was a retrospective study, and unknown confounders might have influenced the results), but several important and different hypotheses not included in the article should also be considered. Inverse Relationship Between Biochemical Outcome and Acute Toxicity After Image-Guided Radiotherapy for Prostate CancerInternational Journal of Radiation Oncology, Biology, PhysicsVol. 83Issue 2PreviewProstate cancer patients exhibit variability in normal tissue reactions and biochemical failure. With the use of image-guided radiotherapy (IGRT), there is a greater likelihood that the differences in normal tissue and tumor response are due to biological rather than physical factors. We tested the hypothesis that prospectively scored acute toxicity is associated with biochemical failure-free rate (BFFR) in prostate cancer patients treated with IGRT. Full-Text PDF In Reply to NiederInternational Journal of Radiation Oncology, Biology, PhysicsVol. 85Issue 3PreviewTo the Editor: We thank Nieder for his thoughtful comments on our recent article (1, 2) that showed an inverse relationship between acute toxicity and biochemical control in prostate cancer patients treated with radical radiation therapy. Full-Text PDF" @default.
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- W2144014710 date "2013-03-01" @default.
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- W2144014710 title "In Regard to Vesprini et al" @default.
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- W2144014710 doi "https://doi.org/10.1016/j.ijrobp.2012.08.009" @default.
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