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- W2144032008 abstract "As a treatment for ectopic pregnancy or for excision of hydrosalpinx, salpingectomy is a relatively common procedure performed on patients undergoing assisted reproductive technology (ART). However, shared vasculature in the mesosalpinx raises the question of ovarian devitalization at time of surgery. The effect of salpingectomy on ovarian reserve is not well understood and presents a unique concern in women with already diminished reserve. The objective of this study is to ascertain the impact of salpingectomy on the future fertility of women undergoing ART by evaluating ovarian reserve and ovarian responsiveness in the ART cycle following unilateral or bilateral salpingectomy for the treatment of ectopic pregnancy or hydrosalpinx. A systematic review was performed by searching PubMed, Embase, Scopus, and CENTRAL for studies that compared markers of ovarian reserve and measures of ovarian responsiveness during ART before and after salpingectomy for the treatment of ectopic pregnancy or hydrosalpinx. With IRB approval, primary data from our institution was pooled in the final analysis. Meta-analysis of the data was performed using a DerSimonion-Laird random effects model. Results are reported as weighted mean difference and 95% confidence interval. Eight studies and our center's primary data were included, totaling 274 women. No differences were noted comparing pre-salpingectomy IVF cycles to post-salpingectomy cycles in regards to ovarian reserve parameters or ovarian response as assessed by stimulation duration, total dose of gonadotropins or peak estradiol levels. In addition, there were no differences in oocytes retrieved (Figure 1). A post-hoc power analysis determined that a study of this size would be able to detect an 8.3% difference in oocytes retrieved (1 oocyte) with 80% power. Our findings support the continued use of salpingectomy in the management of ectopic pregnancy and hydrosalpinges. Primary data is needed to stratify the analysis to determine if women of advanced age or diminished ovarian reserve are at a higher risk of effects from salpingectomy." @default.
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- W2144032008 date "2015-02-01" @default.
- W2144032008 modified "2023-09-29" @default.
- W2144032008 title "Effect of Salpingectomy on Ovarian Reserve: A Systematic Review and Meta-Analysis" @default.
- W2144032008 doi "https://doi.org/10.1016/j.fertnstert.2014.12.020" @default.
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