FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144041760> ?p ?o ?g. }

• W2144041760 endingPage "75" @default.
• W2144041760 startingPage "69" @default.
• W2144041760 abstract "A total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is considered the surgery of choice for definitive management of familial adenomatous polyposis (FAP) and some patients with ulcerative colitis (UC). However, this surgical treatment is often associated with pouchitis, a long-term complication that occurs mostly in UC patients. The purpose of this study was to better define the molecular background of pouchitis. A microarray-based survey was performed using pouch mucosal samples collected from 28 and 8 patients undergoing surgery for UC and FAP, respectively. There were 4,770 genes that significantly differentiated uninflamed from inflamed mucosal samples, and their functional features were represented mostly by metabolic and cell proliferation pathways. In contrast, functional analyses of aberrantly expressed genes between UC and FAP samples, irrespective of mucosal inflammation status, revealed multiple pathways and terms that were linked to changes in immune response. Interestingly, the comparison of uninflamed UC and FAP samples identified a set of 29 altered probe sets, including an inflammation-related transcript encoding a Charcot-Leyden crystal (CLC) protein. The most distinct changes in gene expression profiles differentiating uninflamed UC and FAP pouch mucosal samples were attributed to the Gene Ontology category innate immune response. Our study confirmed that alterations in immune responses can be found between patients who underwent surgery for UC and FAP, independent of the pouch inflammation status. This observation may be important when managing IPAA patients." @default.
• W2144041760 created "2016-06-24" @default.
• W2144041760 creator A5000571424 @default.
• W2144041760 creator A5007944267 @default.
• W2144041760 creator A5018447098 @default.
• W2144041760 creator A5024553730 @default.
• W2144041760 creator A5026668230 @default.
• W2144041760 creator A5060181038 @default.
• W2144041760 creator A5061008099 @default.
• W2144041760 creator A5063585167 @default.
• W2144041760 creator A5068308281 @default.
• W2144041760 date "2015-01-01" @default.
• W2144041760 modified "2023-10-17" @default.
• W2144041760 title "Transcriptional changes between uninflamed ulcerative colitis and familial adenomatous polyposis pouch mucosa can be attributed to an altered immune response" @default.
• W2144041760 cites W1509102678 @default.
• W2144041760 cites W1577060935 @default.
• W2144041760 cites W1577577364 @default.
• W2144041760 cites W1609503004 @default.
• W2144041760 cites W1964944881 @default.
• W2144041760 cites W1966167200 @default.
• W2144041760 cites W1976066326 @default.
• W2144041760 cites W1979948289 @default.
• W2144041760 cites W1997277773 @default.
• W2144041760 cites W2005588132 @default.
• W2144041760 cites W2028840333 @default.
• W2144041760 cites W2041278750 @default.
• W2144041760 cites W2057271458 @default.
• W2144041760 cites W2063512218 @default.
• W2144041760 cites W2067213652 @default.
• W2144041760 cites W2072799792 @default.
• W2144041760 cites W2083759302 @default.
• W2144041760 cites W2086382866 @default.
• W2144041760 cites W2088890582 @default.
• W2144041760 cites W2097189677 @default.
• W2144041760 cites W2103017472 @default.
• W2144041760 cites W2104194813 @default.
• W2144041760 cites W2106608030 @default.
• W2144041760 cites W2107277218 @default.
• W2144041760 cites W2118030557 @default.
• W2144041760 cites W2141320958 @default.
• W2144041760 cites W2149541458 @default.
• W2144041760 cites W2149943864 @default.
• W2144041760 cites W2160697532 @default.
• W2144041760 cites W2317635977 @default.
• W2144041760 cites W66356901 @default.
• W2144041760 doi "https://doi.org/10.18388/abp.2014_778" @default.
• W2144041760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25654358" @default.
• W2144041760 hasPublicationYear "2015" @default.
• W2144041760 type Work @default.
• W2144041760 sameAs 2144041760 @default.
• W2144041760 citedByCount "8" @default.
• W2144041760 countsByYear W21440417602016 @default.
• W2144041760 countsByYear W21440417602017 @default.
• W2144041760 countsByYear W21440417602019 @default.
• W2144041760 countsByYear W21440417602022 @default.
• W2144041760 countsByYear W21440417602023 @default.
• W2144041760 crossrefType "journal-article" @default.
• W2144041760 hasAuthorship W2144041760A5000571424 @default.
• W2144041760 hasAuthorship W2144041760A5007944267 @default.
• W2144041760 hasAuthorship W2144041760A5018447098 @default.
• W2144041760 hasAuthorship W2144041760A5024553730 @default.
• W2144041760 hasAuthorship W2144041760A5026668230 @default.
• W2144041760 hasAuthorship W2144041760A5060181038 @default.
• W2144041760 hasAuthorship W2144041760A5061008099 @default.
• W2144041760 hasAuthorship W2144041760A5063585167 @default.
• W2144041760 hasAuthorship W2144041760A5068308281 @default.
• W2144041760 hasBestOaLocation W21440417601 @default.
• W2144041760 hasConcept C104317684 @default.
• W2144041760 hasConcept C121608353 @default.
• W2144041760 hasConcept C126322002 @default.
• W2144041760 hasConcept C141071460 @default.
• W2144041760 hasConcept C150194340 @default.
• W2144041760 hasConcept C186836561 @default.
• W2144041760 hasConcept C203014093 @default.
• W2144041760 hasConcept C2775862500 @default.
• W2144041760 hasConcept C2776914184 @default.
• W2144041760 hasConcept C2777077811 @default.
• W2144041760 hasConcept C2778237340 @default.
• W2144041760 hasConcept C2779134260 @default.
• W2144041760 hasConcept C2779454807 @default.
• W2144041760 hasConcept C2780101441 @default.
• W2144041760 hasConcept C2780479503 @default.
• W2144041760 hasConcept C2780814781 @default.
• W2144041760 hasConcept C526805850 @default.
• W2144041760 hasConcept C54355233 @default.
• W2144041760 hasConcept C71924100 @default.
• W2144041760 hasConcept C8415881 @default.
• W2144041760 hasConcept C86803240 @default.
• W2144041760 hasConcept C8891405 @default.
• W2144041760 hasConcept C90924648 @default.
• W2144041760 hasConceptScore W2144041760C104317684 @default.
• W2144041760 hasConceptScore W2144041760C121608353 @default.
• W2144041760 hasConceptScore W2144041760C126322002 @default.
• W2144041760 hasConceptScore W2144041760C141071460 @default.
• W2144041760 hasConceptScore W2144041760C150194340 @default.
• W2144041760 hasConceptScore W2144041760C186836561 @default.
• W2144041760 hasConceptScore W2144041760C203014093 @default.
• W2144041760 hasConceptScore W2144041760C2775862500 @default.

• next