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- W2144050390 abstract "textabstractGastric Helicobacter species are adapted to colonize the acidic environment of the stomach.Colonization with H pylori is life long if untreated, and can lead to gastritis, peptic ulcerdisease and eventually to gastric cancer. Although H pylori is sensitive to many antibiotics invitro, only a limited number of antibiotics can be used in vivo while increasing resistanceagainst these therapeutics significantly impairs the treatment of H pylori infection.Metals play an essential role in the metabolism of all living organisms, including gastricHelicobacter species, but can also be deleterious when metal availability is either too low ortoo high. Therefore cells need to maintain homeostasis of intracellular metal concentrations toallow survival and growth. A better understanding of metal homeostasis in gastricHelicobacter species may allow for the knowledge-led development of therapeutics which arebased on disturbing the balance of the intracellular metal concentrations to either toxicity orrestriction. The focus of this PhD-thesis is on nickel metabolism, since this metal is thecofactor of the urease enzyme and hydrogenase enzyme, both essential for colonization ofgastric Helicobacter species. The high expression level of the urease enzyme mediates acidresistance in the presence of urea, but also necessitates the import of relatively highconcentrations of nickel. Although transcriptional regulation by the nickel-dependentregulator NikR has been studied, relative little is known about which proteins are involved inactual transport of nickel. The genome era has opened the possibility of functional genomicsinvestigations, using the information from the genomes of different Helicobacter species.Many of the genes of Helicobacter species do not yet have a predicted function, or have beenassigned a putative function only based on homology with genes from other bacterial species.Comparison of the genomic content of different Helicobacter species and transcriptional andfunctional characterization of the genes putatively involved in nickel homeostasis, aspresented in this thesis, will provide more insight in how these bacteria are able to acquiresufficient concentrations of nickel." @default.
- W2144050390 created "2016-06-24" @default.
- W2144050390 creator A5027956298 @default.
- W2144050390 date "2011-01-05" @default.
- W2144050390 modified "2023-09-24" @default.
- W2144050390 title "Nickel Homeostasis in Helicobacter Species" @default.
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