FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144052775> ?p ?o ?g. }

• W2144052775 endingPage "284" @default.
• W2144052775 startingPage "278" @default.
• W2144052775 abstract "DNA methylation at the fifth position of cytosine (5mC) is an important epigenetic modification that affects chromatin structure and gene expression. Recent studies have established a critical function of the Ten-eleven translocation (Tet) family of proteins in regulating DNA methylation dynamics. Three Tet genes have been identified in mammals, and they all encode for proteins capable of oxidizing 5mC as part of the DNA demethylation process. Although regulation of Tet expression at the transcriptional level is well documented, how TET proteins are regulated at posttranslational level is poorly understood. In this study, we report that all three TET proteins are direct substrates of calpains, a family of calcium-dependent proteases. Specifically, calpain1 mediates TET1 and TET2 turnover in mouse ESCs, and calpain2 regulates TET3 level during differentiation. This study provides evidence that TET proteins are subject to calpain-mediated degradation." @default.
• W2144052775 created "2016-06-24" @default.
• W2144052775 creator A5047043019 @default.
• W2144052775 creator A5079594267 @default.
• W2144052775 date "2014-01-01" @default.
• W2144052775 modified "2023-10-18" @default.
• W2144052775 title "Regulation of TET Protein Stability by Calpains" @default.
• W2144052775 cites W1942214720 @default.
• W2144052775 cites W1967111894 @default.
• W2144052775 cites W1970145665 @default.
• W2144052775 cites W1977846137 @default.
• W2144052775 cites W1978867062 @default.
• W2144052775 cites W1981463058 @default.
• W2144052775 cites W1997453048 @default.
• W2144052775 cites W2003171404 @default.
• W2144052775 cites W2008186920 @default.
• W2144052775 cites W2012701284 @default.
• W2144052775 cites W2014368894 @default.
• W2144052775 cites W2024551920 @default.
• W2144052775 cites W2036176224 @default.
• W2144052775 cites W2038062002 @default.
• W2144052775 cites W2038449573 @default.
• W2144052775 cites W2053930062 @default.
• W2144052775 cites W2060289910 @default.
• W2144052775 cites W2060849333 @default.
• W2144052775 cites W2063711843 @default.
• W2144052775 cites W2064815984 @default.
• W2144052775 cites W2068050716 @default.
• W2144052775 cites W2074822409 @default.
• W2144052775 cites W2080777953 @default.
• W2144052775 cites W2087367624 @default.
• W2144052775 cites W2095915414 @default.
• W2144052775 cites W2108664872 @default.
• W2144052775 cites W2138472595 @default.
• W2144052775 cites W2150123812 @default.
• W2144052775 cites W2151078743 @default.
• W2144052775 cites W2170039745 @default.
• W2144052775 doi "https://doi.org/10.1016/j.celrep.2013.12.031" @default.
• W2144052775 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4227594" @default.
• W2144052775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24412366" @default.
• W2144052775 hasPublicationYear "2014" @default.
• W2144052775 type Work @default.
• W2144052775 sameAs 2144052775 @default.
• W2144052775 citedByCount "87" @default.
• W2144052775 countsByYear W21440527752014 @default.
• W2144052775 countsByYear W21440527752015 @default.
• W2144052775 countsByYear W21440527752016 @default.
• W2144052775 countsByYear W21440527752017 @default.
• W2144052775 countsByYear W21440527752018 @default.
• W2144052775 countsByYear W21440527752019 @default.
• W2144052775 countsByYear W21440527752020 @default.
• W2144052775 countsByYear W21440527752021 @default.
• W2144052775 countsByYear W21440527752022 @default.
• W2144052775 countsByYear W21440527752023 @default.
• W2144052775 crossrefType "journal-article" @default.
• W2144052775 hasAuthorship W2144052775A5047043019 @default.
• W2144052775 hasAuthorship W2144052775A5079594267 @default.
• W2144052775 hasBestOaLocation W21440527751 @default.
• W2144052775 hasConcept C104317684 @default.
• W2144052775 hasConcept C150194340 @default.
• W2144052775 hasConcept C165864922 @default.
• W2144052775 hasConcept C16824249 @default.
• W2144052775 hasConcept C181199279 @default.
• W2144052775 hasConcept C182220744 @default.
• W2144052775 hasConcept C190727270 @default.
• W2144052775 hasConcept C41091548 @default.
• W2144052775 hasConcept C54355233 @default.
• W2144052775 hasConcept C552990157 @default.
• W2144052775 hasConcept C55493867 @default.
• W2144052775 hasConcept C64927066 @default.
• W2144052775 hasConcept C83640560 @default.
• W2144052775 hasConcept C86339819 @default.
• W2144052775 hasConcept C86803240 @default.
• W2144052775 hasConcept C94966510 @default.
• W2144052775 hasConcept C95444343 @default.
• W2144052775 hasConceptScore W2144052775C104317684 @default.
• W2144052775 hasConceptScore W2144052775C150194340 @default.
• W2144052775 hasConceptScore W2144052775C165864922 @default.
• W2144052775 hasConceptScore W2144052775C16824249 @default.
• W2144052775 hasConceptScore W2144052775C181199279 @default.
• W2144052775 hasConceptScore W2144052775C182220744 @default.
• W2144052775 hasConceptScore W2144052775C190727270 @default.
• W2144052775 hasConceptScore W2144052775C41091548 @default.
• W2144052775 hasConceptScore W2144052775C54355233 @default.
• W2144052775 hasConceptScore W2144052775C552990157 @default.
• W2144052775 hasConceptScore W2144052775C55493867 @default.
• W2144052775 hasConceptScore W2144052775C64927066 @default.
• W2144052775 hasConceptScore W2144052775C83640560 @default.
• W2144052775 hasConceptScore W2144052775C86339819 @default.
• W2144052775 hasConceptScore W2144052775C86803240 @default.
• W2144052775 hasConceptScore W2144052775C94966510 @default.
• W2144052775 hasConceptScore W2144052775C95444343 @default.
• W2144052775 hasIssue "2" @default.
• W2144052775 hasLocation W21440527751 @default.
• W2144052775 hasLocation W21440527752 @default.
• W2144052775 hasLocation W21440527753 @default.
• W2144052775 hasLocation W21440527754 @default.
• W2144052775 hasLocation W21440527755 @default.

• next