FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144054977> ?p ?o ?g. }

• W2144054977 endingPage "4045" @default.
• W2144054977 startingPage "4034" @default.
• W2144054977 abstract "ABSTRACT A hallmark of Yersinia pestis infection is a delayed inflammatory response early in infection. In this study, we use an intradermal model of infection to study early innate immune cell recruitment. Mice were injected intradermally in the ear with wild-type (WT) or attenuated Y. pestis lacking the pYV virulence plasmid (pYV − ). The inflammatory responses in ear and draining lymph node samples were evaluated by flow cytometry and immunohistochemistry. As measured by flow cytometry, total neutrophil and macrophage recruitment to the ear in WT-infected mice did not differ from phosphate-buffered saline (PBS) controls or mice infected with pYV − , except for a transient increase in macrophages at 6 h compared to the PBS control. Limited inflammation was apparent even in animals with high bacterial loads (10 5 to 10 6 CFU). In addition, activation of inflammatory cells was significantly reduced in WT-infected mice as measured by CD11b and major histocompatibility complex class II (MHC-II) expression. When mice infected with WT were injected 12 h later at the same intradermal site with purified LPS, Y. pestis did not prevent recruitment of neutrophils. However, significant reduction in neutrophil activation remained compared to that of PBS and pYV − controls. Immunohistochemistry revealed qualitative differences in neutrophil recruitment to the skin and draining lymph node, with WT-infected mice producing a diffuse inflammatory response. In contrast, focal sites of neutrophil recruitment were sustained through 48 h postinfection in pYV − -infected mice. Thus, an important feature of Y. pestis infection is reduced activation and organization of inflammatory cells that is at least partially dependent on the pYV virulence plasmid." @default.
• W2144054977 created "2016-06-24" @default.
• W2144054977 creator A5006099075 @default.
• W2144054977 creator A5016076855 @default.
• W2144054977 creator A5060699297 @default.
• W2144054977 creator A5065518781 @default.
• W2144054977 date "2012-11-01" @default.
• W2144054977 modified "2023-10-01" @default.
• W2144054977 title "Kinetics of Innate Immune Response to Yersinia pestis after Intradermal Infection in a Mouse Model" @default.
• W2144054977 cites W1511392731 @default.
• W2144054977 cites W1537283539 @default.
• W2144054977 cites W1947904991 @default.
• W2144054977 cites W1963810218 @default.
• W2144054977 cites W1965970815 @default.
• W2144054977 cites W1981225398 @default.
• W2144054977 cites W1982194149 @default.
• W2144054977 cites W1991518398 @default.
• W2144054977 cites W1996162233 @default.
• W2144054977 cites W1999561988 @default.
• W2144054977 cites W2004162848 @default.
• W2144054977 cites W2006045065 @default.
• W2144054977 cites W2007386503 @default.
• W2144054977 cites W2012636177 @default.
• W2144054977 cites W2018830354 @default.
• W2144054977 cites W2033787149 @default.
• W2144054977 cites W2047209258 @default.
• W2144054977 cites W2049281893 @default.
• W2144054977 cites W2072617582 @default.
• W2144054977 cites W2072805330 @default.
• W2144054977 cites W2087820683 @default.
• W2144054977 cites W2089249763 @default.
• W2144054977 cites W2095645811 @default.
• W2144054977 cites W2099893307 @default.
• W2144054977 cites W2103751544 @default.
• W2144054977 cites W2105029577 @default.
• W2144054977 cites W2106687873 @default.
• W2144054977 cites W2107156801 @default.
• W2144054977 cites W2109427912 @default.
• W2144054977 cites W2111275724 @default.
• W2144054977 cites W2118282630 @default.
• W2144054977 cites W2120412245 @default.
• W2144054977 cites W2120573126 @default.
• W2144054977 cites W2126147958 @default.
• W2144054977 cites W2127982761 @default.
• W2144054977 cites W2128537616 @default.
• W2144054977 cites W2131558932 @default.
• W2144054977 cites W2132032241 @default.
• W2144054977 cites W2132868108 @default.
• W2144054977 cites W2133319714 @default.
• W2144054977 cites W2136057472 @default.
• W2144054977 cites W2136070484 @default.
• W2144054977 cites W2145638464 @default.
• W2144054977 cites W2145912774 @default.
• W2144054977 cites W2146888187 @default.
• W2144054977 cites W2153425207 @default.
• W2144054977 cites W2155184228 @default.
• W2144054977 cites W2160496747 @default.
• W2144054977 cites W2160502767 @default.
• W2144054977 cites W2161458737 @default.
• W2144054977 cites W2162812395 @default.
• W2144054977 cites W2169879234 @default.
• W2144054977 doi "https://doi.org/10.1128/iai.00606-12" @default.
• W2144054977 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3486050" @default.
• W2144054977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22966041" @default.
• W2144054977 hasPublicationYear "2012" @default.
• W2144054977 type Work @default.
• W2144054977 sameAs 2144054977 @default.
• W2144054977 citedByCount "27" @default.
• W2144054977 countsByYear W21440549772013 @default.
• W2144054977 countsByYear W21440549772014 @default.
• W2144054977 countsByYear W21440549772015 @default.
• W2144054977 countsByYear W21440549772016 @default.
• W2144054977 countsByYear W21440549772017 @default.
• W2144054977 countsByYear W21440549772018 @default.
• W2144054977 countsByYear W21440549772019 @default.
• W2144054977 countsByYear W21440549772020 @default.
• W2144054977 countsByYear W21440549772021 @default.
• W2144054977 countsByYear W21440549772022 @default.
• W2144054977 countsByYear W21440549772023 @default.
• W2144054977 crossrefType "journal-article" @default.
• W2144054977 hasAuthorship W2144054977A5006099075 @default.
• W2144054977 hasAuthorship W2144054977A5016076855 @default.
• W2144054977 hasAuthorship W2144054977A5060699297 @default.
• W2144054977 hasAuthorship W2144054977A5065518781 @default.
• W2144054977 hasBestOaLocation W21440549771 @default.
• W2144054977 hasConcept C104317684 @default.
• W2144054977 hasConcept C136449434 @default.
• W2144054977 hasConcept C203014093 @default.
• W2144054977 hasConcept C2776914184 @default.
• W2144054977 hasConcept C2778222588 @default.
• W2144054977 hasConcept C553184892 @default.
• W2144054977 hasConcept C55493867 @default.
• W2144054977 hasConcept C60987743 @default.
• W2144054977 hasConcept C86803240 @default.
• W2144054977 hasConcept C8891405 @default.
• W2144054977 hasConcept C89423630 @default.
• W2144054977 hasConceptScore W2144054977C104317684 @default.
• W2144054977 hasConceptScore W2144054977C136449434 @default.

• next