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- W2144067912 abstract "TGF-β and Foxp3 expressions are crucial for the induction and functional activity of CD4+Foxp3+ regulatory T (iTreg) cells. Here, we demonstrate that although TGF-β-primed CD8+ cells display much lower Foxp3 expression, their suppressive capacity is equivalent to that of CD4+ iTreg cells, and both Foxp3− and Foxp3+ CD8+ subsets have suppressive activities in vitro and in vivo. CD8+Foxp3− iTreg cells produce little IFN-γ but almost no IL-2, and display a typical anergic phenotype. Among phenotypic markers expressed in CD8+Foxp3− cells, we identify CD103 expression particularly crucial for the generation and function of this subset. Moreover, IL-10 and TGF-β signals rather than cytotoxicity mediate the suppressive effect of this novel Treg population. Therefore, TGF-β can induce both CD8+Foxp3− and CD8+Foxp3+ iTreg subsets, which may represent the unique immunoregulatory means to treat autoimmune and inflammatory diseases." @default.
- W2144067912 created "2016-06-24" @default.
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- W2144067912 date "2013-07-15" @default.
- W2144067912 modified "2023-10-18" @default.
- W2144067912 title "Phenotypic and functional characteristic of a newly identified CD8+Foxp3−CD103+ regulatory T cells" @default.
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- W2144067912 doi "https://doi.org/10.1093/jmcb/mjt026" @default.
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