FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144080504> ?p ?o ?g. }

• W2144080504 endingPage "586" @default.
• W2144080504 startingPage "580" @default.
• W2144080504 abstract "Helper T (Th) cells are classified into Th1 and Th2 subsets based on cytokine production and the Th1/Th2 paradigm explains differences in inflammatory effector pathways in various human diseases. Membranous nephropathy (MN) is an immune complex disease associated with Th2 nephritogenic immune response. However, overproduction of interleukin (IL)-4, a principal Th2 cytokine, has not been demonstrated. We investigated Th1/Th2 cytokine production by peripheral Th cells and its association with the degree of proteinuria in MN.We analysed production of Th1/Th2 cytokines, interferon (IFN)-gamma and IL-4 by peripheral Th cells, using an intracellular cytokine detection method with flow cytometry in patients with MN (n = 24). The data were compared with data from healthy subjects (n = 51), subjects with minimal change nephrotic syndrome (MCNS; n = 13) and subjects with focal segmental glomerulosclerosis (FSGS; n = 12). We compared the percentages of IFN-gamma+ and IL-4+ Th cells and the peripheral Th1/Th2 ratio (IFN-gamma/IL-4 ratio) among the four groups. We also examined the association of IFN-gamma and IL-4 production with clinical parameters of MN.The mean percentage of IL-4+ cells in MN (3.9+/-1.2%) was significantly higher than in the control (2.4+/-1.0%), MCNS (2.3+/-1.4%) and FSGS (2.3+/-1.2%) groups (P<0.001, respectively). The Th1/Th2 ratio was significantly lower in MN (5.3+/-2.0) than in the control (8.2+/-4.2, P<0.05), MCNS (10.0+/-5.3, P<0.01) and FSGS (10.2+/-5.3, P<0.01) groups. Moreover, the percentage of IL-4+ cells correlated significantly with the amount of proteinuria in MN (r = 0.57, P<0.01).IL-4 production by peripheral Th cells is up-regulated in patients with MN and correlated with the severity of proteinuria. Intracellular cytokine analysis could be a useful index in idiopathic MN." @default.
• W2144080504 created "2016-06-24" @default.
• W2144080504 creator A5005214262 @default.
• W2144080504 creator A5009478925 @default.
• W2144080504 creator A5019098399 @default.
• W2144080504 creator A5029569870 @default.
• W2144080504 creator A5033385933 @default.
• W2144080504 creator A5033923820 @default.
• W2144080504 creator A5040607914 @default.
• W2144080504 creator A5053781721 @default.
• W2144080504 creator A5068185380 @default.
• W2144080504 creator A5068552500 @default.
• W2144080504 creator A5072359193 @default.
• W2144080504 date "2004-02-06" @default.
• W2144080504 modified "2023-09-26" @default.
• W2144080504 title "Up-regulated interleukin-4 production by peripheral T-helper cells in idiopathic membranous nephropathy" @default.
• W2144080504 cites W1964602645 @default.
• W2144080504 cites W1978840204 @default.
• W2144080504 cites W1989220647 @default.
• W2144080504 cites W1990614192 @default.
• W2144080504 cites W2041259631 @default.
• W2144080504 cites W2041647537 @default.
• W2144080504 cites W2055669282 @default.
• W2144080504 cites W2055994644 @default.
• W2144080504 cites W2068819666 @default.
• W2144080504 cites W2077608765 @default.
• W2144080504 cites W2082601612 @default.
• W2144080504 cites W2084194895 @default.
• W2144080504 cites W2104895892 @default.
• W2144080504 cites W2123994245 @default.
• W2144080504 cites W2124360695 @default.
• W2144080504 cites W2141672711 @default.
• W2144080504 cites W2327282663 @default.
• W2144080504 doi "https://doi.org/10.1093/ndt/gfg572" @default.
• W2144080504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14767012" @default.
• W2144080504 hasPublicationYear "2004" @default.
• W2144080504 type Work @default.
• W2144080504 sameAs 2144080504 @default.
• W2144080504 citedByCount "54" @default.
• W2144080504 countsByYear W21440805042012 @default.
• W2144080504 countsByYear W21440805042013 @default.
• W2144080504 countsByYear W21440805042014 @default.
• W2144080504 countsByYear W21440805042015 @default.
• W2144080504 countsByYear W21440805042016 @default.
• W2144080504 countsByYear W21440805042017 @default.
• W2144080504 countsByYear W21440805042019 @default.
• W2144080504 countsByYear W21440805042020 @default.
• W2144080504 countsByYear W21440805042021 @default.
• W2144080504 countsByYear W21440805042022 @default.
• W2144080504 countsByYear W21440805042023 @default.
• W2144080504 crossrefType "journal-article" @default.
• W2144080504 hasAuthorship W2144080504A5005214262 @default.
• W2144080504 hasAuthorship W2144080504A5009478925 @default.
• W2144080504 hasAuthorship W2144080504A5019098399 @default.
• W2144080504 hasAuthorship W2144080504A5029569870 @default.
• W2144080504 hasAuthorship W2144080504A5033385933 @default.
• W2144080504 hasAuthorship W2144080504A5033923820 @default.
• W2144080504 hasAuthorship W2144080504A5040607914 @default.
• W2144080504 hasAuthorship W2144080504A5053781721 @default.
• W2144080504 hasAuthorship W2144080504A5068185380 @default.
• W2144080504 hasAuthorship W2144080504A5068552500 @default.
• W2144080504 hasAuthorship W2144080504A5072359193 @default.
• W2144080504 hasConcept C126322002 @default.
• W2144080504 hasConcept C134018914 @default.
• W2144080504 hasConcept C187316574 @default.
• W2144080504 hasConcept C191732599 @default.
• W2144080504 hasConcept C203014093 @default.
• W2144080504 hasConcept C2775946357 @default.
• W2144080504 hasConcept C2777747828 @default.
• W2144080504 hasConcept C2778415529 @default.
• W2144080504 hasConcept C2778690821 @default.
• W2144080504 hasConcept C2778930706 @default.
• W2144080504 hasConcept C2780091579 @default.
• W2144080504 hasConcept C2780368995 @default.
• W2144080504 hasConcept C2780841837 @default.
• W2144080504 hasConcept C2781184683 @default.
• W2144080504 hasConcept C555293320 @default.
• W2144080504 hasConcept C71924100 @default.
• W2144080504 hasConcept C8891405 @default.
• W2144080504 hasConceptScore W2144080504C126322002 @default.
• W2144080504 hasConceptScore W2144080504C134018914 @default.
• W2144080504 hasConceptScore W2144080504C187316574 @default.
• W2144080504 hasConceptScore W2144080504C191732599 @default.
• W2144080504 hasConceptScore W2144080504C203014093 @default.
• W2144080504 hasConceptScore W2144080504C2775946357 @default.
• W2144080504 hasConceptScore W2144080504C2777747828 @default.
• W2144080504 hasConceptScore W2144080504C2778415529 @default.
• W2144080504 hasConceptScore W2144080504C2778690821 @default.
• W2144080504 hasConceptScore W2144080504C2778930706 @default.
• W2144080504 hasConceptScore W2144080504C2780091579 @default.
• W2144080504 hasConceptScore W2144080504C2780368995 @default.
• W2144080504 hasConceptScore W2144080504C2780841837 @default.
• W2144080504 hasConceptScore W2144080504C2781184683 @default.
• W2144080504 hasConceptScore W2144080504C555293320 @default.
• W2144080504 hasConceptScore W2144080504C71924100 @default.
• W2144080504 hasConceptScore W2144080504C8891405 @default.
• W2144080504 hasIssue "3" @default.
• W2144080504 hasLocation W21440805041 @default.

• next