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• W2144081856 abstract "Meiotic DNA double strand breaks (DSBs) are indicated at leptotene by the phosphorylated form of histone H2AX (γ-H2AX). In contrast to previous studies, we identified on both zygotene and pachytene chromosomes two distinct types of γ-H2AX foci: multiple small (S) foci located along autosomal synaptonemal complexes (SCs) and larger signals on chromatin loops (L-foci). The S-foci number gradually declined throughout pachytene, in parallel with the repair of DSBs monitored by repair proteins suggesting that S-foci mark DSB repair events. We validated this interpretation by showing the absence of S-foci in Spo11–/– spermatocytes. By contrast, the L-foci number was very low through pachytene. Based on the analysis of γ-H2AX labeling after irradiation of spermatocytes, the formation of DSBs clearly induced L-foci formation. Upon DSB repair, these foci appear to be processed and lead to the above mentioned S-foci. The presence of L-foci in wild-type pachytene and diplotene could therefore reflect delayed or unregulated DSB repair events. Interestingly, their distribution was different in Spo11+/– spermatocytes compared with Spo11+/+ spermatocytes, where DSB repair might be differently regulated as a response to homeostatic control of crossing-over. The presence of these L-foci in Spo11–/– spermatocytes raises the interesting possibility of yet uncharacterized alterations in DNA or chromosome structure in Spo11–/– cells." @default.
• W2144081856 created "2016-06-24" @default.
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• W2144081856 date "2007-05-15" @default.
• W2144081856 modified "2023-09-30" @default.
• W2144081856 title "Characterization of<i>Spo11</i>-dependent and independent phospho-H2AX foci during meiotic prophase I in the male mouse" @default.
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• W2144081856 doi "https://doi.org/10.1242/jcs.004945" @default.
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