FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144083283> ?p ?o ?g. }

• W2144083283 endingPage "202" @default.
• W2144083283 startingPage "191" @default.
• W2144083283 abstract "Abstract During sex determination, the sisterlessA (sisA) gene functions as one of four X:A numerator elements that set the alternative male or female regulatory states of the switch gene Sex-lethal. In somatic cells, sisA functions specifically in sex determination, but its expression pattern also hints at a role in the yolk cell, a syncytial structure believed to provide energy and nutrients to the developing embryo. Previous studies of sisA have been limited by the lack of a null allele, leaving open the possibility that sisA has additional functions. Here we report the isolation and molecular characterization of four new sisA alleles including two null mutations. Our findings highlight key aspects of sisA structure-function and reveal important qualitative differences between the effects of sisA and the other strong X:A numerator element, sisterlessB, on Sex-lethal expression. We use genetic, expression, clonal, and phenotypic analyses to demonstrate that sisA has an essential function in the yolk nuclei of both sexes. In the absence of sisA, endoderm migration and midgut formation are blocked, suggesting that the yolk cell may have a direct role in larval gut development. To our knowledge, this is the first report of a requirement for the yolk nuclei in Drosophila development." @default.
• W2144083283 created "2016-06-24" @default.
• W2144083283 creator A5003900096 @default.
• W2144083283 creator A5050039161 @default.
• W2144083283 creator A5051593189 @default.
• W2144083283 creator A5063546371 @default.
• W2144083283 date "2000-05-01" @default.
• W2144083283 modified "2023-10-16" @default.
• W2144083283 title "The <i>Drosophila melanogaster</i> Sex Determination Gene <i>sisA</i> Is Required in Yolk Nuclei for Midgut Formation" @default.
• W2144083283 cites W1750518603 @default.
• W2144083283 cites W1875235137 @default.
• W2144083283 cites W1881050461 @default.
• W2144083283 cites W1903039683 @default.
• W2144083283 cites W1920945986 @default.
• W2144083283 cites W1960622425 @default.
• W2144083283 cites W1972889806 @default.
• W2144083283 cites W1973738440 @default.
• W2144083283 cites W1975788358 @default.
• W2144083283 cites W1990068727 @default.
• W2144083283 cites W1991136044 @default.
• W2144083283 cites W1993930606 @default.
• W2144083283 cites W2000477490 @default.
• W2144083283 cites W2008076522 @default.
• W2144083283 cites W2028755161 @default.
• W2144083283 cites W2040069098 @default.
• W2144083283 cites W2044736491 @default.
• W2144083283 cites W2057307047 @default.
• W2144083283 cites W2069723519 @default.
• W2144083283 cites W2088667155 @default.
• W2144083283 cites W2109126669 @default.
• W2144083283 cites W2110201107 @default.
• W2144083283 cites W2111648532 @default.
• W2144083283 cites W2127204620 @default.
• W2144083283 cites W2135842590 @default.
• W2144083283 cites W2144784433 @default.
• W2144083283 cites W2152582492 @default.
• W2144083283 cites W2152651471 @default.
• W2144083283 cites W2157791218 @default.
• W2144083283 cites W2159077785 @default.
• W2144083283 cites W2169580261 @default.
• W2144083283 cites W2170677464 @default.
• W2144083283 cites W2188542864 @default.
• W2144083283 cites W2330980885 @default.
• W2144083283 cites W4210566761 @default.
• W2144083283 doi "https://doi.org/10.1093/genetics/155.1.191" @default.
• W2144083283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461051" @default.
• W2144083283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10790394" @default.
• W2144083283 hasPublicationYear "2000" @default.
• W2144083283 type Work @default.
• W2144083283 sameAs 2144083283 @default.
• W2144083283 citedByCount "18" @default.
• W2144083283 countsByYear W21440832832014 @default.
• W2144083283 countsByYear W21440832832015 @default.
• W2144083283 countsByYear W21440832832017 @default.
• W2144083283 countsByYear W21440832832019 @default.
• W2144083283 countsByYear W21440832832020 @default.
• W2144083283 crossrefType "journal-article" @default.
• W2144083283 hasAuthorship W2144083283A5003900096 @default.
• W2144083283 hasAuthorship W2144083283A5050039161 @default.
• W2144083283 hasAuthorship W2144083283A5051593189 @default.
• W2144083283 hasAuthorship W2144083283A5063546371 @default.
• W2144083283 hasBestOaLocation W21440832831 @default.
• W2144083283 hasConcept C104317684 @default.
• W2144083283 hasConcept C134305767 @default.
• W2144083283 hasConcept C150149183 @default.
• W2144083283 hasConcept C150194340 @default.
• W2144083283 hasConcept C173758957 @default.
• W2144083283 hasConcept C180754005 @default.
• W2144083283 hasConcept C18903297 @default.
• W2144083283 hasConcept C2780104201 @default.
• W2144083283 hasConcept C2781321622 @default.
• W2144083283 hasConcept C54355233 @default.
• W2144083283 hasConcept C57708383 @default.
• W2144083283 hasConcept C59822182 @default.
• W2144083283 hasConcept C86803240 @default.
• W2144083283 hasConcept C95444343 @default.
• W2144083283 hasConceptScore W2144083283C104317684 @default.
• W2144083283 hasConceptScore W2144083283C134305767 @default.
• W2144083283 hasConceptScore W2144083283C150149183 @default.
• W2144083283 hasConceptScore W2144083283C150194340 @default.
• W2144083283 hasConceptScore W2144083283C173758957 @default.
• W2144083283 hasConceptScore W2144083283C180754005 @default.
• W2144083283 hasConceptScore W2144083283C18903297 @default.
• W2144083283 hasConceptScore W2144083283C2780104201 @default.
• W2144083283 hasConceptScore W2144083283C2781321622 @default.
• W2144083283 hasConceptScore W2144083283C54355233 @default.
• W2144083283 hasConceptScore W2144083283C57708383 @default.
• W2144083283 hasConceptScore W2144083283C59822182 @default.
• W2144083283 hasConceptScore W2144083283C86803240 @default.
• W2144083283 hasConceptScore W2144083283C95444343 @default.
• W2144083283 hasIssue "1" @default.
• W2144083283 hasLocation W21440832831 @default.
• W2144083283 hasLocation W21440832832 @default.
• W2144083283 hasOpenAccess W2144083283 @default.
• W2144083283 hasPrimaryLocation W21440832831 @default.
• W2144083283 hasRelatedWork W1821487627 @default.
• W2144083283 hasRelatedWork W1980317616 @default.
• W2144083283 hasRelatedWork W2086235846 @default.

• next