Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144088042> ?p ?o ?g. }
- W2144088042 endingPage "269" @default.
- W2144088042 startingPage "257" @default.
- W2144088042 abstract "Based on the results of in vivo studies, the thiazoloazepine derivative B-HT 920 has been proposed to be a selective agonist of dopamine autoreceptors. In the present study, we investigated the effects of B-HT 920 in two functional in vitro model systems of D2 receptors and compared these effects with the effects of the classical D2 agonist LY 171555. B-HT 920 and LY 171555 concentration dependently inhibited the electrically evoked release of radiolabeled dopamine and acetylcholine and the forskolin-induced stimulation of adenylate cyclase activity in rat striatal tissue slices with comparable efficacies. In striatal tissue slices prepared after 6-hydroxydopamine-induced destruction of dopaminergic terminals, both drugs were still able to inhibit forskolin-stimulated adenylate cyclase activity with a efficacy similar to that in tissue obtained from unlesioned rats. It is concluded that, in vitro, B-HT 920 is an agonist at both presynaptic and 'normosensitive' postsynaptic D2 receptors showing relatively high intrinsic activity." @default.
- W2144088042 created "2016-06-24" @default.
- W2144088042 creator A5051714464 @default.
- W2144088042 creator A5058153606 @default.
- W2144088042 creator A5076010133 @default.
- W2144088042 creator A5088432855 @default.
- W2144088042 creator A5089717369 @default.
- W2144088042 creator A5090262285 @default.
- W2144088042 date "1990-10-01" @default.
- W2144088042 modified "2023-09-27" @default.
- W2144088042 title "Lack of a dopamine autoreceptor selective profile of B-HT 920 in functional in vitro model systems of D2 receptors in rat striatum" @default.
- W2144088042 cites W1757846929 @default.
- W2144088042 cites W1789459360 @default.
- W2144088042 cites W1929648989 @default.
- W2144088042 cites W1963960260 @default.
- W2144088042 cites W1965008238 @default.
- W2144088042 cites W1966431608 @default.
- W2144088042 cites W1967342987 @default.
- W2144088042 cites W1968082942 @default.
- W2144088042 cites W1968726584 @default.
- W2144088042 cites W1969378517 @default.
- W2144088042 cites W1969704831 @default.
- W2144088042 cites W1973544416 @default.
- W2144088042 cites W197594336 @default.
- W2144088042 cites W1976682355 @default.
- W2144088042 cites W1980330482 @default.
- W2144088042 cites W1981896177 @default.
- W2144088042 cites W1983665119 @default.
- W2144088042 cites W1983884757 @default.
- W2144088042 cites W1999510004 @default.
- W2144088042 cites W2002159489 @default.
- W2144088042 cites W2002748061 @default.
- W2144088042 cites W2004094484 @default.
- W2144088042 cites W2004791505 @default.
- W2144088042 cites W2010299478 @default.
- W2144088042 cites W2010489445 @default.
- W2144088042 cites W2015129706 @default.
- W2144088042 cites W2017110037 @default.
- W2144088042 cites W2022296995 @default.
- W2144088042 cites W2024994836 @default.
- W2144088042 cites W2026442682 @default.
- W2144088042 cites W2028832773 @default.
- W2144088042 cites W2032957755 @default.
- W2144088042 cites W2037215386 @default.
- W2144088042 cites W2037612886 @default.
- W2144088042 cites W2042066622 @default.
- W2144088042 cites W2043881516 @default.
- W2144088042 cites W2046747394 @default.
- W2144088042 cites W2049438443 @default.
- W2144088042 cites W2050930230 @default.
- W2144088042 cites W2051481767 @default.
- W2144088042 cites W2056700078 @default.
- W2144088042 cites W2056831293 @default.
- W2144088042 cites W2061805224 @default.
- W2144088042 cites W2072543964 @default.
- W2144088042 cites W2077108130 @default.
- W2144088042 cites W2077366586 @default.
- W2144088042 cites W2083307368 @default.
- W2144088042 cites W2084688297 @default.
- W2144088042 cites W2092752413 @default.
- W2144088042 cites W2095976264 @default.
- W2144088042 cites W2099793114 @default.
- W2144088042 cites W2144939635 @default.
- W2144088042 cites W2168393661 @default.
- W2144088042 cites W2169503005 @default.
- W2144088042 cites W2227591748 @default.
- W2144088042 cites W2259393497 @default.
- W2144088042 cites W2318569097 @default.
- W2144088042 cites W2320291967 @default.
- W2144088042 cites W2339240651 @default.
- W2144088042 cites W2460085704 @default.
- W2144088042 cites W2484632383 @default.
- W2144088042 doi "https://doi.org/10.1016/0014-2999(90)90012-u" @default.
- W2144088042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1980248" @default.
- W2144088042 hasPublicationYear "1990" @default.
- W2144088042 type Work @default.
- W2144088042 sameAs 2144088042 @default.
- W2144088042 citedByCount "14" @default.
- W2144088042 crossrefType "journal-article" @default.
- W2144088042 hasAuthorship W2144088042A5051714464 @default.
- W2144088042 hasAuthorship W2144088042A5058153606 @default.
- W2144088042 hasAuthorship W2144088042A5076010133 @default.
- W2144088042 hasAuthorship W2144088042A5088432855 @default.
- W2144088042 hasAuthorship W2144088042A5089717369 @default.
- W2144088042 hasAuthorship W2144088042A5090262285 @default.
- W2144088042 hasConcept C120069818 @default.
- W2144088042 hasConcept C126322002 @default.
- W2144088042 hasConcept C134018914 @default.
- W2144088042 hasConcept C137183658 @default.
- W2144088042 hasConcept C170493617 @default.
- W2144088042 hasConcept C185592680 @default.
- W2144088042 hasConcept C197341189 @default.
- W2144088042 hasConcept C24998067 @default.
- W2144088042 hasConcept C2778938600 @default.
- W2144088042 hasConcept C2779276759 @default.
- W2144088042 hasConcept C2780062018 @default.
- W2144088042 hasConcept C44208683 @default.
- W2144088042 hasConcept C513476851 @default.