FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144089778> ?p ?o ?g. }

• W2144089778 endingPage "8" @default.
• W2144089778 startingPage "1" @default.
• W2144089778 abstract "It has been suggested that the heteromorphic X and Y sex chromosomes of the mammal arose from a homomorphic pair of homologous autosomes and that the X changed little during evolution, while the Y lost most of its genetic material to become a specialized testis-inducer (Ohno, 1967). Of course the sex determining role of the Y chromosome is borne out empirically: in the presence of the Y, the initially indifferent fetal gonad becomes a testis and in the absence of the Y, the gonad becomes an ovary. The newly organized testis secretes testosterone (to which both XV and XX cells can respond); this induces the secondary sex characteristics of the male and in the absence of testosterone, the embryo becomes a female (Jost, 1970; Wilson and MacDonald, 1978). Yet the scheme is rather more complicated, for presence of the V chromosome does not guarantee testicular differentiation and absence of the V does not guarantee ovarian differentiation; XV gonads may become ovaries and XX gonads may become testes and either may become ovotestes. Indeed there is a growing body of evidence that it is not the V chromosome itself that induces the testis, but a serologically defined, phylogenetically stable cell membrane component called ‘H-V antigen,’ synthesis of which is dependent either directly or indirectly on V chromosomal genes. In vitro, for example, XX cells of the dissociated neonatal ovary form seminiferous tubule-like aggregates in the presence of H-V antigen, whereas in the presence of H-V antibody, XV cells of the dissociated neonatal testis form ovarian ‘folliculoids.’ In vivo, H-V antigen is routinely detected in association with testicular differentiation, despite karyotype or secondary sex phenotype: XX males are H-V antigen positive (H Y+) and so are XV females with the testicular feminization syndrome; remarkably, XX true hermaphrodites (possessing both testis and ovary) manifest H-V phenotypes intermediate between those of normal male and female (reviewed in Ohno, 1979). Thus cell surface immunogenetics has provided a valuable new testing ground for the study of sex determination and reproductive biology. In this paper I shall review some of the advances of the past few years, emphasizing studies of abnormal differentiation in the human gonad. I intend to show that ovarian organogenesis of the XV gonad and testicular or ovotesticular differentiation of the XX gonad, may each be attributed to errors of synthesis, dissemination and binding of serologically detectable H-V antigen." @default.
• W2144089778 created "2016-06-24" @default.
• W2144089778 creator A5004284757 @default.
• W2144089778 date "1980-02-01" @default.
• W2144089778 modified "2023-09-23" @default.
• W2144089778 title "The Dysgenetic Gonad: Aberrant Testicular Differentiation" @default.
• W2144089778 cites W137498602 @default.
• W2144089778 cites W149345860 @default.
• W2144089778 cites W1965371268 @default.
• W2144089778 cites W1970863997 @default.
• W2144089778 cites W1975362128 @default.
• W2144089778 cites W1977166607 @default.
• W2144089778 cites W1990444091 @default.
• W2144089778 cites W2000267439 @default.
• W2144089778 cites W2004885325 @default.
• W2144089778 cites W2007227212 @default.
• W2144089778 cites W2011499667 @default.
• W2144089778 cites W2014085085 @default.
• W2144089778 cites W2014497654 @default.
• W2144089778 cites W2021129979 @default.
• W2144089778 cites W2030552050 @default.
• W2144089778 cites W2040167197 @default.
• W2144089778 cites W2067935567 @default.
• W2144089778 cites W2076826161 @default.
• W2144089778 cites W2084493244 @default.
• W2144089778 cites W2089112837 @default.
• W2144089778 cites W2091637548 @default.
• W2144089778 cites W2092724850 @default.
• W2144089778 cites W2144737343 @default.
• W2144089778 cites W2148531855 @default.
• W2144089778 cites W2166520693 @default.
• W2144089778 cites W2335726945 @default.
• W2144089778 cites W2409373478 @default.
• W2144089778 cites W2428008639 @default.
• W2144089778 cites W2481269125 @default.
• W2144089778 cites W2885503625 @default.
• W2144089778 cites W654747701 @default.
• W2144089778 cites W1569108076 @default.
• W2144089778 doi "https://doi.org/10.1095/biolreprod22.1.1" @default.
• W2144089778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6991006" @default.
• W2144089778 hasPublicationYear "1980" @default.
• W2144089778 type Work @default.
• W2144089778 sameAs 2144089778 @default.
• W2144089778 citedByCount "17" @default.
• W2144089778 countsByYear W21440897782022 @default.
• W2144089778 crossrefType "journal-article" @default.
• W2144089778 hasAuthorship W2144089778A5004284757 @default.
• W2144089778 hasBestOaLocation W21440897781 @default.
• W2144089778 hasConcept C104317684 @default.
• W2144089778 hasConcept C134018914 @default.
• W2144089778 hasConcept C2781471917 @default.
• W2144089778 hasConcept C54355233 @default.
• W2144089778 hasConcept C63405245 @default.
• W2144089778 hasConcept C86803240 @default.
• W2144089778 hasConcept C95444343 @default.
• W2144089778 hasConceptScore W2144089778C104317684 @default.
• W2144089778 hasConceptScore W2144089778C134018914 @default.
• W2144089778 hasConceptScore W2144089778C2781471917 @default.
• W2144089778 hasConceptScore W2144089778C54355233 @default.
• W2144089778 hasConceptScore W2144089778C63405245 @default.
• W2144089778 hasConceptScore W2144089778C86803240 @default.
• W2144089778 hasConceptScore W2144089778C95444343 @default.
• W2144089778 hasIssue "1" @default.
• W2144089778 hasLocation W21440897781 @default.
• W2144089778 hasLocation W21440897782 @default.
• W2144089778 hasOpenAccess W2144089778 @default.
• W2144089778 hasPrimaryLocation W21440897781 @default.
• W2144089778 hasRelatedWork W1998201951 @default.
• W2144089778 hasRelatedWork W2000156827 @default.
• W2144089778 hasRelatedWork W2046316415 @default.
• W2144089778 hasRelatedWork W2054249716 @default.
• W2144089778 hasRelatedWork W2098048817 @default.
• W2144089778 hasRelatedWork W2807293741 @default.
• W2144089778 hasRelatedWork W3159243450 @default.
• W2144089778 hasRelatedWork W3183375644 @default.
• W2144089778 hasRelatedWork W4377041435 @default.
• W2144089778 hasRelatedWork W622600102 @default.
• W2144089778 hasVolume "22" @default.
• W2144089778 isParatext "false" @default.
• W2144089778 isRetracted "false" @default.
• W2144089778 magId "2144089778" @default.
• W2144089778 workType "article" @default.