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• W2144090400 abstract "The nuclear p300 protein functions as a co-activator of gene transcription. Here we show that p300 works as a co-activator of the transcription factor Pax 8 on the thyroperoxidase gene promoter. Consistent with its role as co-activator, p300 potentiates Pax 8-activated transcription. Furthermore, we provide evidence supporting the formation of a complex between both factors in vivo and in vitro. This interaction involves the amino-terminal and CH3 domains of p300 and the trans-activation domain of Pax 8 at its carboxyl-terminal end. We show that the CH3 domain is crucial for the co-activator role of p300 on the thyroperoxidase gene promoter. In agreement with our finding and with the ability of the adenoviral protein E1A to bind p300, we show that E1A down-regulates Pax 8 activity." @default.
• W2144090400 created "2016-06-24" @default.
• W2144090400 creator A5073690467 @default.
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• W2144090400 date "2000-11-01" @default.
• W2144090400 modified "2023-10-15" @default.
• W2144090400 title "Role for p300 in Pax 8 Induction of Thyroperoxidase Gene Expression" @default.
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• W2144090400 doi "https://doi.org/10.1074/jbc.m003043200" @default.
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