FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144107170> ?p ?o ?g. }

• W2144107170 endingPage "4966" @default.
• W2144107170 startingPage "4954" @default.
• W2144107170 abstract "Abstract Despite promising results in the use of anti-epidermal growth factor receptor (EGFR) Abs for cancer therapy, several issues remain to be addressed. An increasing emphasis is being placed on immune effector mechanisms. It has become clear for other Abs directed to tumor targets that their effects involve the adaptive immunity, mainly by the contribution of Fc region-mediated mechanisms. Given the relevance of EGFR signaling for tumor biology, we wonder whether the oncogene inhibition could contribute to Ab-induced vaccine effect. In a mouse model in which 7A7 (an anti-murine EGFR Ab) and AG1478 (an EGFR-tyrosine kinase inhibitor) displayed potent antimetastatic activities, depletion experiments revealed that only in the case of the Ab, the effect was dependent on CD4+ and CD8+ T cells. Correspondingly, 7A7 administration elicited a remarkable tumor-specific CTL response in hosts. Importantly, experiments using 7A7 F(ab′)2 suggested that in vivo Ab-mediated EGFR blockade may play an important role in the linkage with adaptive immunity. Addressing the possible mechanism involved in this effect, we found quantitative and qualitative differences between 7A7 and AG1478-induced apoptosis. EGFR blocking by 7A7 not only prompted a higher proapoptotic effect on tumor metastases compared with AG1478, but also was able to induce apoptosis with immunogenic potential in an Fc-independent manner. As expected, 7A7 but not AG1478 stimulated exposure of danger signals on tumor cells. Subcutaneous injection of 7A7-treated tumor cells induced an antitumor immune response. This is the first report, to our knowledge, of a tumor-specific CTL response generated by Ab-mediated EGFR inhibition, suggesting an important contribution of immunogenic apoptosis to this effect." @default.
• W2144107170 created "2016-06-24" @default.
• W2144107170 creator A5006933921 @default.
• W2144107170 creator A5008047182 @default.
• W2144107170 creator A5026879931 @default.
• W2144107170 creator A5034761993 @default.
• W2144107170 creator A5051712285 @default.
• W2144107170 creator A5052549277 @default.
• W2144107170 creator A5065298283 @default.
• W2144107170 creator A5066400814 @default.
• W2144107170 creator A5078402412 @default.
• W2144107170 date "2011-11-15" @default.
• W2144107170 modified "2023-10-01" @default.
• W2144107170 title "Induction of Immunogenic Apoptosis by Blockade of Epidermal Growth Factor Receptor Activation with a Specific Antibody" @default.
• W2144107170 cites W1561591381 @default.
• W2144107170 cites W1600186066 @default.
• W2144107170 cites W1601063160 @default.
• W2144107170 cites W1610114835 @default.
• W2144107170 cites W1782545213 @default.
• W2144107170 cites W1930879408 @default.
• W2144107170 cites W1963503658 @default.
• W2144107170 cites W1963633622 @default.
• W2144107170 cites W1964321121 @default.
• W2144107170 cites W1967329857 @default.
• W2144107170 cites W1970346668 @default.
• W2144107170 cites W1972394365 @default.
• W2144107170 cites W1976681938 @default.
• W2144107170 cites W1984068314 @default.
• W2144107170 cites W1985987145 @default.
• W2144107170 cites W1987720155 @default.
• W2144107170 cites W1994048581 @default.
• W2144107170 cites W1994097025 @default.
• W2144107170 cites W1996952962 @default.
• W2144107170 cites W2001155346 @default.
• W2144107170 cites W2002865239 @default.
• W2144107170 cites W2009573953 @default.
• W2144107170 cites W2027536435 @default.
• W2144107170 cites W2030177319 @default.
• W2144107170 cites W2039950956 @default.
• W2144107170 cites W2044504047 @default.
• W2144107170 cites W2049909641 @default.
• W2144107170 cites W2054149360 @default.
• W2144107170 cites W2055132644 @default.
• W2144107170 cites W2056926226 @default.
• W2144107170 cites W2057556028 @default.
• W2144107170 cites W2058676815 @default.
• W2144107170 cites W2063856952 @default.
• W2144107170 cites W2064548992 @default.
• W2144107170 cites W2066471812 @default.
• W2144107170 cites W2066982596 @default.
• W2144107170 cites W2068758235 @default.
• W2144107170 cites W2069377326 @default.
• W2144107170 cites W2069749184 @default.
• W2144107170 cites W2077353205 @default.
• W2144107170 cites W2090750060 @default.
• W2144107170 cites W2091103707 @default.
• W2144107170 cites W2094882473 @default.
• W2144107170 cites W2100886460 @default.
• W2144107170 cites W2106409098 @default.
• W2144107170 cites W2114101532 @default.
• W2144107170 cites W2120161817 @default.
• W2144107170 cites W2122706875 @default.
• W2144107170 cites W2123469465 @default.
• W2144107170 cites W2124749346 @default.
• W2144107170 cites W2130930654 @default.
• W2144107170 cites W2139115350 @default.
• W2144107170 cites W2142153200 @default.
• W2144107170 cites W2155384808 @default.
• W2144107170 cites W2157824687 @default.
• W2144107170 cites W2166676682 @default.
• W2144107170 doi "https://doi.org/10.4049/jimmunol.1003477" @default.
• W2144107170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21984704" @default.
• W2144107170 hasPublicationYear "2011" @default.
• W2144107170 type Work @default.
• W2144107170 sameAs 2144107170 @default.
• W2144107170 citedByCount "81" @default.
• W2144107170 countsByYear W21441071702012 @default.
• W2144107170 countsByYear W21441071702013 @default.
• W2144107170 countsByYear W21441071702014 @default.
• W2144107170 countsByYear W21441071702015 @default.
• W2144107170 countsByYear W21441071702016 @default.
• W2144107170 countsByYear W21441071702017 @default.
• W2144107170 countsByYear W21441071702018 @default.
• W2144107170 countsByYear W21441071702019 @default.
• W2144107170 countsByYear W21441071702020 @default.
• W2144107170 countsByYear W21441071702021 @default.
• W2144107170 countsByYear W21441071702022 @default.
• W2144107170 countsByYear W21441071702023 @default.
• W2144107170 crossrefType "journal-article" @default.
• W2144107170 hasAuthorship W2144107170A5006933921 @default.
• W2144107170 hasAuthorship W2144107170A5008047182 @default.
• W2144107170 hasAuthorship W2144107170A5026879931 @default.
• W2144107170 hasAuthorship W2144107170A5034761993 @default.
• W2144107170 hasAuthorship W2144107170A5051712285 @default.
• W2144107170 hasAuthorship W2144107170A5052549277 @default.
• W2144107170 hasAuthorship W2144107170A5065298283 @default.
• W2144107170 hasAuthorship W2144107170A5066400814 @default.
• W2144107170 hasAuthorship W2144107170A5078402412 @default.

• next