Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144109968> ?p ?o ?g. }
- W2144109968 abstract "Acceptance of the fetal semi-allograft by the mother’s immune system has become the focus of intensive research. CD4+ T cells are important actors in the establishment of pregnancy. Th1/Th2 paradigm has been expanded to include CD4+ regulatory T (Treg) and Th17 cells. Pregnancy hormones exert very significant modulatory properties on the maternal immune system. In this review, we describe mechanisms by which the endocrine milieu modulates CD4 T-cell polarisation during pregnancy. We first focused on Treg and Th17 cells and on their importance for pregnancy. Secondly, we review the effects of pregnancy hormones (progesterone, estradiol) on immune cells previously described, with a particular attention to human chorionic gonadotropin (hCG). The importance of Treg cells for pregnancy is evidenced. They are recruited before implantation and are essential for pregnancy maintenance. Decreased number or less efficient Treg cells are implicated in fertility disorders. As for Th17 cells, the few available studies suggest that they have a negative impact on fertility. Th17 frequency is increased in infertile patients. With the combination of its pro-effects on Th2 and Treg cells and anti-effects on Th1 and Th17 cells, P4 contributes to establishment of a favorable environment for pregnancy. E2 effects are more dependent on the context but it seems that E2 promotes Treg and Th2 cells while it inhibits Th1 cells. hCG positively influences activities of Treg and uNK cells. This embryo signal is an essential actor for the success of pregnancy, both as the endocrine factor regulating P4 secretion by the ovarian corpus luteum, but also as a paracrine agent during implantation as well as an angiogenic and immunologic mediator during the course of gestation. LH immune properties begin to be studied but its positive impact on Treg cells suggests that LH could be a considerable immunomodulator in the mouse." @default.
- W2144109968 created "2016-06-24" @default.
- W2144109968 creator A5004251516 @default.
- W2144109968 creator A5008019167 @default.
- W2144109968 creator A5012659211 @default.
- W2144109968 creator A5060565225 @default.
- W2144109968 creator A5062755282 @default.
- W2144109968 creator A5077566468 @default.
- W2144109968 date "2014-07-07" @default.
- W2144109968 modified "2023-10-16" @default.
- W2144109968 title "The Endocrine Milieu and CD4 T-Lymphocyte Polarization during Pregnancy" @default.
- W2144109968 cites W1498159349 @default.
- W2144109968 cites W1509635284 @default.
- W2144109968 cites W1509926487 @default.
- W2144109968 cites W1516386879 @default.
- W2144109968 cites W1530426939 @default.
- W2144109968 cites W1601401351 @default.
- W2144109968 cites W1626837556 @default.
- W2144109968 cites W1635103958 @default.
- W2144109968 cites W1695756438 @default.
- W2144109968 cites W1723695929 @default.
- W2144109968 cites W1806303658 @default.
- W2144109968 cites W1831694374 @default.
- W2144109968 cites W1835714742 @default.
- W2144109968 cites W1847593726 @default.
- W2144109968 cites W1865824513 @default.
- W2144109968 cites W187440043 @default.
- W2144109968 cites W1903362351 @default.
- W2144109968 cites W1951353479 @default.
- W2144109968 cites W1968194779 @default.
- W2144109968 cites W1970608951 @default.
- W2144109968 cites W1971419306 @default.
- W2144109968 cites W1972447650 @default.
- W2144109968 cites W1978451085 @default.
- W2144109968 cites W1983895762 @default.
- W2144109968 cites W1984340410 @default.
- W2144109968 cites W1984786079 @default.
- W2144109968 cites W1985367250 @default.
- W2144109968 cites W1987424268 @default.
- W2144109968 cites W1987628377 @default.
- W2144109968 cites W1987823475 @default.
- W2144109968 cites W1988142062 @default.
- W2144109968 cites W1988911128 @default.
- W2144109968 cites W1989615266 @default.
- W2144109968 cites W1990103239 @default.
- W2144109968 cites W1990877903 @default.
- W2144109968 cites W1993178390 @default.
- W2144109968 cites W1993986867 @default.
- W2144109968 cites W1994291723 @default.
- W2144109968 cites W1994864933 @default.
- W2144109968 cites W1995331340 @default.
- W2144109968 cites W1996063613 @default.
- W2144109968 cites W2000411341 @default.
- W2144109968 cites W2002726823 @default.
- W2144109968 cites W2005992769 @default.
- W2144109968 cites W2010737442 @default.
- W2144109968 cites W2011621536 @default.
- W2144109968 cites W2014185316 @default.
- W2144109968 cites W2016827757 @default.
- W2144109968 cites W2017057381 @default.
- W2144109968 cites W2018020394 @default.
- W2144109968 cites W2019652859 @default.
- W2144109968 cites W2020624501 @default.
- W2144109968 cites W2024490058 @default.
- W2144109968 cites W2026009551 @default.
- W2144109968 cites W2026445106 @default.
- W2144109968 cites W2027473150 @default.
- W2144109968 cites W2028216049 @default.
- W2144109968 cites W2028424141 @default.
- W2144109968 cites W2033675476 @default.
- W2144109968 cites W2034315313 @default.
- W2144109968 cites W2040538270 @default.
- W2144109968 cites W2041001602 @default.
- W2144109968 cites W2041862485 @default.
- W2144109968 cites W2044767152 @default.
- W2144109968 cites W2045253905 @default.
- W2144109968 cites W2048404240 @default.
- W2144109968 cites W2052264506 @default.
- W2144109968 cites W2055603718 @default.
- W2144109968 cites W2055776081 @default.
- W2144109968 cites W2061234318 @default.
- W2144109968 cites W2070793464 @default.
- W2144109968 cites W2072509185 @default.
- W2144109968 cites W2072853625 @default.
- W2144109968 cites W2074520223 @default.
- W2144109968 cites W2074788705 @default.
- W2144109968 cites W2078753269 @default.
- W2144109968 cites W2081243825 @default.
- W2144109968 cites W2086249405 @default.
- W2144109968 cites W2088783992 @default.
- W2144109968 cites W2092134310 @default.
- W2144109968 cites W2092330799 @default.
- W2144109968 cites W2092669390 @default.
- W2144109968 cites W2092730252 @default.
- W2144109968 cites W2093060517 @default.
- W2144109968 cites W2093165931 @default.
- W2144109968 cites W2098033565 @default.
- W2144109968 cites W2098214350 @default.
- W2144109968 cites W2099703022 @default.
- W2144109968 cites W2102477325 @default.