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- W2144132068 abstract "Over the past decade, the baker’s yeast Saccharomyces cerevisiae has proven to be a useful model system to investigate fundamental questions concerning the pathogenic role of human proteins in neurodegenerative diseases such as Parkinson’s disease (PD). These so-called humanized yeast models for PD initially focused on α -synuclein, which plays a key role in the etiology of PD. Upon expression of this human protein in the baker’s yeast Saccharomyces cerevisiae , the events leading to aggregation and the molecular mechanisms that result in cellular toxicity are faithfully reproduced. More recently, a similar model to study the presumed pathobiology of the α -synuclein interaction partner synphilin-1 has been established. In this review we will discuss recent advances using these humanized yeast models, pointing to new roles for cell wall integrity signaling, Ca 2+ homeostasis, mitophagy, and the cytoskeleton." @default.
- W2144132068 created "2016-06-24" @default.
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- W2144132068 date "2013-01-01" @default.
- W2144132068 modified "2023-10-18" @default.
- W2144132068 title "The Benefits of Humanized Yeast Models to Study Parkinson’s Disease" @default.
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- W2144132068 doi "https://doi.org/10.1155/2013/760629" @default.
- W2144132068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3713309" @default.
- W2144132068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23936613" @default.
- W2144132068 hasPublicationYear "2013" @default.
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