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- W2144142784 abstract "Abstract Free radicals, including oxygen radicals, have been suggested to be participants in the cellular damage caused by cerebral ischemia and post-ischemic reperfusion. To determine the role of the intrinsic antioxidant systems and lipid peroxidation in cerebral ischemic damage, changes in the level of endogenous coenzyme Q homologs, α-tocopherol, glutathione and lipid peroxides in the brain were measured. Male Wistar rats 15–20 weeks of age (420–560 g body weight) had cerebral ischemia induced by injection of a single embolus into the left internal carotid artery (ICA) through the external carotid artery under halothane anesthesia. The animals with an embolus only involving the terminal portion od the ICA were used in this study. Levels of reduced coenzyme Q 9 and Q 10 markedly decreased in the cerebral cortex and hippocampus during ischemia, without any significant change in levels of the oxidized homologs. The levels α-tocopherol also decreased, especially in the hippocampus. Reduced glutathione (GSH) levels decreased markedly, without alteration in the level of oxidized glutathione (GSSG). The level of lipid peroxides measured as thiobarbituric-acid-reactive subtances (TBARS) increased markedly 1 h after ischemia in the hippocampus on both sides. These results that lipid peroxidation due to free radical reactions in initiated during an early stage of ischemia, and intrinsic antioxidants may play a role in protective mechanisms following cerebral ischemia." @default.
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- W2144142784 date "1994-07-01" @default.
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- W2144142784 title "Changes in antioxidants and lipid peroxides during ischemia in the rat brain" @default.
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- W2144142784 doi "https://doi.org/10.1016/0928-4680(94)90024-8" @default.
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