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- W2144183937 abstract "7,12-Dimethylbenz(α)anthracene (DMBA) is a carcinogen capable of inducing various types of tumors.We investigated the effect of DMBA on micro-RNA expression in CBA/CA H2(k) inbred mice after 24 hours and one week from exposure.Expression levels of miR-21, miR-146a and let-7a were significantly higher in the vital organs of the mice 24 hours after DMBA exposure compared to those of the controls. On the other hand, a significant down-regulation of the miRNAs was observed seven days after DMBA administration.Based on our data, DMBA has an impact on the expression of miR-21, let-7a and miR-146a genes. The altered micro-RNA expression can be regarded as an early effect of exposure to chemical carcinogens. To our knowledge, this is the first study of miRNA modulation caused by DMBA in non-malignant tissues." @default.
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- W2144183937 date "2012-01-03" @default.
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- W2144183937 title "DMBA induces deregulation of miRNA expression of let-7, miR-21 and miR-146a in CBA/CA mice." @default.
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