FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144196452> ?p ?o ?g. }

• W2144196452 endingPage "673" @default.
• W2144196452 startingPage "666" @default.
• W2144196452 abstract "Lung cancer is the leading cause of cancer death in both men and women in the United States, with a low 5-year survival rate despite improved treatment strategies. These data underscore the great need for effective chemoprevention of this cancer. Mutations and activation of KRAS occur frequently in, and are thought to be a primary driver of the development of, non–small cell lung cancers (NSCLC) of the adenocarcinoma subtype. In this study, we developed a new approach for the chemoprevention of NSCLC involving specific targeting of apoptosis in mutant KRAS cells. This approach is based on a synthetic lethal interaction among TNF-related apoptosis-inducing ligand (TRAIL), the second mitochondria-derived activator of caspase Smac/DIABLO (Smac), and KRAS. Mutational activation of KRAS modulated the expression of TRAIL receptors by upregulating death receptors and downregulating decoy receptors. Furthermore, oncogenic KRAS repressed cellular FADD-like interleukin 1β–converting enzyme (FLICE)-like inhibitory protein (c-FLIP) expression through activation of Erk/mitogen-activated protein kinase (MAPK)-mediated activation of c-Myc. Smac overcame KRAS-induced cell-survival signaling by antagonizing X-linked inhibitor of apoptosis protein (XIAP). Therefore, the combination of TRAIL and a small molecule mimic of Smac induced apoptosis specifically in mutant KRAS cells without harming normal cells. We further showed that short-term, intermittent in vivo treatment with TRAIL and Smac mimic induced apoptosis in tumor cells and reduced tumor burden in a murine model of KRAS-induced lung cancer. These results reflect the potential benefit of a selective therapeutic approach for the chemoprevention of NSCLC. Cancer Prev Res; 4(5); 666–73. ©2011 AACR." @default.
• W2144196452 created "2016-06-24" @default.
• W2144196452 creator A5000349318 @default.
• W2144196452 creator A5019096810 @default.
• W2144196452 creator A5042731770 @default.
• W2144196452 creator A5070248614 @default.
• W2144196452 creator A5077741672 @default.
• W2144196452 date "2011-05-01" @default.
• W2144196452 modified "2023-10-16" @default.
• W2144196452 title "Lung-Cancer Chemoprevention by Induction of Synthetic Lethality in Mutant KRAS Premalignant Cells In Vitro and In Vivo" @default.
• W2144196452 cites W1829810608 @default.
• W2144196452 cites W1910698471 @default.
• W2144196452 cites W1979241548 @default.
• W2144196452 cites W1992742879 @default.
• W2144196452 cites W1994772304 @default.
• W2144196452 cites W1996981979 @default.
• W2144196452 cites W1998982181 @default.
• W2144196452 cites W1999441881 @default.
• W2144196452 cites W2009235369 @default.
• W2144196452 cites W2016979416 @default.
• W2144196452 cites W2017289276 @default.
• W2144196452 cites W2032019019 @default.
• W2144196452 cites W2034071655 @default.
• W2144196452 cites W2042409437 @default.
• W2144196452 cites W2048219592 @default.
• W2144196452 cites W2052609775 @default.
• W2144196452 cites W2056217426 @default.
• W2144196452 cites W2090443758 @default.
• W2144196452 cites W2097186309 @default.
• W2144196452 cites W2097644162 @default.
• W2144196452 cites W2097672870 @default.
• W2144196452 cites W2103031848 @default.
• W2144196452 cites W2106284224 @default.
• W2144196452 cites W2106461550 @default.
• W2144196452 cites W2119326933 @default.
• W2144196452 cites W2123596976 @default.
• W2144196452 cites W2126604711 @default.
• W2144196452 cites W2130988210 @default.
• W2144196452 cites W2134640988 @default.
• W2144196452 cites W2137478129 @default.
• W2144196452 cites W2140481652 @default.
• W2144196452 cites W2158734599 @default.
• W2144196452 cites W2159594827 @default.
• W2144196452 cites W2159999972 @default.
• W2144196452 cites W2163809120 @default.
• W2144196452 cites W2169522961 @default.
• W2144196452 cites W2279299471 @default.
• W2144196452 cites W2566863750 @default.
• W2144196452 cites W34205200 @default.
• W2144196452 doi "https://doi.org/10.1158/1940-6207.capr-10-0235" @default.
• W2144196452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21543344" @default.
• W2144196452 hasPublicationYear "2011" @default.
• W2144196452 type Work @default.
• W2144196452 sameAs 2144196452 @default.
• W2144196452 citedByCount "22" @default.
• W2144196452 countsByYear W21441964522012 @default.
• W2144196452 countsByYear W21441964522013 @default.
• W2144196452 countsByYear W21441964522014 @default.
• W2144196452 countsByYear W21441964522015 @default.
• W2144196452 countsByYear W21441964522016 @default.
• W2144196452 countsByYear W21441964522017 @default.
• W2144196452 countsByYear W21441964522018 @default.
• W2144196452 countsByYear W21441964522019 @default.
• W2144196452 countsByYear W21441964522020 @default.
• W2144196452 countsByYear W21441964522022 @default.
• W2144196452 crossrefType "journal-article" @default.
• W2144196452 hasAuthorship W2144196452A5000349318 @default.
• W2144196452 hasAuthorship W2144196452A5019096810 @default.
• W2144196452 hasAuthorship W2144196452A5042731770 @default.
• W2144196452 hasAuthorship W2144196452A5070248614 @default.
• W2144196452 hasAuthorship W2144196452A5077741672 @default.
• W2144196452 hasBestOaLocation W21441964521 @default.
• W2144196452 hasConcept C104317684 @default.
• W2144196452 hasConcept C121608353 @default.
• W2144196452 hasConcept C126322002 @default.
• W2144196452 hasConcept C143065580 @default.
• W2144196452 hasConcept C184235292 @default.
• W2144196452 hasConcept C190283241 @default.
• W2144196452 hasConcept C2776055636 @default.
• W2144196452 hasConcept C2776256026 @default.
• W2144196452 hasConcept C2777408456 @default.
• W2144196452 hasConcept C2778502085 @default.
• W2144196452 hasConcept C2781187634 @default.
• W2144196452 hasConcept C31573885 @default.
• W2144196452 hasConcept C33195913 @default.
• W2144196452 hasConcept C502942594 @default.
• W2144196452 hasConcept C526805850 @default.
• W2144196452 hasConcept C55493867 @default.
• W2144196452 hasConcept C57074206 @default.
• W2144196452 hasConcept C71924100 @default.
• W2144196452 hasConcept C86803240 @default.
• W2144196452 hasConcept C95444343 @default.
• W2144196452 hasConcept C96232424 @default.
• W2144196452 hasConcept C98424977 @default.
• W2144196452 hasConceptScore W2144196452C104317684 @default.
• W2144196452 hasConceptScore W2144196452C121608353 @default.
• W2144196452 hasConceptScore W2144196452C126322002 @default.
• W2144196452 hasConceptScore W2144196452C143065580 @default.

• next