Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144203496> ?p ?o ?g. }
- W2144203496 endingPage "1197" @default.
- W2144203496 startingPage "1185" @default.
- W2144203496 abstract "The goal of this study was to identify candidate genes and DNA polymorphisms for quantitative trait loci (QTL) affecting milk yield (MY), fat yield (FY), and protein yield (PY) previously mapped to bovine chromosome 3 (BTA3). To accomplish this, 373 half-siblings sired by three bulls previously shown to be segregating for lactation trait QTL, and 263 additional sires in the U.S. Dairy Bull DNA Repository (DBDR) were genotyped for 2,500 SNPs within a 16.3 Mbp QTL critical region on BTA3. Targeted resequencing of ∼1.8 Mbp within the QTL critical region of one of the QTL heterozygous sires identified additional polymorphisms useful for association studies. Twenty-three single nucleotide polymorphisms (SNPs) within a fine-mapped region were associated with effects on breeding values for MY, FY, or PY in DBDR sires, of which five SNPs were in strong linkage disequilibrium in the population. This multisite haplotype included SNPs located within exons or promoters of four tightly linked genes: RAP1A, ADORA3, OVGP1, and C3H1orf88. An SNP within RAP1A showed strong evidence of a recent selective sweep based on integrated haplotype score and was also associated with breeding value for PY. Because of its known function in alveolar lumen formation in the mammary gland, RAP1A is thus a strong candidate gene for QTL effects on lactation traits. Our results provide a detailed assessment of a QTL region that will be a useful guide for complex traits analysis in humans and other noninbred species." @default.
- W2144203496 created "2016-06-24" @default.
- W2144203496 creator A5004761828 @default.
- W2144203496 creator A5005228412 @default.
- W2144203496 creator A5007998668 @default.
- W2144203496 creator A5010054033 @default.
- W2144203496 creator A5013387907 @default.
- W2144203496 creator A5046028441 @default.
- W2144203496 creator A5048379692 @default.
- W2144203496 creator A5074812838 @default.
- W2144203496 date "2011-11-01" @default.
- W2144203496 modified "2023-10-18" @default.
- W2144203496 title "Multisite haplotype on cattle chromosome 3 is associated with quantitative trait locus effects on lactation traits" @default.
- W2144203496 cites W1511551319 @default.
- W2144203496 cites W1551401951 @default.
- W2144203496 cites W1838763289 @default.
- W2144203496 cites W1964198720 @default.
- W2144203496 cites W1969596239 @default.
- W2144203496 cites W1984943303 @default.
- W2144203496 cites W1987620105 @default.
- W2144203496 cites W2008352137 @default.
- W2144203496 cites W2009080196 @default.
- W2144203496 cites W2011079446 @default.
- W2144203496 cites W2012896828 @default.
- W2144203496 cites W2013167069 @default.
- W2144203496 cites W2015862061 @default.
- W2144203496 cites W2025253353 @default.
- W2144203496 cites W2026728933 @default.
- W2144203496 cites W2028153286 @default.
- W2144203496 cites W2034055696 @default.
- W2144203496 cites W2034264501 @default.
- W2144203496 cites W2039785774 @default.
- W2144203496 cites W2045052763 @default.
- W2144203496 cites W2056048608 @default.
- W2144203496 cites W2056586691 @default.
- W2144203496 cites W2056739929 @default.
- W2144203496 cites W2060432285 @default.
- W2144203496 cites W2070140741 @default.
- W2144203496 cites W2075292410 @default.
- W2144203496 cites W2075571704 @default.
- W2144203496 cites W2077763475 @default.
- W2144203496 cites W2083738752 @default.
- W2144203496 cites W2084184770 @default.
- W2144203496 cites W2088977533 @default.
- W2144203496 cites W2091498804 @default.
- W2144203496 cites W2093186933 @default.
- W2144203496 cites W2096393244 @default.
- W2144203496 cites W2097699209 @default.
- W2144203496 cites W2098381128 @default.
- W2144203496 cites W2098817509 @default.
- W2144203496 cites W2099232387 @default.
- W2144203496 cites W2099568121 @default.
- W2144203496 cites W2108908271 @default.
- W2144203496 cites W2110870557 @default.
- W2144203496 cites W2111381034 @default.
- W2144203496 cites W2114611642 @default.
- W2144203496 cites W2115837368 @default.
- W2144203496 cites W2117424933 @default.
- W2144203496 cites W2118094114 @default.
- W2144203496 cites W2121681870 @default.
- W2144203496 cites W2125105410 @default.
- W2144203496 cites W2128114769 @default.
- W2144203496 cites W2135732313 @default.
- W2144203496 cites W2143645153 @default.
- W2144203496 cites W2152664025 @default.
- W2144203496 cites W2154380613 @default.
- W2144203496 cites W2155496693 @default.
- W2144203496 cites W2156341632 @default.
- W2144203496 cites W2156431476 @default.
- W2144203496 cites W2157211770 @default.
- W2144203496 cites W2160311988 @default.
- W2144203496 cites W2161641617 @default.
- W2144203496 cites W2162530578 @default.
- W2144203496 cites W2163285329 @default.
- W2144203496 cites W2163637837 @default.
- W2144203496 cites W2164559559 @default.
- W2144203496 cites W2168059506 @default.
- W2144203496 cites W2217809488 @default.
- W2144203496 doi "https://doi.org/10.1152/physiolgenomics.00253.2010" @default.
- W2144203496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21896633" @default.
- W2144203496 hasPublicationYear "2011" @default.
- W2144203496 type Work @default.
- W2144203496 sameAs 2144203496 @default.
- W2144203496 citedByCount "12" @default.
- W2144203496 countsByYear W21442034962012 @default.
- W2144203496 countsByYear W21442034962014 @default.
- W2144203496 countsByYear W21442034962016 @default.
- W2144203496 countsByYear W21442034962017 @default.
- W2144203496 countsByYear W21442034962018 @default.
- W2144203496 countsByYear W21442034962019 @default.
- W2144203496 countsByYear W21442034962022 @default.
- W2144203496 crossrefType "journal-article" @default.
- W2144203496 hasAuthorship W2144203496A5004761828 @default.
- W2144203496 hasAuthorship W2144203496A5005228412 @default.
- W2144203496 hasAuthorship W2144203496A5007998668 @default.
- W2144203496 hasAuthorship W2144203496A5010054033 @default.
- W2144203496 hasAuthorship W2144203496A5013387907 @default.
- W2144203496 hasAuthorship W2144203496A5046028441 @default.