FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144204080> ?p ?o ?g. }

• W2144204080 endingPage "147" @default.
• W2144204080 startingPage "140" @default.
• W2144204080 abstract "The quantitative risk assessment (QRA) paradigm has been extended to evaluating the risk of induction of allergic contact dermatitis from consumer products. Sensitization QRA compares product-related, topical exposures to a safe benchmark, the sensitization reference dose. The latter is based on an experimentally or clinically determined 'no observable adverse effect level' (NOAEL) and further refined by incorporating 'sensitization uncertainty factors' (SUFs) that address variables not adequately reflected in the data from which the threshold NOAEL was derived. A critical area of uncertainty for the risk assessment of oral care or feminine hygiene products is the extrapolation from skin to mucosal exposures. Most sensitization data are derived from skin contact, but the permeability of vulvovaginal and oral mucosae is greater than that of keratinized skin. Consequently, the QRA for some personal products that are exposed to mucosal tissue may require the use of more conservative SUFs. This article reviews the scientific basis for SUFs applied to topical exposure to vulvovaginal and oral mucosae. We propose a 20-fold range in the default uncertainty factor used in the contact sensitization QRA when extrapolating from data derived from the skin to situations involving exposure to non-keratinized mucosal tissue." @default.
• W2144204080 created "2016-06-24" @default.
• W2144204080 creator A5010549809 @default.
• W2144204080 creator A5052836370 @default.
• W2144204080 creator A5057935705 @default.
• W2144204080 creator A5080102149 @default.
• W2144204080 creator A5087762671 @default.
• W2144204080 date "2003-09-01" @default.
• W2144204080 modified "2023-10-18" @default.
• W2144204080 title "Quantitative risk assessment for the induction of allergic contact dermatitis: uncertainty factors for mucosal exposures" @default.
• W2144204080 cites W1544311753 @default.
• W2144204080 cites W1561210178 @default.
• W2144204080 cites W1601145807 @default.
• W2144204080 cites W1963735314 @default.
• W2144204080 cites W1963763517 @default.
• W2144204080 cites W1965845975 @default.
• W2144204080 cites W1966324649 @default.
• W2144204080 cites W1971806606 @default.
• W2144204080 cites W1988996430 @default.
• W2144204080 cites W199876327 @default.
• W2144204080 cites W2001213681 @default.
• W2144204080 cites W2008417568 @default.
• W2144204080 cites W2012663457 @default.
• W2144204080 cites W2014751829 @default.
• W2144204080 cites W2026465300 @default.
• W2144204080 cites W2037196798 @default.
• W2144204080 cites W2042927990 @default.
• W2144204080 cites W2057802988 @default.
• W2144204080 cites W2068921992 @default.
• W2144204080 cites W2072887068 @default.
• W2144204080 cites W2073809336 @default.
• W2144204080 cites W2081305691 @default.
• W2144204080 cites W2089728333 @default.
• W2144204080 cites W2090327317 @default.
• W2144204080 cites W2099452046 @default.
• W2144204080 cites W2112844215 @default.
• W2144204080 cites W2116546720 @default.
• W2144204080 cites W2118283772 @default.
• W2144204080 cites W2121944011 @default.
• W2144204080 cites W2129437950 @default.
• W2144204080 cites W2133854477 @default.
• W2144204080 cites W2147728377 @default.
• W2144204080 cites W2167962128 @default.
• W2144204080 cites W2407801680 @default.
• W2144204080 cites W251297179 @default.
• W2144204080 cites W4238338996 @default.
• W2144204080 cites W4251310597 @default.
• W2144204080 doi "https://doi.org/10.1111/j.0105-1873.2003.00192.x" @default.
• W2144204080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14678210" @default.
• W2144204080 hasPublicationYear "2003" @default.
• W2144204080 type Work @default.
• W2144204080 sameAs 2144204080 @default.
• W2144204080 citedByCount "36" @default.
• W2144204080 countsByYear W21442040802012 @default.
• W2144204080 countsByYear W21442040802013 @default.
• W2144204080 countsByYear W21442040802014 @default.
• W2144204080 countsByYear W21442040802016 @default.
• W2144204080 countsByYear W21442040802017 @default.
• W2144204080 countsByYear W21442040802018 @default.
• W2144204080 countsByYear W21442040802019 @default.
• W2144204080 countsByYear W21442040802020 @default.
• W2144204080 countsByYear W21442040802022 @default.
• W2144204080 crossrefType "journal-article" @default.
• W2144204080 hasAuthorship W2144204080A5010549809 @default.
• W2144204080 hasAuthorship W2144204080A5052836370 @default.
• W2144204080 hasAuthorship W2144204080A5057935705 @default.
• W2144204080 hasAuthorship W2144204080A5080102149 @default.
• W2144204080 hasAuthorship W2144204080A5087762671 @default.
• W2144204080 hasConcept C12174686 @default.
• W2144204080 hasConcept C142724271 @default.
• W2144204080 hasConcept C16005928 @default.
• W2144204080 hasConcept C203014093 @default.
• W2144204080 hasConcept C207480886 @default.
• W2144204080 hasConcept C2776056826 @default.
• W2144204080 hasConcept C2776217527 @default.
• W2144204080 hasConcept C2778091633 @default.
• W2144204080 hasConcept C2779717098 @default.
• W2144204080 hasConcept C3018346242 @default.
• W2144204080 hasConcept C38652104 @default.
• W2144204080 hasConcept C41008148 @default.
• W2144204080 hasConcept C71924100 @default.
• W2144204080 hasConceptScore W2144204080C12174686 @default.
• W2144204080 hasConceptScore W2144204080C142724271 @default.
• W2144204080 hasConceptScore W2144204080C16005928 @default.
• W2144204080 hasConceptScore W2144204080C203014093 @default.
• W2144204080 hasConceptScore W2144204080C207480886 @default.
• W2144204080 hasConceptScore W2144204080C2776056826 @default.
• W2144204080 hasConceptScore W2144204080C2776217527 @default.
• W2144204080 hasConceptScore W2144204080C2778091633 @default.
• W2144204080 hasConceptScore W2144204080C2779717098 @default.
• W2144204080 hasConceptScore W2144204080C3018346242 @default.
• W2144204080 hasConceptScore W2144204080C38652104 @default.
• W2144204080 hasConceptScore W2144204080C41008148 @default.
• W2144204080 hasConceptScore W2144204080C71924100 @default.
• W2144204080 hasIssue "3" @default.
• W2144204080 hasLocation W21442040801 @default.
• W2144204080 hasLocation W21442040802 @default.
• W2144204080 hasOpenAccess W2144204080 @default.

• next