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- W2144206844 abstract "Lynch syndrome (LS) is the most common form of inherited predisposition to develop cancer mainly in the colon and endometrium but also in other organ sites. Germline mutations in DNA mismatch repair (MMR) gene cause the transmission of the syndrome in an autosomal dominant manner. The management of LS patients is complicated by the large variation in age at cancer diagnosis which requires these patients to be enrolled in surveillance protocol starting as early as in their second decade of life. Several environmental and genetic factors have been proposed to explain this phenotypic heterogeneity, but the molecular mechanisms remain unknown. Although the presence of genetic anticipation in Lynch syndrome has been suspected since 15 years, only recently the phenomenon has been increasingly reported to be present in different cancer genetic syndromes including LS. While the biological basis of earlier cancer onset in successive generations remains poorly known, recent findings point to telomere dynamics as a mechanism significantly contributing to genetic anticipation in Lynch syndrome and in other familial cancers. In this review, we summarize the clinical and molecular features of Lynch syndrome, with a particular focus on the latest studies that have investigated the molecular mechanisms of genetic anticipation. Keywords: Anticipation, lynch syndrome, MMR genes, microsatellite instability, telomere length, telomere dynamics, cancer, GWAS, mutations, MSH2 genes" @default.
- W2144206844 created "2016-06-24" @default.
- W2144206844 creator A5009733699 @default.
- W2144206844 creator A5045327100 @default.
- W2144206844 creator A5046910307 @default.
- W2144206844 date "2011-11-01" @default.
- W2144206844 modified "2023-10-03" @default.
- W2144206844 title "Anticipation in Lynch Syndrome: Where We Are Where We Go" @default.
- W2144206844 cites W1480547785 @default.
- W2144206844 cites W1513040830 @default.
- W2144206844 cites W1515727599 @default.
- W2144206844 cites W1534626339 @default.
- W2144206844 cites W1538642299 @default.
- W2144206844 cites W1539270425 @default.
- W2144206844 cites W1560231616 @default.
- W2144206844 cites W1562509294 @default.
- W2144206844 cites W1562686203 @default.
- W2144206844 cites W1575406094 @default.
- W2144206844 cites W1606411947 @default.
- W2144206844 cites W1644383846 @default.
- W2144206844 cites W177360280 @default.
- W2144206844 cites W1903736299 @default.
- W2144206844 cites W1930550304 @default.
- W2144206844 cites W1937332065 @default.
- W2144206844 cites W1965004314 @default.
- W2144206844 cites W1970415574 @default.
- W2144206844 cites W1971532948 @default.
- W2144206844 cites W1972254989 @default.
- W2144206844 cites W1973244269 @default.
- W2144206844 cites W1974990650 @default.
- W2144206844 cites W1975476791 @default.
- W2144206844 cites W1976786479 @default.
- W2144206844 cites W1977129262 @default.
- W2144206844 cites W1977688865 @default.
- W2144206844 cites W1978871519 @default.
- W2144206844 cites W1979712953 @default.
- W2144206844 cites W1980598382 @default.
- W2144206844 cites W1981087842 @default.
- W2144206844 cites W1982607444 @default.
- W2144206844 cites W1982824982 @default.
- W2144206844 cites W1983130914 @default.
- W2144206844 cites W1985184859 @default.
- W2144206844 cites W1985641439 @default.
- W2144206844 cites W1988214624 @default.
- W2144206844 cites W1989957148 @default.
- W2144206844 cites W1991106907 @default.
- W2144206844 cites W1991829598 @default.
- W2144206844 cites W1995253398 @default.
- W2144206844 cites W1995575418 @default.
- W2144206844 cites W1998746460 @default.
- W2144206844 cites W2004516373 @default.
- W2144206844 cites W2009052175 @default.
- W2144206844 cites W2020719350 @default.
- W2144206844 cites W2022085708 @default.
- W2144206844 cites W2022257969 @default.
- W2144206844 cites W2022408375 @default.
- W2144206844 cites W2022855722 @default.
- W2144206844 cites W2023598285 @default.
- W2144206844 cites W2023728275 @default.
- W2144206844 cites W2025785990 @default.
- W2144206844 cites W2027495079 @default.
- W2144206844 cites W2027924766 @default.
- W2144206844 cites W2028988391 @default.
- W2144206844 cites W2030307336 @default.
- W2144206844 cites W2030586260 @default.
- W2144206844 cites W2033498327 @default.
- W2144206844 cites W2033632793 @default.
- W2144206844 cites W2034278031 @default.
- W2144206844 cites W2034330444 @default.
- W2144206844 cites W2036649093 @default.
- W2144206844 cites W2038332913 @default.
- W2144206844 cites W2039774169 @default.
- W2144206844 cites W2042111215 @default.
- W2144206844 cites W2045044035 @default.
- W2144206844 cites W2046133602 @default.
- W2144206844 cites W2047041699 @default.
- W2144206844 cites W2049523137 @default.
- W2144206844 cites W2051584526 @default.
- W2144206844 cites W2052584197 @default.
- W2144206844 cites W2055173005 @default.
- W2144206844 cites W2059175595 @default.
- W2144206844 cites W205960099 @default.
- W2144206844 cites W2060559393 @default.
- W2144206844 cites W2060955969 @default.
- W2144206844 cites W2062716963 @default.
- W2144206844 cites W2064483389 @default.
- W2144206844 cites W2065686472 @default.
- W2144206844 cites W2066465360 @default.
- W2144206844 cites W2067110087 @default.
- W2144206844 cites W2068570264 @default.
- W2144206844 cites W2068906373 @default.
- W2144206844 cites W2069904175 @default.
- W2144206844 cites W2074989477 @default.
- W2144206844 cites W2076419355 @default.
- W2144206844 cites W2077907877 @default.
- W2144206844 cites W2080158978 @default.
- W2144206844 cites W2081680846 @default.
- W2144206844 cites W2081902090 @default.