FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144223841> ?p ?o ?g. }

• W2144223841 endingPage "L459" @default.
• W2144223841 startingPage "L449" @default.
• W2144223841 abstract "Despite advancements in renal replacement therapy, the mortality rate for acute kidney injury (AKI) remains unacceptably high, likely due to remote organ injury. Kidney ischemia-reperfusion injury (IRI) activates cellular and soluble mediators that incite a distinct pulmonary proinflammatory and proapoptotic response. Tumor necrosis factor receptor 1 (TNFR1) has been identified as a prominent death receptor activated in the lungs during ischemic AKI. We hypothesized that circulating TNF-α released from the postischemic kidney induces TNFR1-mediated pulmonary apoptosis, and we aimed to elucidate molecular pathways to programmed cell death. Using an established murine model of kidney IRI, we characterized the time course for increased circulatory and pulmonary TNF-α levels and measured concurrent upregulation of pulmonary TNFR1 expression. We then identified TNFR1-dependent pulmonary apoptosis after ischemic AKI using TNFR1-/- mice. Subsequent TNF-α signaling disruption with Etanercept implicated circulatory TNF-α as a key soluble mediator of pulmonary apoptosis and lung microvascular barrier dysfunction during ischemic AKI. We further elucidated pathways of TNFR1-mediated apoptosis with NF-κB (Complex I) and caspase-8 (Complex II) expression and discovered that TNFR1 proapoptotic signaling induces NF-κB activation. Additionally, inhibition of NF-κB (Complex I) resulted in a proapoptotic phenotype, lung barrier leak, and altered cellular flice inhibitory protein signaling independent of caspase-8 (Complex II) activation. Ischemic AKI activates soluble TNF-α and induces TNFR1-dependent pulmonary apoptosis through augmentation of the prosurvival and proapoptotic TNFR1 signaling pathway. Kidney-lung crosstalk after ischemic AKI represents a complex pathological process, yet focusing on specific biological pathways may yield potential future therapeutic targets." @default.
• W2144223841 created "2016-06-24" @default.
• W2144223841 creator A5019012053 @default.
• W2144223841 creator A5019225342 @default.
• W2144223841 creator A5026629319 @default.
• W2144223841 creator A5051771508 @default.
• W2144223841 creator A5074159247 @default.
• W2144223841 date "2012-09-01" @default.
• W2144223841 modified "2023-10-01" @default.
• W2144223841 title "TNFR1-dependent pulmonary apoptosis during ischemic acute kidney injury" @default.
• W2144223841 cites W1538575383 @default.
• W2144223841 cites W1968322275 @default.
• W2144223841 cites W1975417521 @default.
• W2144223841 cites W1983398917 @default.
• W2144223841 cites W1991838261 @default.
• W2144223841 cites W2033169788 @default.
• W2144223841 cites W2033276755 @default.
• W2144223841 cites W2033958453 @default.
• W2144223841 cites W2049653407 @default.
• W2144223841 cites W2051338691 @default.
• W2144223841 cites W2053674702 @default.
• W2144223841 cites W2056426949 @default.
• W2144223841 cites W2059074671 @default.
• W2144223841 cites W2060017302 @default.
• W2144223841 cites W2074801801 @default.
• W2144223841 cites W2083573017 @default.
• W2144223841 cites W2088599644 @default.
• W2144223841 cites W2090112384 @default.
• W2144223841 cites W2090720804 @default.
• W2144223841 cites W2094758488 @default.
• W2144223841 cites W2095346612 @default.
• W2144223841 cites W2101754323 @default.
• W2144223841 cites W2104553354 @default.
• W2144223841 cites W2111935933 @default.
• W2144223841 cites W2135398566 @default.
• W2144223841 cites W2144000554 @default.
• W2144223841 cites W2145173465 @default.
• W2144223841 cites W2148703658 @default.
• W2144223841 cites W2148834609 @default.
• W2144223841 cites W2149687213 @default.
• W2144223841 cites W2158970840 @default.
• W2144223841 cites W2161533677 @default.
• W2144223841 cites W2167799156 @default.
• W2144223841 cites W2189257806 @default.
• W2144223841 cites W2314787815 @default.
• W2144223841 cites W2582602949 @default.
• W2144223841 doi "https://doi.org/10.1152/ajplung.00301.2011" @default.
• W2144223841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3468427" @default.
• W2144223841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22728466" @default.
• W2144223841 hasPublicationYear "2012" @default.
• W2144223841 type Work @default.
• W2144223841 sameAs 2144223841 @default.
• W2144223841 citedByCount "33" @default.
• W2144223841 countsByYear W21442238412012 @default.
• W2144223841 countsByYear W21442238412013 @default.
• W2144223841 countsByYear W21442238412014 @default.
• W2144223841 countsByYear W21442238412015 @default.
• W2144223841 countsByYear W21442238412016 @default.
• W2144223841 countsByYear W21442238412017 @default.
• W2144223841 countsByYear W21442238412018 @default.
• W2144223841 countsByYear W21442238412019 @default.
• W2144223841 countsByYear W21442238412020 @default.
• W2144223841 countsByYear W21442238412021 @default.
• W2144223841 countsByYear W21442238412022 @default.
• W2144223841 countsByYear W21442238412023 @default.
• W2144223841 crossrefType "journal-article" @default.
• W2144223841 hasAuthorship W2144223841A5019012053 @default.
• W2144223841 hasAuthorship W2144223841A5019225342 @default.
• W2144223841 hasAuthorship W2144223841A5026629319 @default.
• W2144223841 hasAuthorship W2144223841A5051771508 @default.
• W2144223841 hasAuthorship W2144223841A5074159247 @default.
• W2144223841 hasBestOaLocation W21442238412 @default.
• W2144223841 hasConcept C104317684 @default.
• W2144223841 hasConcept C126322002 @default.
• W2144223841 hasConcept C127561419 @default.
• W2144223841 hasConcept C164027704 @default.
• W2144223841 hasConcept C17991360 @default.
• W2144223841 hasConcept C190283241 @default.
• W2144223841 hasConcept C203014093 @default.
• W2144223841 hasConcept C2776914184 @default.
• W2144223841 hasConcept C2777714996 @default.
• W2144223841 hasConcept C2779708716 @default.
• W2144223841 hasConcept C2780091579 @default.
• W2144223841 hasConcept C2780472472 @default.
• W2144223841 hasConcept C31573885 @default.
• W2144223841 hasConcept C502942594 @default.
• W2144223841 hasConcept C55493867 @default.
• W2144223841 hasConcept C62478195 @default.
• W2144223841 hasConcept C71924100 @default.
• W2144223841 hasConcept C86803240 @default.
• W2144223841 hasConcept C93880895 @default.
• W2144223841 hasConcept C94030615 @default.
• W2144223841 hasConcept C95444343 @default.
• W2144223841 hasConceptScore W2144223841C104317684 @default.
• W2144223841 hasConceptScore W2144223841C126322002 @default.
• W2144223841 hasConceptScore W2144223841C127561419 @default.
• W2144223841 hasConceptScore W2144223841C164027704 @default.
• W2144223841 hasConceptScore W2144223841C17991360 @default.

• next