FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144226538> ?p ?o ?g. }

• W2144226538 endingPage "759" @default.
• W2144226538 startingPage "745" @default.
• W2144226538 abstract "Embryonic stem (ES) cells have the potential to differentiate into all cell types of the adult body, and could allow regeneration of damaged tissues. The challenge is to alter differentiation toward functional cell types or tissues by directing ES cells to a specific fate. Efforts have been made to understand the molecular mechanisms that are required for the formation of the different germ layers and tissues from ES cells, and these mechanisms appear to be very similar in the mouse embryo. Differentiation toward mesoderm and mesoderm derivatives such as cardiac tissue or hemangioblasts has been demonstrated; however, the roles of Activin A/Nodal, bone morphogenetic protein (BMP), and fibroblast growth factor (FGF) signaling in the early patterning of ES cell-derived pan-mesoderm and anterior visceral endoderm (aVE) have not been reported yet. We therefore analyzed the roles of Activin A/Nodal, BMP, and FGF signaling in the patterning of ES cell-derived mesoderm as well as specification of the aVE by using a dual ES cell differentiation system combining a loss-of-function with a gain-of-function approach. We found that Activin A or Nodal directed the nascent mesoderm toward axial mesoderm and mesendoderm, while Bmp4 was inducing posterior and extraembryonic mesoderm at the expense of anterior primitive streak cells. FGF signaling appeared to have an important role in mesoderm differentiation by allowing an epithelial-to-mesenchymal transition of the newly formed mesoderm cells that would lead to their further patterning. Moreover, inhibition of FGF signaling resulted in increased expression of axial mesoderm markers. Additionally, we revealed that the formation of aVE cells from ES cells requires FGF-dependent Activin A/Nodal signaling and the attenuation of Bmp4 signaling." @default.
• W2144226538 created "2016-06-24" @default.
• W2144226538 creator A5029807963 @default.
• W2144226538 creator A5034467711 @default.
• W2144226538 date "2008-09-01" @default.
• W2144226538 modified "2023-09-23" @default.
• W2144226538 title "Patterning of mouse embryonic stem cell-derived pan-mesoderm by Activin A/Nodal and Bmp4 signaling requires Fibroblast Growth Factor activity" @default.
• W2144226538 cites W1541821200 @default.
• W2144226538 cites W1657005131 @default.
• W2144226538 cites W1720193968 @default.
• W2144226538 cites W1886443720 @default.
• W2144226538 cites W1887141904 @default.
• W2144226538 cites W1922337323 @default.
• W2144226538 cites W1937940610 @default.
• W2144226538 cites W1964691304 @default.
• W2144226538 cites W1965419330 @default.
• W2144226538 cites W1969516758 @default.
• W2144226538 cites W1970147973 @default.
• W2144226538 cites W1977120253 @default.
• W2144226538 cites W1977376400 @default.
• W2144226538 cites W1982748372 @default.
• W2144226538 cites W1985303224 @default.
• W2144226538 cites W1992388470 @default.
• W2144226538 cites W1992865216 @default.
• W2144226538 cites W1992949513 @default.
• W2144226538 cites W1995542274 @default.
• W2144226538 cites W2010856041 @default.
• W2144226538 cites W2025123418 @default.
• W2144226538 cites W2026579311 @default.
• W2144226538 cites W2045899482 @default.
• W2144226538 cites W2046152025 @default.
• W2144226538 cites W2049555359 @default.
• W2144226538 cites W2052128821 @default.
• W2144226538 cites W2053296190 @default.
• W2144226538 cites W2053702504 @default.
• W2144226538 cites W2054361177 @default.
• W2144226538 cites W2058528119 @default.
• W2144226538 cites W2058914749 @default.
• W2144226538 cites W2069022895 @default.
• W2144226538 cites W2069693786 @default.
• W2144226538 cites W2076812266 @default.
• W2144226538 cites W2086943348 @default.
• W2144226538 cites W2092125592 @default.
• W2144226538 cites W2093527972 @default.
• W2144226538 cites W2094145003 @default.
• W2144226538 cites W2103412450 @default.
• W2144226538 cites W2103588034 @default.
• W2144226538 cites W2105361655 @default.
• W2144226538 cites W2107141327 @default.
• W2144226538 cites W2108946209 @default.
• W2144226538 cites W2112856986 @default.
• W2144226538 cites W2113416273 @default.
• W2144226538 cites W2113998165 @default.
• W2144226538 cites W2117456371 @default.
• W2144226538 cites W2118615056 @default.
• W2144226538 cites W2120297737 @default.
• W2144226538 cites W2127417296 @default.
• W2144226538 cites W2131797170 @default.
• W2144226538 cites W2132556256 @default.
• W2144226538 cites W2139020188 @default.
• W2144226538 cites W2147350988 @default.
• W2144226538 cites W2149660935 @default.
• W2144226538 cites W2152274458 @default.
• W2144226538 cites W2162238950 @default.
• W2144226538 cites W2164563970 @default.
• W2144226538 cites W2296436253 @default.
• W2144226538 cites W2411135442 @default.
• W2144226538 doi "https://doi.org/10.1111/j.1432-0436.2007.00257.x" @default.
• W2144226538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18177426" @default.
• W2144226538 hasPublicationYear "2008" @default.
• W2144226538 type Work @default.
• W2144226538 sameAs 2144226538 @default.
• W2144226538 citedByCount "53" @default.
• W2144226538 countsByYear W21442265382012 @default.
• W2144226538 countsByYear W21442265382013 @default.
• W2144226538 countsByYear W21442265382014 @default.
• W2144226538 countsByYear W21442265382015 @default.
• W2144226538 countsByYear W21442265382016 @default.
• W2144226538 countsByYear W21442265382017 @default.
• W2144226538 countsByYear W21442265382018 @default.
• W2144226538 countsByYear W21442265382019 @default.
• W2144226538 countsByYear W21442265382021 @default.
• W2144226538 crossrefType "journal-article" @default.
• W2144226538 hasAuthorship W2144226538A5029807963 @default.
• W2144226538 hasAuthorship W2144226538A5034467711 @default.
• W2144226538 hasConcept C104317684 @default.
• W2144226538 hasConcept C105702510 @default.
• W2144226538 hasConcept C107459253 @default.
• W2144226538 hasConcept C122428330 @default.
• W2144226538 hasConcept C129536746 @default.
• W2144226538 hasConcept C134018914 @default.
• W2144226538 hasConcept C145103041 @default.
• W2144226538 hasConcept C162407555 @default.
• W2144226538 hasConcept C170493617 @default.
• W2144226538 hasConcept C18155467 @default.
• W2144226538 hasConcept C182928434 @default.
• W2144226538 hasConcept C196843134 @default.
• W2144226538 hasConcept C205583638 @default.

• next