Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144227351> ?p ?o ?g. }
- W2144227351 endingPage "e9629" @default.
- W2144227351 startingPage "e9629" @default.
- W2144227351 abstract "Background During untreated, chronic HIV-1 infection, plasma viral load (VL) is a relatively stable quantitative trait that has clinical and epidemiological implications. Immunogenetic research has established various human genetic factors, especially human leukocyte antigen (HLA) variants, as independent determinants of VL set-point. Methodology/Principal Findings To identify and clarify HLA alleles that are associated with either transient or durable immune control of HIV-1 infection, we evaluated the relationships of HLA class I and class II alleles with VL among 563 seroprevalent Zambians (SPs) who were seropositive at enrollment and 221 seroconverters (SCs) who became seropositive during quarterly follow-up visits. After statistical adjustments for non-genetic factors (sex and age), two unfavorable alleles (A*3601 and DRB1*0102) were independently associated with high VL in SPs (p<0.01) but not in SCs. In contrast, favorable HLA variants, mainly A*74, B*13, B*57 (or Cw*18), and one HLA-A and HLA-C combination (A*30+Cw*03), dominated in SCs; their independent associations with low VL were reflected in regression beta estimates that ranged from −0.47±0.23 to −0.92±0.32 log10 in SCs (p<0.05). Except for Cw*18, all favorable variants had diminishing or vanishing association with VL in SPs (p≤0.86). Conclusions/Significance Overall, each of the three HLA class I genes had at least one allele that might contribute to effective immune control, especially during the early course of HIV-1 infection. These observations can provide a useful framework for ongoing analyses of viral mutations induced by protective immune responses." @default.
- W2144227351 created "2016-06-24" @default.
- W2144227351 creator A5013368794 @default.
- W2144227351 creator A5013944378 @default.
- W2144227351 creator A5018681529 @default.
- W2144227351 creator A5022850119 @default.
- W2144227351 creator A5035881745 @default.
- W2144227351 creator A5043775431 @default.
- W2144227351 creator A5053129818 @default.
- W2144227351 creator A5054202053 @default.
- W2144227351 creator A5075524664 @default.
- W2144227351 creator A5077091513 @default.
- W2144227351 date "2010-03-10" @default.
- W2144227351 modified "2023-09-27" @default.
- W2144227351 title "Human Leukocyte Antigens and HIV Type 1 Viral Load in Early and Chronic Infection: Predominance of Evolving Relationships" @default.
- W2144227351 cites W1545913120 @default.
- W2144227351 cites W1963813930 @default.
- W2144227351 cites W1966922291 @default.
- W2144227351 cites W1980607702 @default.
- W2144227351 cites W1981142251 @default.
- W2144227351 cites W1982721121 @default.
- W2144227351 cites W1984727598 @default.
- W2144227351 cites W2001534465 @default.
- W2144227351 cites W2006556166 @default.
- W2144227351 cites W2008633460 @default.
- W2144227351 cites W2012139740 @default.
- W2144227351 cites W2015734929 @default.
- W2144227351 cites W2015751862 @default.
- W2144227351 cites W2021840422 @default.
- W2144227351 cites W2025481552 @default.
- W2144227351 cites W2029124946 @default.
- W2144227351 cites W2031076416 @default.
- W2144227351 cites W2035555649 @default.
- W2144227351 cites W2044833878 @default.
- W2144227351 cites W2045551237 @default.
- W2144227351 cites W2050730390 @default.
- W2144227351 cites W2055350602 @default.
- W2144227351 cites W2057481372 @default.
- W2144227351 cites W2063485002 @default.
- W2144227351 cites W2064882742 @default.
- W2144227351 cites W2065137093 @default.
- W2144227351 cites W2065581751 @default.
- W2144227351 cites W2067695164 @default.
- W2144227351 cites W2069926681 @default.
- W2144227351 cites W2075783643 @default.
- W2144227351 cites W2084050866 @default.
- W2144227351 cites W2087484510 @default.
- W2144227351 cites W2091932385 @default.
- W2144227351 cites W2092434970 @default.
- W2144227351 cites W2094092147 @default.
- W2144227351 cites W2095983332 @default.
- W2144227351 cites W2101030565 @default.
- W2144227351 cites W2103219211 @default.
- W2144227351 cites W2105935286 @default.
- W2144227351 cites W2106442980 @default.
- W2144227351 cites W2107666854 @default.
- W2144227351 cites W2109086160 @default.
- W2144227351 cites W2109530717 @default.
- W2144227351 cites W2116831178 @default.
- W2144227351 cites W2122455852 @default.
- W2144227351 cites W2122718492 @default.
- W2144227351 cites W2123286852 @default.
- W2144227351 cites W2123584222 @default.
- W2144227351 cites W2125377484 @default.
- W2144227351 cites W2129300601 @default.
- W2144227351 cites W2130198866 @default.
- W2144227351 cites W2134182833 @default.
- W2144227351 cites W2145378546 @default.
- W2144227351 cites W2145945613 @default.
- W2144227351 cites W2146366486 @default.
- W2144227351 cites W2147134928 @default.
- W2144227351 cites W2147258683 @default.
- W2144227351 cites W2151326236 @default.
- W2144227351 cites W2151760147 @default.
- W2144227351 cites W2152381343 @default.
- W2144227351 cites W2153778605 @default.
- W2144227351 cites W2156383712 @default.
- W2144227351 cites W2159859837 @default.
- W2144227351 cites W2160538807 @default.
- W2144227351 cites W2161506007 @default.
- W2144227351 cites W2162322548 @default.
- W2144227351 cites W2164299931 @default.
- W2144227351 cites W2164386560 @default.
- W2144227351 cites W2164861987 @default.
- W2144227351 cites W2165579407 @default.
- W2144227351 cites W2166157833 @default.
- W2144227351 cites W2169616551 @default.
- W2144227351 cites W2169718998 @default.
- W2144227351 cites W2170078635 @default.
- W2144227351 cites W2170315872 @default.
- W2144227351 cites W2170430128 @default.
- W2144227351 cites W2171754982 @default.
- W2144227351 cites W2253990994 @default.
- W2144227351 cites W2314461521 @default.
- W2144227351 cites W2321840606 @default.
- W2144227351 cites W28108870 @default.
- W2144227351 cites W4249954132 @default.
- W2144227351 doi "https://doi.org/10.1371/journal.pone.0009629" @default.