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• W2144237795 abstract "Software tools for regional quantification of brain images can be useful adjuncts in interpreting PET scans and quantifying metabolic changes occurring in individuals over time. Automated quantification methods generally rely on initial transformation of scans into template space, but relative contributions of different steps of that process have not been well-defined. 102 brain FDG PET scans were examined _ 36 from 18 Normal subjects (N) and 16 from 8 AD subjects (AD) all recruited for the Alzheimer's disease Neuroimaging Initiative, then studied at baseline and 2 years later, used for assessment of metabolic decline; and 50 from 50 subjects with mild decline in cognition (MDC) used for assessment of baseline hypometabolism associated with early cognitive changes. All scans were quantified after conforming each to a normal template by both of two approaches: an iterative elastic (E, nonlinear) transformation into template space, or a two-step process involving initial rigid (linear) pre-registration of each scan with template prior to application of the E transformation algorithm (RE). Mean activities in 47 standardized volumes of interest (VOIs) were measured in each scan, and normalized to pontine activity. For the 50 scans from MDC subjects, activities of 22 VOIs changed after rigid pre-registration, 3 becoming less hypometabolic and 19 more profoundly hypometabolic, with 14/19 VOIs occurring in Alzheimer-related regions. Both E and RE methods found 9 VOIs demonstrating metabolic decline with a significance level by paired t-test of t > 2.0 in AD; in N, only 1 (by E) or 2 (by RE) such VOIs occurred. With RE of AD, all 9 VOIs were in the temporal lobe. With E, 6 of the 9 VOIs were in the temporal lobe while 2 of the remaining 3 were in medial anterior frontocortical regions, suggesting a greater atrophy-related influence on VOI values when rigid pre-registration is omitted. Moreover, 7 VOIs after RE had t > 3.0 (highest 5.6) whereas only 2 sVOI's after E (highest 3.3) did. Initial rigid pre-registration preceding elastic transformation to template space increased significance of both baseline hypometabolism and longitudinal metabolic decline in regions of the brain implicated in AD-related hypometabolism and its progression." @default.
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• W2144237795 date "2009-07-01" @default.
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• W2144237795 title "P2-008: Contributions of rigid and elastic spatial transformation steps to analysis of Alzheimer-related metabolic changes using automated regional quantification of brain PET scans" @default.
• W2144237795 doi "https://doi.org/10.1016/j.jalz.2009.04.317" @default.
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