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- W2144248840 abstract "The inhibition of Aplysia pleural mechanosensory neuron synapses by dopamine and serotonin through activation of endogenous dopaminergic and expressed 5-HT 1Apl(a)/b receptors, respectively, involves a reduction in action potential-associated calcium influx. We show that the inhibition of synaptic efficacy is downstream of the readily releasable pool, suggesting that inhibition is at the level of calcium secretion coupling, likely a result of the changes in the calcium current. Indeed, the inhibitory responses directly reduce a Ca V 2-like calcium current in isolated sensory neurons. The inhibition of the calcium current is voltage independent as it is not affected by a strong depolarizing prepulse, consistent with other invertebrate Ca V 2 calcium currents. Similar to voltage-independent inhibition of vertebrate nociceptors, inhibition was blocked with Src tyrosine kinase inhibitors. The data suggest a conserved mechanism by which G protein-coupled receptor activation can inhibit the Ca V 2 calcium current in nociceptive neurons." @default.
- W2144248840 created "2016-06-24" @default.
- W2144248840 creator A5043678788 @default.
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- W2144248840 date "2013-11-01" @default.
- W2144248840 modified "2023-09-27" @default.
- W2144248840 title "Inhibition of the <i>Aplysia</i> sensory neuron calcium current with dopamine and serotonin" @default.
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- W2144248840 doi "https://doi.org/10.1152/jn.00217.2013" @default.
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