Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144249688> ?p ?o ?g. }
- W2144249688 endingPage "613" @default.
- W2144249688 startingPage "604" @default.
- W2144249688 abstract "The electrical signals of neurons are fundamentally dependent on voltage-gated sodium channels (VGSCs), which are responsible for the rising phase of the action potential. An array of naturally occurring and synthetic neurotoxins have been identified that modify the gating properties of VGSCs. Using murine neocortical neurons in primary culture, we have compared the ability of VGSC gating modifiers to evoke Na<sup>+</sup> influx. Intracellular sodium concentration ([Na<sup>+</sup>]<sub>i</sub>) was monitored using the Na<sup>+</sup>-sensitive fluorescent dye, sodium-binding benzofuran isophthalate. All sodium channel gating modifier compounds tested produced a rapid and concentration-dependent elevation in neuronal [Na<sup>+</sup>]<sub>i</sub>. The increment in [Na<sup>+</sup>]<sub>i</sub> exceeded 40 mM at high concentrations of brevetoxins, batrachotoxin, and the novel lipopeptide, antillatoxin. The maximal increments in neuronal [Na<sup>+</sup>]<sub>i</sub> produced by neurotoxin site 2 alkaloids, veratridine and aconitine, and the pyrethroid deltamethrin were somewhat lower with maximal [Na<sup>+</sup>]<sub>i</sub> increments of less than 40 mM. The rank order of efficacy of sodium channel gating modifiers was brevetoxin (PbTx)-1 > PbTx-desoxydioxolane > batrachotoxin > antillatoxin > PbTx-2 = PbTx-3 > PbTx-3α-naphthoate > veratridine > deltamethrin > aconitine > gambierol. These data demonstrate that the ability of sodium channel gating modifiers to act as partial agonists is shared by compounds acting at both neurotoxin sites 2 and 5. The concentration-dependent increases in [Na<sup>+</sup>]<sub>i</sub> produced by PbTx-2, antillatoxin, veratridine, deltamethrin, aconitine, and gambierol were all abrogated by tetrodotoxin, indicating that VGSCs represent the sole pathway of Na<sup>+</sup> entry after exposure to gating modifier neurotoxins." @default.
- W2144249688 created "2016-06-24" @default.
- W2144249688 creator A5015879809 @default.
- W2144249688 creator A5017681824 @default.
- W2144249688 creator A5019456473 @default.
- W2144249688 creator A5049838876 @default.
- W2144249688 creator A5078651116 @default.
- W2144249688 creator A5080491714 @default.
- W2144249688 date "2008-04-30" @default.
- W2144249688 modified "2023-10-14" @default.
- W2144249688 title "Influence of Lipid-Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons" @default.
- W2144249688 cites W1516736348 @default.
- W2144249688 cites W1522944183 @default.
- W2144249688 cites W1551565062 @default.
- W2144249688 cites W1575874727 @default.
- W2144249688 cites W1657182769 @default.
- W2144249688 cites W1863291796 @default.
- W2144249688 cites W1975868709 @default.
- W2144249688 cites W1979039803 @default.
- W2144249688 cites W1986546640 @default.
- W2144249688 cites W1989416251 @default.
- W2144249688 cites W1990323937 @default.
- W2144249688 cites W2018106786 @default.
- W2144249688 cites W2019533734 @default.
- W2144249688 cites W2019665288 @default.
- W2144249688 cites W2021456078 @default.
- W2144249688 cites W2028922575 @default.
- W2144249688 cites W2040248531 @default.
- W2144249688 cites W2055145435 @default.
- W2144249688 cites W2056579684 @default.
- W2144249688 cites W2057196350 @default.
- W2144249688 cites W2060146265 @default.
- W2144249688 cites W2061695857 @default.
- W2144249688 cites W2075365473 @default.
- W2144249688 cites W2082330257 @default.
- W2144249688 cites W2087216745 @default.
- W2144249688 cites W2091131803 @default.
- W2144249688 cites W2095629435 @default.
- W2144249688 cites W2113448091 @default.
- W2144249688 cites W2119857062 @default.
- W2144249688 cites W2120996046 @default.
- W2144249688 cites W2123223493 @default.
- W2144249688 cites W2133398472 @default.
- W2144249688 cites W2155012962 @default.
- W2144249688 cites W2158141822 @default.
- W2144249688 cites W2401303430 @default.
- W2144249688 cites W2406543325 @default.
- W2144249688 cites W4235205163 @default.
- W2144249688 doi "https://doi.org/10.1124/jpet.108.138230" @default.
- W2144249688 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2852114" @default.
- W2144249688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18448863" @default.
- W2144249688 hasPublicationYear "2008" @default.
- W2144249688 type Work @default.
- W2144249688 sameAs 2144249688 @default.
- W2144249688 citedByCount "47" @default.
- W2144249688 countsByYear W21442496882012 @default.
- W2144249688 countsByYear W21442496882013 @default.
- W2144249688 countsByYear W21442496882014 @default.
- W2144249688 countsByYear W21442496882015 @default.
- W2144249688 countsByYear W21442496882016 @default.
- W2144249688 countsByYear W21442496882017 @default.
- W2144249688 countsByYear W21442496882018 @default.
- W2144249688 countsByYear W21442496882019 @default.
- W2144249688 countsByYear W21442496882020 @default.
- W2144249688 countsByYear W21442496882021 @default.
- W2144249688 countsByYear W21442496882022 @default.
- W2144249688 countsByYear W21442496882023 @default.
- W2144249688 crossrefType "journal-article" @default.
- W2144249688 hasAuthorship W2144249688A5015879809 @default.
- W2144249688 hasAuthorship W2144249688A5017681824 @default.
- W2144249688 hasAuthorship W2144249688A5019456473 @default.
- W2144249688 hasAuthorship W2144249688A5049838876 @default.
- W2144249688 hasAuthorship W2144249688A5078651116 @default.
- W2144249688 hasAuthorship W2144249688A5080491714 @default.
- W2144249688 hasBestOaLocation W21442496882 @default.
- W2144249688 hasConcept C12554922 @default.
- W2144249688 hasConcept C178790620 @default.
- W2144249688 hasConcept C185592680 @default.
- W2144249688 hasConcept C194544171 @default.
- W2144249688 hasConcept C2776986425 @default.
- W2144249688 hasConcept C2777547430 @default.
- W2144249688 hasConcept C2780358027 @default.
- W2144249688 hasConcept C2780456920 @default.
- W2144249688 hasConcept C43617362 @default.
- W2144249688 hasConcept C50952357 @default.
- W2144249688 hasConcept C537181965 @default.
- W2144249688 hasConcept C55493867 @default.
- W2144249688 hasConcept C71240020 @default.
- W2144249688 hasConcept C86803240 @default.
- W2144249688 hasConceptScore W2144249688C12554922 @default.
- W2144249688 hasConceptScore W2144249688C178790620 @default.
- W2144249688 hasConceptScore W2144249688C185592680 @default.
- W2144249688 hasConceptScore W2144249688C194544171 @default.
- W2144249688 hasConceptScore W2144249688C2776986425 @default.
- W2144249688 hasConceptScore W2144249688C2777547430 @default.
- W2144249688 hasConceptScore W2144249688C2780358027 @default.
- W2144249688 hasConceptScore W2144249688C2780456920 @default.
- W2144249688 hasConceptScore W2144249688C43617362 @default.