Matches in SemOpenAlex for { <https://semopenalex.org/work/W2144251330> ?p ?o ?g. }
- W2144251330 endingPage "1003" @default.
- W2144251330 startingPage "993" @default.
- W2144251330 abstract "Prostate cancer is a major cause of cancer-related death in American men, for which finding new therapeutic strategies remains a challenge. Early growth response-1 (EGR1) is a transcription factor involved in cell proliferation and in the regulation of apoptosis. Although it has long been considered a tumor suppressor, a wealth of new evidence shows that EGR1 promotes the progression of prostate cancer. This review addresses the paradoxes of EGR1 function. While EGR1 mediates apoptosis in response to stress and DNA damage by regulating a tumor suppressor network, it also promotes the proliferation of prostate cancer cells by a mechanism that is not fully understood. Thus, EGR1 might be targeted for prostate cancer therapy either by ectopic expression in combination with radiotherapy or chemotherapy, or by direct inhibition for systemic treatment. Possible strategies to antagonize EGR1 function in a therapeutic setting are discussed." @default.
- W2144251330 created "2016-06-24" @default.
- W2144251330 creator A5064705293 @default.
- W2144251330 creator A5075829506 @default.
- W2144251330 date "2009-09-01" @default.
- W2144251330 modified "2023-10-02" @default.
- W2144251330 title "Is EGR1 a potential target for prostate cancer therapy?" @default.
- W2144251330 cites W1497214669 @default.
- W2144251330 cites W1567559129 @default.
- W2144251330 cites W1567881416 @default.
- W2144251330 cites W1590342933 @default.
- W2144251330 cites W1794612623 @default.
- W2144251330 cites W1803513118 @default.
- W2144251330 cites W1893500266 @default.
- W2144251330 cites W1965734230 @default.
- W2144251330 cites W1966782345 @default.
- W2144251330 cites W1967714756 @default.
- W2144251330 cites W1969526312 @default.
- W2144251330 cites W1970999822 @default.
- W2144251330 cites W1975577875 @default.
- W2144251330 cites W1978819041 @default.
- W2144251330 cites W1979742413 @default.
- W2144251330 cites W1980183006 @default.
- W2144251330 cites W1981432908 @default.
- W2144251330 cites W1983918795 @default.
- W2144251330 cites W1984767179 @default.
- W2144251330 cites W1985038223 @default.
- W2144251330 cites W1987110949 @default.
- W2144251330 cites W1990298241 @default.
- W2144251330 cites W1990340849 @default.
- W2144251330 cites W1991172285 @default.
- W2144251330 cites W1998444913 @default.
- W2144251330 cites W1999202494 @default.
- W2144251330 cites W1999823156 @default.
- W2144251330 cites W2000045473 @default.
- W2144251330 cites W2001230322 @default.
- W2144251330 cites W2003142397 @default.
- W2144251330 cites W2003448771 @default.
- W2144251330 cites W2004955468 @default.
- W2144251330 cites W2010057554 @default.
- W2144251330 cites W2017597379 @default.
- W2144251330 cites W2023037141 @default.
- W2144251330 cites W2024375726 @default.
- W2144251330 cites W2025013855 @default.
- W2144251330 cites W2026295446 @default.
- W2144251330 cites W2039462089 @default.
- W2144251330 cites W2046757915 @default.
- W2144251330 cites W2048456023 @default.
- W2144251330 cites W2049170668 @default.
- W2144251330 cites W2051241476 @default.
- W2144251330 cites W2052537645 @default.
- W2144251330 cites W2053502484 @default.
- W2144251330 cites W2056778760 @default.
- W2144251330 cites W2058417123 @default.
- W2144251330 cites W2060339471 @default.
- W2144251330 cites W2060739426 @default.
- W2144251330 cites W2061494834 @default.
- W2144251330 cites W2066650638 @default.
- W2144251330 cites W2068586472 @default.
- W2144251330 cites W2072329780 @default.
- W2144251330 cites W2075514051 @default.
- W2144251330 cites W2078817650 @default.
- W2144251330 cites W2078985610 @default.
- W2144251330 cites W2081662078 @default.
- W2144251330 cites W2084027237 @default.
- W2144251330 cites W2084266051 @default.
- W2144251330 cites W2087610816 @default.
- W2144251330 cites W2090105093 @default.
- W2144251330 cites W2090585013 @default.
- W2144251330 cites W2091285777 @default.
- W2144251330 cites W2096442710 @default.
- W2144251330 cites W2097495301 @default.
- W2144251330 cites W2101885988 @default.
- W2144251330 cites W2103380615 @default.
- W2144251330 cites W2106274709 @default.
- W2144251330 cites W2111078079 @default.
- W2144251330 cites W2111916686 @default.
- W2144251330 cites W2111986039 @default.
- W2144251330 cites W2115960869 @default.
- W2144251330 cites W2120286360 @default.
- W2144251330 cites W2123995229 @default.
- W2144251330 cites W2125079080 @default.
- W2144251330 cites W2128516441 @default.
- W2144251330 cites W2130009954 @default.
- W2144251330 cites W2135446642 @default.
- W2144251330 cites W2147415210 @default.
- W2144251330 cites W2152049148 @default.
- W2144251330 cites W2155214429 @default.
- W2144251330 cites W2155968662 @default.
- W2144251330 cites W2163188200 @default.
- W2144251330 cites W2166866221 @default.
- W2144251330 cites W2167604659 @default.
- W2144251330 cites W2169972304 @default.
- W2144251330 cites W2224993107 @default.
- W2144251330 cites W2324879266 @default.
- W2144251330 cites W4296391086 @default.
- W2144251330 doi "https://doi.org/10.2217/fon.09.67" @default.
- W2144251330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2776080" @default.